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Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer

  • Authors:
    • Yoshihiro Tanaka
    • Yasutoshi Murayama
    • Tatsuya Matsumoto
    • Hidemasa Kubo
    • Kyoichi Harada
    • Hisataka Matsuo
    • Takeshi Kubota
    • Kazuma Okamoto
    • Eigo Otsuji
  • View Affiliations / Copyright

    Affiliations: Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan
    Copyright: © Tanaka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 82
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    Published online on: August 4, 2020
       https://doi.org/10.3892/ol.2020.11943
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Abstract

5‑Aminolevulinic acid‑mediated photodynamic therapy (ALA‑PDT) is a minimally invasive therapeutic modality used in the management of various cancers, but to a lesser extent for esophageal cancer (EC). The current study investigated the antitumor effects of ALA‑PDT. Human EC cells were treated with ALA, after which ALA‑induced fluorescence was examined under a fluorescence microscope. The cytotoxic effects of ALA‑PDT were assessed using three types of LEDs (blue, green and red) in vitro and in vivo. Subcutaneous tumor model mice was constructed with KYSE150 cells. ALA‑PDT was performed once a week for 4 weeks and tumor weights were measured. A popliteal lymph node (PLN) metastasis murine model was generated using KYSE150 cells. KYSE150 cells were inoculated into the left footpad of nude mice. ALA‑PDT was performed on the footpad once a week for 4 weeks. PLNs were then removed 3 weeks after the last treatment. The lymph nodes were evaluated by hematoxylin and eosin staining. Red fluorescence of protoporphyrin IX (PpIX) was observed in all EC cell lines. ALA‑PDT using LEDs exerted significant antitumor effects in vitro and in vivo. The antitumor effects of ALA‑PDT with blue LED were the strongest, followed by green and red LEDs. The number of metastasized PLNs was significantly smaller in the ALA‑PDT group (0%) than in the control group (37.5%). The present results indicated that ALA‑PDT is effective for EC.
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1 

Tachimori Y, Ozawa S, Numasaki H, Ishihara R, Musubara H, Muro K, Oyama T, Toh Y, Udagawa H9 and Uno T; Registration Committee for Esophageal Cancer of the Japan Esophageal Society, : Comprehensive Registry of Esophageal Cancer in Japan, 2010. Eshophagus. 14:189–214. 2017. View Article : Google Scholar

2 

Cancer Registry and Statistics, . Cancer Information Service, National Cancer Center. Japan: October 12–2018

3 

Dougherty TJ, Kaufman JE, Goldfarb A, Weishaupt KR, Boyle D and Mittleman A: Photoradiation therapy for the treatment of malignant tumors. Cancer Res. 38:2628–2635. 1978.PubMed/NCBI

4 

Hayata Y, Kato H, Konaka C, Ono J and Takizawa N: Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer. Chest. 81:269–277. 1982. View Article : Google Scholar : PubMed/NCBI

5 

Mimura S, Ichii M and Okuda S: Photodynamic Therapy for Early Gastric Cancer Using Excimer Dye Laser. Elsevier Science Publication. (Amsterdam). 272–276. 1992.

6 

Lu YG, Wang YY, Yang YD, Zhang XC, Gao Y, Yang Y, Zhang JB and Li GL: Efficacy of topical ALA-PDT combined with excision in the treatment of skin malignant tumor. Photodiagn Photodyn Ther. 11:122–126. 2014. View Article : Google Scholar

7 

Mlkvy P, Messmann H, Debinski H, Regula J, Conio M, MacRobert A, Spigelman A, Phillips R and Bown SG: Photodynamic therapy for polyps in familial adenomatous polyposis - a pilot study. Eur J Cancer. 31A:1160–1165. 1995.PubMed/NCBI

8 

Kübler A, Haase T, Rheinwald M, Barth T and Mühling J: Treatment of oral leukoplakia by topical application of 5-aminolevulinic acid. Int J Oral Maxillofac Surg. 27:466–469. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Loh CS, Bliss P, Bown SG and Krasner N: Photodynamic therapy for villous adenomas of the colon and rectum. Endoscopy. 26:243–246. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Smolka J, Mateasik A, Cunderlikova B, Sanislo L and Mlkvy P: In vivo fluorescence diagnostics and photodynamic therapy of gastrointestinal superficial polyps with aminolevulinic acid. A clinical and spectroscopic study. Neoplasma. 53:418–423. 2006.PubMed/NCBI

11 

Gomer CJ, Rucker N, Ferrario A and Wong S: Properties and applications of photodynamic therapy. Radiat Res. 120:1–18. 1989. View Article : Google Scholar : PubMed/NCBI

12 

Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, Moan J and Peng Q: Photodynamic therapy. J Natl Cancer Inst. 90:889–905. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Dolmans DE, Fukumura D and Jain RK: Photodynamic therapy for cancer. Nat Rev Cancer. 3:380–387. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Yano T, Muto M, Minashi K, Onozawa M, Nihei K, Ishikura S, Kaneko K and Ohtsu A: Long-term results of salvage photodynamic therapy for patients with local failure after chemoradiotherapy for esophageal squamous cell carcinoma. Endoscopy. 43:657–663. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Tsai JC, Wu CL, Chien HF and Chen CT: Reorganization of cytoskeleton induced by 5-aminolevulinic acid-mediated photodynamic therapy and its correlation with mitochondrial dysfunction. Lasers Surg Med. 36:398–408. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Malik Z and Lugaci H: Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins. Br J Cancer. 56:589–595. 1987. View Article : Google Scholar : PubMed/NCBI

17 

Kennedy JC, Pottier RH and Pross DC: Photodynamic therapy with endogenous protoporphyrin IX: Basic principles and present clinical experience. J Photochem Photobiol B. 6:143–148. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Peng Q, Moan J, Warloe T, Nesland JM and Rimington C: Distribution and photosensitizing efficiency of porphyrins induced by application of exogenous 5-aminolevulinic acid in mice bearing mammary carcinoma. Int J Cancer. 52:433–443. 1992. View Article : Google Scholar : PubMed/NCBI

19 

Almeida RD, Manadas BJ, Carvalho AP and Duarte CB: Intracellular signaling mechanisms in photodynamic therapy. Biochim Biophys Acta. 1704:59–86. 2004.PubMed/NCBI

20 

Wachowska M, Muchowicz A, Firczuk M, Gabrysiak M, Winiarska M, Wańczyk M, Bojarczuk K and Golab J: Aminolevulinic acid (ALA) as a prodrug in photodynamic therapy of cancer. Molecules. 16:4140–4164. 2011. View Article : Google Scholar

21 

Vegter S and Tolley K: A network meta-analysis of the relative efficacy of treatments for actinic keratosis of the face or scalp in Europe. PLoS One. 9:e968292014. View Article : Google Scholar : PubMed/NCBI

22 

Fargnoli MC and Peris K: Photodynamic therapy for basal cell carcinoma. Future Oncol. 11:2991–2996. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Wong TW, Sheu HM, Lee JY and Fletcher RJ: Photodynamic therapy for Bowen's disease (squamous cell carcinoma in situ) of the digit. Dermatol Surg. 27:452–456. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Hatakeyama T, Murayama Y, Komatsu S, Shiozaki A, Kuriu Y, Ikoma H, Nakanishi M, Ichikawa D, Fujiwara H, Okamoto K, et al: Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy using light-emitting diodes in human colon cancer cells. Oncol Rep. 29:911–916. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Hino H, Murayama Y, Nakanishi M, Inoue K, Nakajima M and Otsuji E: 5-Aminolevulinic acid-mediated photodynamic therapy using light-emitting diodes of different wavelengths in a mouse model of peritoneally disseminated gastric cancer. J Surg Res. 185:119–126. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Chen X, Zhao P, Chen F, Li L and Luo R: Effect and mechanism of 5-aminolevulinic acid-mediated photodynamic therapy in esophageal cancer. Lasers Med Sci. 26:69–78. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Wakui M, Yokoyama Y, Wang H, Shigeto T, Futagami M and Mizunuma H: Efficacy of a methyl ester of 5-aminolevulinic acid in photodynamic therapy for ovarian cancers. J Cancer Res Clin Oncol. 136:1143–1150. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Ito T, Shimada Y, Kan T, David S, Cheng Y, Mori Y, Agarwal R, Paun B, Jin Z, Olaru A, et al: Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma. Cancer Res. 68:3214–3224. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Mimura S, Ito Y, Nagayo T, Ichii M, Kato H, Sakai H, Goto K, Noguchi Y, Tanimura H, Nagai Y, et al: Cooperative clinical trial of photodynamic therapy with photofrin II and excimer dye laser for early gastric cancer. Lasers Surg Med. 19:168–172. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Kato H, Furukawa K, Sato M, Okunaka T, Kusunoki Y, Kawahara M, Fukuoka M, Miyazawa T, Yana T, Matsui K, et al: Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer. 42:103–111. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Murayama Y, Harada Y, Imaizumi K, Dai P, Nakano K, Okamoto K, Otsuji E and Takamatsu T: Precise detection of lymph node metastases in mouse rectal cancer by using 5-aminolevulinic acid. Int J Cancer. 125:2256–2263. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Nishimura M, Murayama Y, Harada K, Kamada Y, Morimura R, Ikoma H, Ichikawa D, Fujiwara H, Okamoto K and Otsuji E: Photodynamic diagnosis of hepatocellular carcinoma using 5-aminolevulinic acid. Anticancer Res. 36:4569–4574. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Ishizuka M, Abe F, Sano Y, Takahashi K, Inoue K, Nakajima M, Kohda T, Komatsu N, Ogura S and Tanaka T: Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy. Int Immunopharmacol. 11:358–365. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Qiao L, Mei Z, Yang Z, Li X, Cai H and Liu W: ALA-PDT inhibits proliferation and promotes apoptosis of SCC cells through STAT3 signal pathway. Photodiagn Photodyn Ther. 14:66–73. 2016. View Article : Google Scholar

35 

Peng Q, Warloe T, Berg K, Moan J, Kongshaug M, Giercksky KE and Nesland JM: 5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges. Cancer. 79:2282–2308. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Araki K, Ohno S, Egashira A, Saeki H, Kawaguchi H and Sugimachi K: Pathologic features of superficial esophageal squamous cell carcinoma with lymph node and distal metastasis. Cancer. 94:570–575. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Mizuta H, Nishimori I, Kuratani Y, Higashidani Y, Kohsaki T and Onishi S: Predictive factors for esophageal stenosis after endoscopic submucosal dissection for superficial esophageal cancer. Dis Esophagus. 22:626–631. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Dunn JM, Mackenzie GD, Banks MR, Mosse CA, Haidry R, Green S, Thorpe S, Rodriguez-Justo M, Winstanley A, Novelli MR, et al: A randomised controlled trial of ALA vs. Photofrin photodynamic therapy for high-grade dysplasia arising in Barrett's oesophagus. Lasers Med Sci. 28:707–715. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Tammela T, Saaristo A, Holopainen T, Ylä-Herttuala S, Andersson LC, Virolainen S, Immonen I and Alitalo K: Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis. Sci Transl Med. 3:69ra112011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tanaka Y, Murayama Y, Matsumoto T, Kubo H, Harada K, Matsuo H, Kubota T, Okamoto K and Otsuji E: Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer. Oncol Lett 20: 82, 2020.
APA
Tanaka, Y., Murayama, Y., Matsumoto, T., Kubo, H., Harada, K., Matsuo, H. ... Otsuji, E. (2020). Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer. Oncology Letters, 20, 82. https://doi.org/10.3892/ol.2020.11943
MLA
Tanaka, Y., Murayama, Y., Matsumoto, T., Kubo, H., Harada, K., Matsuo, H., Kubota, T., Okamoto, K., Otsuji, E."Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer". Oncology Letters 20.4 (2020): 82.
Chicago
Tanaka, Y., Murayama, Y., Matsumoto, T., Kubo, H., Harada, K., Matsuo, H., Kubota, T., Okamoto, K., Otsuji, E."Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer". Oncology Letters 20, no. 4 (2020): 82. https://doi.org/10.3892/ol.2020.11943
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka Y, Murayama Y, Matsumoto T, Kubo H, Harada K, Matsuo H, Kubota T, Okamoto K and Otsuji E: Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer. Oncol Lett 20: 82, 2020.
APA
Tanaka, Y., Murayama, Y., Matsumoto, T., Kubo, H., Harada, K., Matsuo, H. ... Otsuji, E. (2020). Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer. Oncology Letters, 20, 82. https://doi.org/10.3892/ol.2020.11943
MLA
Tanaka, Y., Murayama, Y., Matsumoto, T., Kubo, H., Harada, K., Matsuo, H., Kubota, T., Okamoto, K., Otsuji, E."Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer". Oncology Letters 20.4 (2020): 82.
Chicago
Tanaka, Y., Murayama, Y., Matsumoto, T., Kubo, H., Harada, K., Matsuo, H., Kubota, T., Okamoto, K., Otsuji, E."Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer". Oncology Letters 20, no. 4 (2020): 82. https://doi.org/10.3892/ol.2020.11943
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