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Overexpression of microRNA‑130a predicts adverse prognosis of primary gastrointestinal diffuse large B‑cell lymphoma

  • Authors:
    • Leiyuan Chen
    • Yutian Kan
    • Xinyuan Wang
    • Peng Ge
    • Tingting Ding
    • Qiongli Zhai
    • Yafei Wang
    • Yong Yu
    • Xiaofang Wang
    • Zhigang Zhao
    • Hongliang Yang
    • Xianming Liu
    • Lanfang Li
    • Lihua Qiu
    • Huilai Zhang
    • Zhengzi Qian
    • Haifeng Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of Laboratory, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of Pathology, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of Lymphoma, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Clinical Research Center for Cancer, Tianjin 300060, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 93
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    Published online on: August 6, 2020
       https://doi.org/10.3892/ol.2020.11954
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Abstract

Primary gastrointestinal diffuse large B‑cell lymphoma (PGI‑DLBCL) is a highly heterogeneous type of non‑Hodgkin lymphoma. A number of studies have demonstrated that microRNA‑130a (miR‑130a) serves a role in the tumorigenesis and prognosis of numerous human tumors. However, to the best of our knowledge, the prognostic significance of miR‑130a in PGI‑DLBCL remains unknown. The present study explored the association between miR‑130a and the clinical outcomes of PGI‑DLBCL. Relative miR‑130a expression was assessed by reverse transcription‑quantitative PCR. Immunohistochemistry was used to detect expression levels of BCL‑2, c‑MYC, neprilysin, B‑cell lymphoma 6 protein, PWWP domain‑containing DNA repair factor 3A and proliferation marker protein Ki‑67. A receiver operating characteristic curve was constructed to analyze the specificity and sensitivity of microRNA levels in the diagnosis of PGI‑DLBCL. Survival curves were constructed using the Kaplan‑Meier method. In the present study, miR‑130a expression was notably higher in patients with PGI‑DLBCL compared with in the controls (P<0.0001). miR‑130a overexpression was closely associated with a high International Prognostic Index score (3‑5) and drug resistance (P=0.017 and P=0.044, respectively). No significant difference in other clinical features was observed. Patients with increased expression levels of miR‑130a had lower overall survival [hazard ratio (HR), 2.998; 95% CI, 1.347‑6.673; P=0.007] and progression‑free survival (HR, 3.325; 95% CI, 1.488‑7.429; P=0.003) compared with patients who had lower expression levels of miR‑130a. Furthermore, multivariate Cox regression analysis suggested that miR‑130a was a negative prognostic parameter in PGI‑DLBCL. Therefore, upregulation of miR‑130a could become a potential prognostic marker for PGI‑DLBCL. Additionally, further study of these results may have important guiding significance for the prognosis of patients with PGI‑DLBCL in the clinical setting.
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Spandidos Publications style
Chen L, Kan Y, Wang X, Ge P, Ding T, Zhai Q, Wang Y, Yu Y, Wang X, Zhao Z, Zhao Z, et al: Overexpression of microRNA‑130a predicts adverse prognosis of primary gastrointestinal diffuse large B‑cell lymphoma. Oncol Lett 20: 93, 2020.
APA
Chen, L., Kan, Y., Wang, X., Ge, P., Ding, T., Zhai, Q. ... Zhao, H. (2020). Overexpression of microRNA‑130a predicts adverse prognosis of primary gastrointestinal diffuse large B‑cell lymphoma. Oncology Letters, 20, 93. https://doi.org/10.3892/ol.2020.11954
MLA
Chen, L., Kan, Y., Wang, X., Ge, P., Ding, T., Zhai, Q., Wang, Y., Yu, Y., Wang, X., Zhao, Z., Yang, H., Liu, X., Li, L., Qiu, L., Zhang, H., Qian, Z., Zhao, H."Overexpression of microRNA‑130a predicts adverse prognosis of primary gastrointestinal diffuse large B‑cell lymphoma". Oncology Letters 20.4 (2020): 93.
Chicago
Chen, L., Kan, Y., Wang, X., Ge, P., Ding, T., Zhai, Q., Wang, Y., Yu, Y., Wang, X., Zhao, Z., Yang, H., Liu, X., Li, L., Qiu, L., Zhang, H., Qian, Z., Zhao, H."Overexpression of microRNA‑130a predicts adverse prognosis of primary gastrointestinal diffuse large B‑cell lymphoma". Oncology Letters 20, no. 4 (2020): 93. https://doi.org/10.3892/ol.2020.11954
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Spandidos Publications style
Chen L, Kan Y, Wang X, Ge P, Ding T, Zhai Q, Wang Y, Yu Y, Wang X, Zhao Z, Zhao Z, et al: Overexpression of microRNA‑130a predicts adverse prognosis of primary gastrointestinal diffuse large B‑cell lymphoma. Oncol Lett 20: 93, 2020.
APA
Chen, L., Kan, Y., Wang, X., Ge, P., Ding, T., Zhai, Q. ... Zhao, H. (2020). Overexpression of microRNA‑130a predicts adverse prognosis of primary gastrointestinal diffuse large B‑cell lymphoma. Oncology Letters, 20, 93. https://doi.org/10.3892/ol.2020.11954
MLA
Chen, L., Kan, Y., Wang, X., Ge, P., Ding, T., Zhai, Q., Wang, Y., Yu, Y., Wang, X., Zhao, Z., Yang, H., Liu, X., Li, L., Qiu, L., Zhang, H., Qian, Z., Zhao, H."Overexpression of microRNA‑130a predicts adverse prognosis of primary gastrointestinal diffuse large B‑cell lymphoma". Oncology Letters 20.4 (2020): 93.
Chicago
Chen, L., Kan, Y., Wang, X., Ge, P., Ding, T., Zhai, Q., Wang, Y., Yu, Y., Wang, X., Zhao, Z., Yang, H., Liu, X., Li, L., Qiu, L., Zhang, H., Qian, Z., Zhao, H."Overexpression of microRNA‑130a predicts adverse prognosis of primary gastrointestinal diffuse large B‑cell lymphoma". Oncology Letters 20, no. 4 (2020): 93. https://doi.org/10.3892/ol.2020.11954
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