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Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells

  • Authors:
    • Yuanle Deng
    • Qianyu Zhang
    • Yali Li
    • Liqun Wang
    • Shuping Yang
    • Xiaotong Chen
    • Cailin Gan
    • Fang He
    • Tinghong Ye
    • Wenya Yin
  • View Affiliations / Copyright

    Affiliations: Department of Nutrition, Food Safety and Toxicology, West China School of Public Health and Healthy Food Evaluation Research Center, Sichuan University, Chengdu, Sichuan 610064, P.R China, State Key of Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610064, P.R China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 116
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    Published online on: August 12, 2020
       https://doi.org/10.3892/ol.2020.11977
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Abstract

Pectolinarigenin a plant secondary metabolite that has various biological effects, including the inhibition of melanogenesis and tumor growth. Melanoma has a high degree of malignancy, with rapid metastasis and severe drug resistance, explaining the need for new candidate drugs that inhibit tumor growth and metastasis. However, the pharmacological action and mechanism of pectolinarigenin on the growth and metastasis of melanoma remain elusive. Thus, the present study aimed to investigate the role of pectolinarigenin in melanoma cell proliferation, apoptosis, migration and invasion. Apoptotic and metastasis‑associated proteins were analyzed using western blotting. The results demonstrated that pectolinarigenin treatment resulted in growth inhibition and apoptosis induction in melanoma cells, arising from the loss of mitochondrial transmembrane potential, reactive oxygen species and the altered expression of apoptosis‑associated proteins. In addition, wound‑healing and Transwell assays demonstrated the potential of pectolinarigenin to impair the migration and invasion of melanoma cells in accordance with the changes in the expression of the associated proteins. Therefore, the results of the present study suggested that pectolinarigenin may serve a pivotal role in promoting melanoma cell apoptosis and reducing metastasis, and may thus be a promising potential candidate for an anti‑melanoma treatment strategy.
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Copy and paste a formatted citation
Spandidos Publications style
Deng Y, Zhang Q, Li Y, Wang L, Yang S, Chen X, Gan C, He F, Ye T, Yin W, Yin W, et al: Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells. Oncol Lett 20: 116, 2020.
APA
Deng, Y., Zhang, Q., Li, Y., Wang, L., Yang, S., Chen, X. ... Yin, W. (2020). Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells. Oncology Letters, 20, 116. https://doi.org/10.3892/ol.2020.11977
MLA
Deng, Y., Zhang, Q., Li, Y., Wang, L., Yang, S., Chen, X., Gan, C., He, F., Ye, T., Yin, W."Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells". Oncology Letters 20.4 (2020): 116.
Chicago
Deng, Y., Zhang, Q., Li, Y., Wang, L., Yang, S., Chen, X., Gan, C., He, F., Ye, T., Yin, W."Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells". Oncology Letters 20, no. 4 (2020): 116. https://doi.org/10.3892/ol.2020.11977
Copy and paste a formatted citation
x
Spandidos Publications style
Deng Y, Zhang Q, Li Y, Wang L, Yang S, Chen X, Gan C, He F, Ye T, Yin W, Yin W, et al: Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells. Oncol Lett 20: 116, 2020.
APA
Deng, Y., Zhang, Q., Li, Y., Wang, L., Yang, S., Chen, X. ... Yin, W. (2020). Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells. Oncology Letters, 20, 116. https://doi.org/10.3892/ol.2020.11977
MLA
Deng, Y., Zhang, Q., Li, Y., Wang, L., Yang, S., Chen, X., Gan, C., He, F., Ye, T., Yin, W."Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells". Oncology Letters 20.4 (2020): 116.
Chicago
Deng, Y., Zhang, Q., Li, Y., Wang, L., Yang, S., Chen, X., Gan, C., He, F., Ye, T., Yin, W."Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS‑mitochondrial apoptotic pathway in melanoma cells". Oncology Letters 20, no. 4 (2020): 116. https://doi.org/10.3892/ol.2020.11977
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