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Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: A propensity score matched study

  • Authors:
    • Qiyu Chi
    • Zheng Shi
    • Zhibo Zhang
    • Xiang Zhang
    • Li Zhang
    • Shangeng Weng
  • View Affiliations / Copyright

    Affiliations: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China, Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China
    Copyright: © Chi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 118
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    Published online on: August 13, 2020
       https://doi.org/10.3892/ol.2020.11979
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Abstract

The incidence of hepatocellular carcinoma (HCC) with bile duct tumour thrombus (BDTT) is low, and related studies, especially studies on long‑term survival, are uncommon. The present study aimed to evaluate the clinicopathological characteristics, prognostic factors and postoperative long‑term outcomes of BDTT in patients with HCC. The clinicopathological characteristics and postoperative long‑term outcomes of patients with HCC both with and without BDTT were compared before and after propensity score matching (PSM). Prognostic risk factors were assessed by Cox proportional hazards regression analyses after PSM. Tumour stages in the BDTT group were significantly higher than those in the group without BDTT (P=0.001). Overall survival (OS) and recurrence‑free survival (RFS) rates were significantly higher in the group without BDTT than in the BDTT group before PSM (P<0.001 and P=0.003, respectively). However, no significant difference in OS or RFS was found between the two groups after PSM (P=0.249 and P=0.121, respectively). Moreover, the median OS and RFS times of the BDTT patients who underwent tumour thrombectomy and bile duct resection were not significantly different (P=0.891 and P=0.787, respectively). In the multivariate analysis, macrovascular invasion (HR, 3.701; 95% CI, 1.313‑9.10.437; P=0.013) was the only independent predictor of OS. Although the clinicopathological characteristics of the BDTT group suggested more advanced stage disease and poorer oncological outcomes than the group without BDTT, BDTT was not a poor prognostic factor for patients with HCC who underwent liver resection. Curative resection is recommended for patients with HCC and BDTT, even for those with poor liver function, after proper perioperative management in order to achieve good long‑term survival.
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Copy and paste a formatted citation
Spandidos Publications style
Chi Q, Shi Z, Zhang Z, Zhang X, Zhang L and Weng S: Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: A propensity score matched study. Oncol Lett 20: 118, 2020.
APA
Chi, Q., Shi, Z., Zhang, Z., Zhang, X., Zhang, L., & Weng, S. (2020). Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: A propensity score matched study. Oncology Letters, 20, 118. https://doi.org/10.3892/ol.2020.11979
MLA
Chi, Q., Shi, Z., Zhang, Z., Zhang, X., Zhang, L., Weng, S."Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: A propensity score matched study". Oncology Letters 20.4 (2020): 118.
Chicago
Chi, Q., Shi, Z., Zhang, Z., Zhang, X., Zhang, L., Weng, S."Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: A propensity score matched study". Oncology Letters 20, no. 4 (2020): 118. https://doi.org/10.3892/ol.2020.11979
Copy and paste a formatted citation
x
Spandidos Publications style
Chi Q, Shi Z, Zhang Z, Zhang X, Zhang L and Weng S: Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: A propensity score matched study. Oncol Lett 20: 118, 2020.
APA
Chi, Q., Shi, Z., Zhang, Z., Zhang, X., Zhang, L., & Weng, S. (2020). Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: A propensity score matched study. Oncology Letters, 20, 118. https://doi.org/10.3892/ol.2020.11979
MLA
Chi, Q., Shi, Z., Zhang, Z., Zhang, X., Zhang, L., Weng, S."Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: A propensity score matched study". Oncology Letters 20.4 (2020): 118.
Chicago
Chi, Q., Shi, Z., Zhang, Z., Zhang, X., Zhang, L., Weng, S."Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: A propensity score matched study". Oncology Letters 20, no. 4 (2020): 118. https://doi.org/10.3892/ol.2020.11979
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