Open Access

Antitumor effects and molecular mechanisms of action of natural products in ovarian cancer (Review)

  • Authors:
    • Yun-Bo Yan
    • Qing Tian
    • Ji-Fang Zhang
    • Ying Xiang
  • View Affiliations

  • Published online on: August 20, 2020     https://doi.org/10.3892/ol.2020.12001
  • Article Number: 141
  • Copyright : © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Ovarian cancer is a common malignancy and the second leading cause of mortality among females with genital tract cancer. At present, postoperative platinum drugs and paclitaxel‑based chemotherapy is the gold standard treatment for ovarian cancer. However, patients who receive this chemotherapy often develop cumulative toxic effects and are prone to chemotherapy resistance. Therefore, it is necessary to determine more effective treatment options that would be better tolerated by patients. Recent studies have reported the therapeutic effects of numerous natural products in patients with ovarian cancer. Notably, these natural ingredients do not induce adverse effects in healthy cells and tissues, suggesting that natural products may serve as a safe alternative treatment for ovarian cancer. The antitumor effects of natural products are attributed to suppression of cell proliferation and metastasis, stimulation of autophagy, improved chemotherapy sensitivity, and induction of apoptosis. The present review focused on the antitumor effects of several natural products, including curcumin, resveratrol, ginsenosides, (‑)‑epigallocatechin‑3‑gallate and quercetin, which are increasingly being investigated as therapeutic options in ovarian cancer, and discussed the molecular mechanisms involved in cell proliferation, apoptosis, autophagy, metastasis and sensitization.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yan Y, Tian Q, Zhang J and Xiang Y: Antitumor effects and molecular mechanisms of action of natural products in ovarian cancer (Review). Oncol Lett 20: 141, 2020
APA
Yan, Y., Tian, Q., Zhang, J., & Xiang, Y. (2020). Antitumor effects and molecular mechanisms of action of natural products in ovarian cancer (Review). Oncology Letters, 20, 141. https://doi.org/10.3892/ol.2020.12001
MLA
Yan, Y., Tian, Q., Zhang, J., Xiang, Y."Antitumor effects and molecular mechanisms of action of natural products in ovarian cancer (Review)". Oncology Letters 20.5 (2020): 141.
Chicago
Yan, Y., Tian, Q., Zhang, J., Xiang, Y."Antitumor effects and molecular mechanisms of action of natural products in ovarian cancer (Review)". Oncology Letters 20, no. 5 (2020): 141. https://doi.org/10.3892/ol.2020.12001