Clinical experience of 23 cases of adenoid cystic carcinoma of the external auditory canal

Jiang,Xiaojun; Jia,Lifeng; Zhang,Xueyuan; Zhong,Cheng; Tang,Feng; Chen,Xiaoling; Yuan,Wei

doi:10.3892/ol.2020.12005

Clinical experience of 23 cases of adenoid cystic carcinoma of the external auditory canal

Authors:
- Xiaojun Jiang
- Lifeng Jia
- Xueyuan Zhang
- Cheng Zhong
- Feng Tang
- Xiaoling Chen
- Wei Yuan
View Affiliations

Affiliations: Department of Otolaryngology Head and Neck Surgery, Chongqing Renji Hospital, University of Chinese Academy of Sciences (Chongqing Fifth People's Hospital), Chongqing 400062, P.R. China, Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of The Third Military Medical University, Chongqing 400038, P.R. China
Published online on: August 21, 2020 https://doi.org/10.3892/ol.2020.12005
Article Number: 144
Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Adenoid cystic carcinoma (ACC) of the external auditory canal (EAC) is a rare tumor. The present study aimed to describe the clinical features and survival of patients with ACC of the EAC. The present retrospective study included 23 patients (mean age, 51.4±15.4 years; 12 males) diagnosed with ACC of the EAC between January 2010 and September 2017 at The First Affiliated Hospital of The Third Military Medical University (Chongqing, China). The median disease course was 24 months. The presenting features were earache in 16 patients, otorrhea in 7 patients, hearing loss in 5 patients, feeling of aural fullness in 2 patients and EAC mass in 4 patients. Tumor stage was T1 in 13 patients, T2 in 3 patients, T3 in 3 patients and T4 in 4 patients. Among patients with T1 tumors, 5 underwent en bloc external EAC resection; 3 underwent local EAC resection; 1 underwent en bloc EAC resection and superficial parotidectomy; 1 underwent subtotal temporal bone resection for postoperative recurrence; Among patients with T4 tumors, 1 underwent extended temporal bone resection, right parotidectomy, right resection of middle cranial fossa tumors and right resection of temporomandibular joint capsule. 1 underwent subtotal temporal bone resection. Among these 15 patients who underwent surgery, 2 received postoperative radiotherapy, 1 received postoperative chemotherapy, 5 received postoperative chemo‑radiotherapy, and 7 did not receive postoperative chemo‑radiotherapy. The 3‑ and 5‑year cumulative survival rates of the 23 patients were 47.8% and 17.4%, respectively. Survival may have been improved in patients who received postoperative chemo‑radiotherapy and early diagnosis may be the key to improving survival.

View Figures

View References

1	Gu FM, Chi FL, Dai CF, Chen B and Li HW: Surgical outcomes of 43 cases with adenoid cystic carcinoma of the external auditory canal. Am J Otolaryngol. 34:394–398. 2013. View Article : Google Scholar : PubMed/NCBI
2	Conley J and Schuller DE: Malignancies of the ear. Laryngoscope. 86:1147–1163. 1976. View Article : Google Scholar : PubMed/NCBI
3	Moore MG, Deschler DG, McKenna MJ, Varvares MA and Lin DT: Management outcomes following lateral temporal bone resection for ear and temporal bone malignancies. Otolaryngol Head Neck Surg. 137:893–898. 2007. View Article : Google Scholar : PubMed/NCBI
4	Dong F, Gidley PW, Ho T, Luna MA, Ginsberg LE and Sturgis EM: Adenoid cystic carcinoma of the external auditory canal. Laryngoscope. 118:1591–1596. 2008. View Article : Google Scholar : PubMed/NCBI
5	Chang CH, Shu MT, Lee JC, Leu YS, Chen YC and Lee KS: Treatments and outcomes of malignant tumors of external auditory canal. Am J Otolaryngol. 30:44–48. 2009. View Article : Google Scholar : PubMed/NCBI
6	Arriaga M, Curtin H, Takahashi H, Hirsch BE and Kamerer DB: Staging proposal for external auditory meatus carcinoma based on preoperative clinical examination and computed tomography findings. Ann Otol Rhinol Laryngol. 99:714–721. 1990. View Article : Google Scholar : PubMed/NCBI
7	Shih L and Crabtree JA: Carcinoma of the external auditory canal: An update. Laryngoscope. 100:1215–1218. 1990. View Article : Google Scholar : PubMed/NCBI
8	Kuhel WI, Hume CR and Selesnick SH: Cancer of the external auditory canal and temporal bone. Otolaryngol Clin North Am. 29:827–852. 1996. View Article : Google Scholar : PubMed/NCBI
9	Testa JR, Fukuda Y and Kowalski LP: Prognostic factors in carcinoma of the external auditory canal. Arch Otolaryngol Head Neck Surg. 123:720–724. 1997. View Article : Google Scholar : PubMed/NCBI
10	Nyrop M and Grontved A: Cancer of the external auditory canal. Arch Otolaryngol Head Neck Surg. 128:834–837. 2002. View Article : Google Scholar : PubMed/NCBI
11	Liu SC, Kang BH, Nieh S, Chang JL and Wang CH: Adenoid cystic carcinoma of the external auditory canal. J Chin Med Assoc. 75:296–300. 2012. View Article : Google Scholar : PubMed/NCBI
12	Zhang T, Dai C and Wang Z: The misdiagnosis of external auditory canal carcinoma. Eur Arch Otorhinolaryngol. 270:1607–1613. 2013. View Article : Google Scholar : PubMed/NCBI
13	Kwok HC, Morton RP, Chaplin JM, McIvor NP and Sillars HA: Quality of life after parotid and temporal bone surgery for cancer. Laryngoscope. 112:820–833. 2002. View Article : Google Scholar : PubMed/NCBI
14	Wang CC: Radiation therapy in the management of carcinoma of the external auditory canal, middle ear, or mastoid. Radiology. 116:713–715. 1975. View Article : Google Scholar : PubMed/NCBI
15	Pulec JL, Parkhill EM and Devine KD: Adenoid cystic carcinoma (Cylindroma) of the external auditory canal. Trans Am Acad Ophthalmol Otolaryngol. 67:673–694. 1963.PubMed/NCBI
16	Perzin KH, Gullane P and Conley J: Adenoid cystic carcinoma involving the external auditory canal. A clinicopathologic study of 16 cases. Cancer. 50:2873–2883. 1982. View Article : Google Scholar : PubMed/NCBI
17	Choi JY, Choi EC, Lee HK, Yoo JB, Kim SG and Lee WS: Mode of parotid involvement in external auditory canal carcinoma. J Laryngol Otol. 117:951–954. 2003. View Article : Google Scholar : PubMed/NCBI
18	O'Neill PB and Parker RA: Sweat gland tumours (ceruminomata) of external auditory meatus. J Laryngol Otol. 71:824–831. 1957. View Article : Google Scholar : PubMed/NCBI
19	Cankar V and Crowley H: Tumors of Ceruminous Glands: A Clinicopathological Study of 7 Cases. Cancer. 17:67–75. 1964. View Article : Google Scholar : PubMed/NCBI
20	Batsakis JG, Hardy GC and Hishiyama RH: Ceruminous gland tumors. Arch Otolaryngol. 86:66–69. 1967. View Article : Google Scholar : PubMed/NCBI
21	Neldner KH: Ceruminoma. Arch Dermatol. 98:344–348. 1968. View Article : Google Scholar : PubMed/NCBI
22	Ahmed GM and Nath DK: Ceruminous gland tumour (a case report). J Laryngol Otol. 102:346–349. 1988. View Article : Google Scholar : PubMed/NCBI
23	Goldman NC: Adenoid cystic carcinoma of the external auditory canal. Otolaryngol Head Neck Surg. 106:214–215. 1992. View Article : Google Scholar : PubMed/NCBI
24	Mohan H, Handa U, Amanjit, Kotwal SA and Dass A: Adenoid cystic carcinoma of the external auditory canal. A case report with diagnosis by fine needle aspiration. Acta Cytol. 47:792–794. 2003. View Article : Google Scholar : PubMed/NCBI
25	Buda-Nowak A, Swiader M, Puskulluoglu M, Dyduch G, Krupinski M and Krzemieniecki K: Adenoid cystic carcinoma of the external auditory canal with metastases to lymph nodes and lungs-problematic diagnosis and treatment based on a case report. Przegl Lek. 72:383–386. 2015.PubMed/NCBI
26	Nayak SP, Walke VA, Helwatkar SB and Bobhate SK: Adenoid cystic carcinoma of the external auditory canal: Report of two cases. Indian J Pathol Microbiol. 52:540–542. 2009. View Article : Google Scholar : PubMed/NCBI
27	Shi X and Dai C: Current status of clinical diagnosis and treatment of temporal bone malignant tumors. Chinese J Otol. 17:311–316. 2019.(In Chinese).
28	Moody SA, Hirsch BE and Myers EN: Squamous cell carcinoma of the external auditory canal: An evaluation of a staging system. Am J Otol. 21:582–588. 2000.PubMed/NCBI
29	Triantafillidou K, Dimitrakopoulos J, Iordanidis F and Koufogiannis D: Management of adenoid cystic carcinoma of minor salivary glands. J Oral Maxillofac Surg. 64:1114–1120. 2006. View Article : Google Scholar : PubMed/NCBI
30	De Lucia A, Gambardella T, Carra P and Motta G: A case of highly aggressive adenoid cystic carcinoma of the external auditory canal. Acta Otorhinolaryngol Ital. 24:354–356. 2004.PubMed/NCBI
31	Fliss DM, Kraus M and Tovi F: Adenoid cystic carcinoma of the external auditory canal. Ear Nose Throat. 69:635, 638–639, 642, passim. 1990.
32	Garden AS, Weber RS, Morrison WH, Ang KK and Peters LJ: The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation. Int J Radiat Oncol Biol Phys. 32:619–626. 1995. View Article : Google Scholar : PubMed/NCBI
33	Yu YF, Zhang R and Dai CF: The study on the en bloc resection of the external auditory canal to treat external auditory canal carcinoma in the early stage. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 7:313–315. 2009.(In Chinese).
34	Liu MB, Zhou QY, Wu WM, Wang JL, Liu LF and Huang DL: A review of 24 cases of external auditory canal adenoid cystic carcinoma. Chin J Otol. 7:2009.(In Chinese).
35	Moffat DA, Wagstaff SA and Hardy DG: The outcome of radical surgery and postoperative radiotherapy for squamous carcinoma of the temporal bone. Laryngoscope. 115:341–347. 2005. View Article : Google Scholar : PubMed/NCBI
36	Chen AM, Bucci MK, Weinberg V, Garcia J, Quivey JM, Schechter NR, Phillips TL, Fu KK and Eisele DW: Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: Prognostic features of recurrence. Int J Radiat Oncol Biol Phys. 66:152–159. 2006. View Article : Google Scholar : PubMed/NCBI
37	Silverman DA, Carlson TP, Khuntia D, Bergstrom RT, Saxton J and Esclamado RM: Role for postoperative radiation therapy in adenoid cystic carcinoma of the head and neck. Laryngoscope. 114:1194–1199. 2004. View Article : Google Scholar : PubMed/NCBI
38	Cristalli G, Manciocco V, Pichi B, Marucci L, Arcangeli G, Telera S and Spriano G: Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. J Craniofac Surg. 20:816–821. 2009. View Article : Google Scholar : PubMed/NCBI
39	Zhao FF, Wang JL, Wu WM, Huang DL, Dai P, Yang SM, Han WJ and Han DY: Clinical analysis of adenoid cystic carcinoma of external auditory canal. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 44:444–448. 2009.(In Chinese). PubMed/NCBI