Open Access

Nuclear receptor FXR impairs SK‑Hep‑1 cell migration and invasion by inhibiting the Wnt/β‑catenin signaling pathway

  • Authors:
    • Qianqian Li
    • Ningbo Li
    • Yeting Zeng
    • Xinrui Wang
    • Jie Li
    • Hongying Su
    • Meiqin Gao
    • Xiongfei Huang
  • View Affiliations

  • Published online on: August 26, 2020     https://doi.org/10.3892/ol.2020.12022
  • Article Number: 161
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Recently, the nuclear receptor farnesoid X receptor (FXR) has been considered to be a liver tumor suppressor. However, the role of FXR in liver cancer invasion and metastasis remains unclear. The results of the current study demonstrated that FXR suppressed the migratory and invasive capacities of SK‑Hep‑1 cells in vitro and that FXR overexpression inhibited local invasion and lung metastasis of SK‑Hep‑1 xenografts in vivo. Bioinformatics analysis of the gene expression profile of SK‑Hep‑1 cells with different FXR levels indicated that FXR may regulate the Wnt/β‑catenin pathway. Compared with controls, FXR‑overexpressing SK‑Hep‑1 cells exhibited decreased expression of β‑catenin target genes and reduced nuclear translocation of β‑catenin proteins in vitro and in vivo. In conclusion, these results indicated that FXR may suppress SK‑Hep‑1 cell invasion and metastasis by suppressing the Wnt/β‑catenin signaling pathway. The current study provided novel insight into the diagnosis and treatment of liver cancer.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li Q, Li N, Zeng Y, Wang X, Li J, Su H, Gao M and Huang X: Nuclear receptor FXR impairs SK‑Hep‑1 cell migration and invasion by inhibiting the Wnt/β‑catenin signaling pathway. Oncol Lett 20: 161, 2020
APA
Li, Q., Li, N., Zeng, Y., Wang, X., Li, J., Su, H. ... Huang, X. (2020). Nuclear receptor FXR impairs SK‑Hep‑1 cell migration and invasion by inhibiting the Wnt/β‑catenin signaling pathway. Oncology Letters, 20, 161. https://doi.org/10.3892/ol.2020.12022
MLA
Li, Q., Li, N., Zeng, Y., Wang, X., Li, J., Su, H., Gao, M., Huang, X."Nuclear receptor FXR impairs SK‑Hep‑1 cell migration and invasion by inhibiting the Wnt/β‑catenin signaling pathway". Oncology Letters 20.5 (2020): 161.
Chicago
Li, Q., Li, N., Zeng, Y., Wang, X., Li, J., Su, H., Gao, M., Huang, X."Nuclear receptor FXR impairs SK‑Hep‑1 cell migration and invasion by inhibiting the Wnt/β‑catenin signaling pathway". Oncology Letters 20, no. 5 (2020): 161. https://doi.org/10.3892/ol.2020.12022