|
1
|
Torre LA, Trabert B, DeSantis CE, Miller
KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A and Siegel RL:
Ovarian cancer statistics, 2018. CA Cancer J Clin. 68:284–296.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Hackshaw A, Gershenson D and Ledermann J:
Mucinous ovarian carcinoma. N Engl J Med. 381:e32019. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Bray F, Ferlay J, Soerjomataram I, Siegel
RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN
estimates of incidence and mortality worldwide for 36 cancers in
185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Wang L, Wang Q, Xu Y and Han L: Advances
in the treatment of ovarian cancer using PARP inhibitors and the
underlying mechanism of resistance. Curr Drug Targets. 21:167–178.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Hansen JM, Coleman RL and Sood AK:
Targeting the tumour microenvironment in ovarian cancer. Eur J
Cancer. 56:131–143. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Liu J, Ren Y, Hou Y, Zhang C, Wang B, Li
X, Sun R and Liu J: Dihydroartemisinin induces endothelial cell
autophagy through suppression of the Akt/mTOR pathway. J Cancer.
10:6057–6064. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Ravikumar B, Sarkar S, Davies JE, Futter
M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M,
Korolchuk VI, Lichtenberg M, Luo S, et al: Regulation of mammalian
autophagy in physiology and pathophysiology. Physiol Rev.
90:1383–1435. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Melendez A and Neufeld TP: The cell
biology of autophagy in metazoans: A developing story. Development.
135:2347–2360. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Boya P, González-Polo RA, Casares N,
Perfettini JL, Dessen P, Larochette N, Métivier D, Meley D,
Souquere S, Yoshimori T, et al: Inhibition of macroautophagy
triggers apoptosis. Mol Cell Biol. 25:1025–1040. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Yue Z, Jin S, Yang C, Levine AJ and Heintz
N: Beclin 1, an autophagy gene essential for early embryonic
development, is a haploinsufficient tumor suppressor. Proc Natl
Acad Sci USA. 100:15077–15082. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Coppola D, Khalil F, Eschrich SA, Boulware
D, Yeatman T and Wang HG: Down-regulation of Bax-interacting
factor-1 in colorectal adenocarcinoma. Cancer. 113:2665–2670. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Boteon YL, Laing R, Mergental H, Reynolds
GM, Mirza DF, Afford SC and Bhogal RH: Mechanisms of autophagy
activation in endothelial cell and their targeting during
normothermic machine liver perfusion. World J Gastroenterol.
23:8443–8451. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Nussenzweig SC, Verma S and Finkel T: The
role of autophagy in vascular biology. Circ Res. 116:480–488. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Liang C, Feng P, Ku B, Dotan I, Canaani D,
Oh BH and Jung JU: Autophagic and tumour suppressor activity of a
novel Beclin1-binding protein UVRAG. Nat Cell Biol. 8:688–699.
2006. View
Article : Google Scholar : PubMed/NCBI
|
|
15
|
Bishop E and Bradshaw TD: Autophagy
modulation: A prudent approach in cancer treatment? Cancer
Chemother Pharmacol. 82:913–922. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Li YJ, Lei YH, Yao N, Wang CR, Hu N, Ye
WC, Zhang DM and Chen ZS: Autophagy and multidrug resistance in
cancer. Chin J Cancer. 36:522017. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Haigis MC, Deng CX, Finley LW, Kim HS and
Gius D: SIRT3 is a mitochondrial tumor suppressor: A scientific
tale that connects aberrant cellular ROS, the Warburg effect, and
carcinogenesis. Cancer Res. 72:2468–2472. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Sack MN and Finkel T: Mitochondrial
metabolism, sirtuins, and aging. Cold Spring Harb Perspect Biol.
4:a0131022012. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Michan S and Sinclair D: Sirtuins in
mammals: Insights into their biological function. Biochem J.
404:1–13. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Verdin E, Hirschey MD, Finley LW and
Haigis MC: Sirtuin regulation of mitochondria: Energy production,
apoptosis, and signaling. Trends Biochem Sci. 35:669–675. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Anderson KA and Hirschey MD: Mitochondrial
protein acetylation regulates metabolism. Essays Biochem. 52:23–35.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Alhazzazi TY, Kamarajan P, Joo N, Huang
JY, Verdin E, D'Silva NJ and Kapila YL: Sirtuin-3 (SIRT3), a novel
potential therapeutic target for oral cancer. Cancer.
117:1670–1678. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Shi T, Wang F, Stieren E and Tong Q:
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial
function and thermogenesis in brown adipocytes. J Biol Chemy.
280:13560–13567. 2005. View Article : Google Scholar
|
|
24
|
Kong X, Wang R, Xue Y, Liu X, Zhang H,
Chen Y, Fang F and Chang Y: Sirtuin 3, a new target of PGC-1alpha,
plays an important role in the suppression of ROS and mitochondrial
biogenesis. PLoS One. 5:e117072010. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Guarente L: Introduction: Sirtuins in
aging and diseases. Methods Mol Biol. 1077:3–10. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Resendis-Antonio O, Checa A and
Encarnacion S: Modeling core metabolism in cancer cells: Surveying
the topology underlying the Warburg effect. PLoS One. 5:e123832010.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Madhok BM, Yeluri S, Perry SL, Hughes TA
and Jayne DG: Targeting glucose metabolism: An emerging concept for
anticancer therapy. Am J Clin Oncol. 34:628–635. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Hirschey MD, Shimazu T, Goetzman E, Jing
E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S and
Ilkayeva OR: SIRT3 regulates mitochondrial fatty-acid oxidation by
reversible enzyme deacetylation. Nature. 464:121–125. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Bagul PK, Katare PB, Bugga P, Dinda AK and
Banerjee SK: SIRT-3 modulation by resveratrol improves
mitochondrial oxidative phosphorylation in diabetic heart through
deacetylation of TFAM. Cells. 7:2352018. View Article : Google Scholar
|
|
30
|
Dai SH, Chen T, Li X, Yue KY, Luo P, Yang
LK, Zhu J, Wang YH, Fei Z and Jiang XF: Sirt3 confers protection
against neuronal ischemia by inducing autophagy: Involvement of the
AMPK-mTOR pathway. Free Radic Biol Med. 108:345–353. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Pi H, Xu S, Reiter RJ, Guo P, Zhang L, Li
Y, Li M, Cao Z, Tian L, Xie J, et al: SIRT3-SOD2-mROS-dependent
autophagy in cadmium-induced hepatotoxicity and salvage by
melatonin. Autophagy. 11:1037–1051. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Li Y, Ma Y, Song L, Yu L, Zhang L, Zhang
Y, Xing Y, Yin Y and Ma H: SIRT3 deficiency exacerbates
p53/Parkin-mediated mitophagy inhibition and promotes mitochondrial
dysfunction: Implication for aged hearts. Int J Mol Med.
41:3517–3526. 2018.PubMed/NCBI
|
|
33
|
Edgett BA, Hughes MC, Matusiak JB, Perry
CG, Simpson CA and Gurd BJ: SIRT3 gene expression but not SIRT3
subcellular localization is altered in response to fasting and
exercise in human skeletal muscle. Exp Physiol. 101:1101–1113.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Chen Y, Fu LL, Wen X, Wang XY, Liu J,
Cheng Y and Huang J: Sirtuin-3 (SIRT3), a therapeutic target with
oncogenic and tumor-suppressive function in cancer. Cell Death Dis.
5:e10472014. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Dong XC, Jing LM, Wang WX and Gao YX:
Down-regulation of SIRT3 promotes ovarian carcinoma metastasis.
Biochem Biophys Res Commun. 475:245–250. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Yang Y, Cao Y, Chen L, Liu F, Qi Z, Cheng
X and Wang Z: Cryptotanshinone suppresses cell proliferation and
glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian
cancer cells. Cancer Med. 7:4610–4618. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Xiang XY, Kang JS, Yang XC, Su J, Wu Y,
Yan XY, Xue YN, Xu Y, Liu YH, Yu CY, et al: SIRT3 participates in
glucose metabolism interruption and apoptosis induced by BH3
mimetic S1 in ovarian cancer cells. Int J Oncol. 49:773–784. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Signorile A, De Rasmo D, Cormio A, Musicco
C, Rossi R, Fortarezza F, Palese LL, Loizzi V, Resta L, Scillitani
G, et al: Human ovarian cancer tissue exhibits increase of
mitochondrial biogenesis and cristae remodeling. Cancers (Basel).
11:13502019. View Article : Google Scholar
|
|
39
|
Hou L, Wang R, Wei H, Li S, Liu L, Lu X,
Yu H and Liu Z: ABT737 enhances ovarian cancer cells sensitivity to
cisplatin through regulation of mitochondrial fission via Sirt3
activation. Life Sci. 232:1165612019. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Li J, Yue H, Yu H, Lu X and Xue X:
Development and validation of SIRT3-related nomogram predictive of
overall survival in patients with serous ovarian cancer. J Ovarian
Res. 12:472019. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Yang Y and Klionsky DJ: Autophagy and
disease: Unanswered questions. Cell Death Differ. 27:858–871. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Wilde L, Tanson K, Curry J and
Martinez-Outschoorn U: Autophagy in cancer: A complex relationship.
Biochem J. 475:1939–1954. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Glick D, Barth S and Macleod KF:
Autophagy: Cellular and molecular mechanisms. J Pathol. 221:3–12.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Bednarczyk M, Zmarzly N, Grabarek B,
Mazurek U and Muc-Wierzgon M: Genes involved in the regulation of
different types of autophagy and their participation in cancer
pathogenesis. Oncotarget. 9:34413–34428. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Zhi X, Feng W, Rong Y and Liu R: Anatomy
of autophagy: From the beginning to the end. Cell Mol Life SciS.
75:815–831. 2018. View Article : Google Scholar
|
|
46
|
Burman C and Ktistakis NT: Autophagosome
formation in mammalian cells. Semin Immunopathol. 32:397–413. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Schaeffer V, Lavenir I, Ozcelik S, Tolnay
M, Winkler DT and Goedert M: Stimulation of autophagy reduces
neurodegeneration in a mouse model of human tauopathy. Brain.
135:2169–2177. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Liao X, Sluimer JC, Wang Y, Subramanian M,
Brown K, Pattison JS, Robbins J, Martinez J and Tabas I: Macrophage
autophagy plays a protective role in advanced atherosclerosis. Cell
Metab. 15:545–553. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Dikic I, Johansen T and Kirkin V:
Selective autophagy in cancer development and therapy. Cancer Res.
70:3431–3434. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Kim JJ, Lee HM, Shin DM, Kim W, Yuk JM,
Jin HS, Lee SH, Cha GH, Kim JM, Lee ZW, et al: Host cell autophagy
activated by antibiotics is required for their effective
antimycobacterial drug action. Cell Host Microbe. 11:457–468. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
White E and DiPaola RS: The double-edged
sword of autophagy modulation in cancer. Clin Cancer Res.
15:5308–5316. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Pu Z, Wu L, Guo Y, Li G, Xiang M, Liu L,
Zhan H, Zhou X and Tan H: LncRNA MEG3 contributes to
adenosine-induced cytotoxicity in hepatoma HepG2 cells by
downregulated ILF3 and autophagy inhibition via regulation
PI3K-AKT-mTOR and beclin-1 signaling pathway. J Cell Biochem.
120:18172–18185. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Li X, Lou X, Xu S, Wang Q, Shen M and Miao
J: Knockdown of miR-372 Inhibits nerve cell apoptosis induced by
spinal cord ischemia/reperfusion injury via enhancing autophagy by
Up-regulating Beclin-1. J Mol Neurosci. 66:437–444. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Cai M, Hu Z, Liu J, Gao J, Liu C, Liu D,
Tan M, Zhang D and Lin B: Beclin 1 expression in ovarian tissues
and its effects on ovarian cancer prognosis. Int J Mol Sci.
15:5292–5303. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Hennessy BT, Smith DL, Ram PT, Lu Y and
Mills GB: Exploiting the PI3K/AKT pathway for cancer drug
discovery. Nat Rev Drug Discov. 4:988–1004. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Fresno Vara JA, Casado E, de Castro J,
Cejas P, Belda-Iniesta C and Gonzalez-Baron M: PI3K/Akt signalling
pathway and cancer. Cancer Treat Rev. 30:193–204. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Carnero A, Blanco-Aparicio C, Renner O,
Link W and Leal JF: The PTEN/PI3K/AKT signalling pathway in cancer,
therapeutic implications. Curr Cancer Drug Targets. 8:187–198.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Arico S, Petiot A, Bauvy C, Dubbelhuis PF,
Meijer AJ, Codogno P and Ogier-Denis E: The tumor suppressor PTEN
positively regulates macroautophagy by inhibiting the
phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol
Chem. 276:35243–35246. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Li H, Zeng J and Shen K: PI3K/AKT/mTOR
signaling pathway as a therapeutic target for ovarian cancer. Arch
Gynecol Obstet. 290:1067–1078. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Hu L, Zaloudek C, Mills GB, Gray J and
Jaffe RB: In vivo and in vitro ovarian carcinoma growth inhibition
by a phosphatidylinositol 3-kinase inhibitor (LY294002). Clin
Cancer Res. 6:880–886. 2000.PubMed/NCBI
|
|
61
|
Engel JB, Schönhals T, Häusler S,
Krockenberger M, Schmidt M, Horn E, Köster F, Dietl J, Wischhusen J
and Honig A: Induction of programmed cell death by inhibition of
AKT with the alkylphosphocholine perifosine in in vitro models of
platinum sensitive and resistant ovarian cancers. Arch Gynecol
Obstet. 283:603–610. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Sun H, Yu T and Li J: Co-administration of
perifosine with paclitaxel synergistically induces apoptosis in
ovarian cancer cells: More than just AKT inhibition. Cancer Lett.
310:118–128. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Yu Y, Hall T, Eathiraj S, Wick MJ,
Schwartz B and Abbadessa G: In-vitro and in-vivo combined effect of
ARQ 092, an AKT inhibitor, with ARQ 087, a FGFR inhibitor.
Anticancer Drugs. 28:503–513. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Ichikawa K, Abe T, Nagase H, Saito H,
Fujita R, Okada M, Yonekura K, Shimomura T and Utsugi T: Abstract
C177: TAS-117, a highly selective non-ATP competitive inhibitor of
AKT demonstrated antitumor activity in combination with
chemotherapeutic agents and molecular targeted drugs. Mol Cancer
Ther. 12 (Suppl 11):C1772013.
|
|
65
|
Son Y, An Y, Jung J, Shin S, Park I, Gwak
J, Ju BG, Chung YH, Na M and Oh S: Protopine isolated from Nandina
domestica induces apoptosis and autophagy in colon cancer cells by
stabilizing p53. Phytother Res. 33:1689–1696. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Brooks CL and Gu W: Ubiquitination,
phosphorylation and acetylation: The molecular basis for p53
regulation. Curr Opin Cell Biol. 15:164–171. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Brooks CL and Gu W: The impact of
acetylation and deacetylation on the p53 pathway. Protein Cell.
2:456–462. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Feng Z, Hu W, de Stanchina E, Teresky AK,
Jin S, Lowe S and Levine AJ: The regulation of AMPK beta1, TSC2,
and PTEN expression by p53: Stress, cell and tissue specificity,
and the role of these gene products in modulating the
IGF-1-AKT-mTOR pathways. Cancer Res. 67:3043–3053. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Crighton D, Wilkinson S, O'Prey J, Syed N,
Smith P, Harrison PR, Gasco M, Garrone O, Crook T and Ryan KM:
DRAM, a p53-induced modulator of autophagy, is critical for
apoptosis. Cell. 126:121–134. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Tasdemir E, Maiuri MC, Galluzzi L, Vitale
I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C,
Harper F, et al: Regulation of autophagy by cytoplasmic p53. Nat
Cell Biol. 10:676–687. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Chen N and Karantza-Wadsworth V: Role and
regulation of autophagy in cancer. Biochim Biophys Acta.
1793:1516–1523. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Liang M and Zhao J: Protein expressions of
AIB1, p53 and Bcl-2 in epithelial ovarian cancer and their
correlations with the clinical pathological features and prognosis.
Eur Rev Med Pharmacol Sci. 22:5134–5139. 2018.PubMed/NCBI
|
|
73
|
Chen YN, Ren CC, Yang L, Nai MM, Xu YM,
Zhang F and Liu Y: MicroRNA let7d5p rescues ovarian cancer cell
apoptosis and restores chemosensitivity by regulating the p53
signaling pathway via HMGA1. Int J Oncol. 54:1771–1784.
2019.PubMed/NCBI
|
|
74
|
Cho CS, Lombard DB and Lee JH: SIRT3 as a
regulator of hepatic autophagy. Hepatology. 66:700–702. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Gao J, Feng Z, Wang X, Zeng M, Liu J, Han
S, Xu J, Chen L, Cao K, Long J, et al: SIRT3/SOD2 maintains
osteoblast differentiation and bone formation by regulating
mitochondrial stress. Cell Death Differ. 25:229–240. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Liu H, Li S, Liu X, Chen Y and Deng H:
SIRT3 overexpression inhibits growth of kidney tumor cells and
enhances mitochondrial biogenesis. J Proteome Res. 17:3143–3152.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Shi H, Deng HX, Gius D, Schumacker PT,
Surmeier DJ and Ma YC: Sirt3 protects dopaminergic neurons from
mitochondrial oxidative stress. Hum Mol Genet. 26:1915–1926. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Duran A, Amanchy R, Linares JF, Joshi J,
Abu-Baker S, Porollo A, Hansen M, Moscat J and Diaz-Meco MT: p62 is
a key regulator of nutrient sensing in the mTORC1 pathway. Mol
Cell. 44:134–146. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Wang ZG, Li H, Huang Y, Li R, Wang XF, Yu
LX, Guang XQ, Li L, Zhang HY, Zhao YZ, et al: Nerve growth
factor-induced Akt/mTOR activation protects the ischemic heart via
restoring autophagic flux and attenuating ubiquitinated protein
accumulation. Oncotarget. 8:5400–5413. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Ma Q, Zhang Z, Shim JK, Venkatraman TN,
Lascola CD, Quinones QJ, Mathew JP, Terrando N and Podgoreanu MV:
Annexin A1 bioactive peptide promotes resolution of
neuroinflammation in a rat model of exsanguinating cardiac arrest
treated by emergency preservation and resuscitation. Front
Neurosci. 13:6082019. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Tong W, Ju L, Qiu M, Xie Q, Chen Y, Shen
W, Sun W, Wang W and Tian J: Liraglutide ameliorates non-alcoholic
fatty liver disease by enhancing mitochondrial architecture and
promoting autophagy through the SIRT1/SIRT3-FOXO3a pathway. Hepatol
Res. 46:933–943. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Zhang M, Lin J, Wang S, Cheng Z, Hu J,
Wang T, Man W, Yin T, Guo W, Gao E, et al: Melatonin protects
against diabetic cardiomyopathy through Mst1/Sirt3 signaling. J
Pineal Res. May 8–2017.(Epub ahead of print). doi:
10.1111/jpi.12418. View Article : Google Scholar
|
|
83
|
Xiang X, Huang J, Song S, Wang Y, Zeng Y,
Wu S and Ruan Y: 17β-estradiol inhibits
H2O2-induced senescence in HUVEC cells
through upregulating SIRT3 expression and promoting autophagy.
Biogerontology. Mar 14–2020.(Epub ahead of print). doi:
10.1007/s10522-020-09868-w. View Article : Google Scholar
|
|
84
|
Zhang Y, Kwok-Shing Ng P, Kucherlapati M,
Chen F, Liu Y, Tsang YH, de Velasco G, Jeong KJ, Akbani R,
Hadjipanayis A, et al: A pan-cancer proteogenomic atlas of
PI3K/AKT/mTOR pathway alterations. Cancer Cell. 31:820–832.e3.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Sun Y, Huang YH, Huang FY, Mei WL, Liu Q,
Wang CC, Lin YY, Huang C, Li YN, Dai HF and Tan GH:
3′-epi-12β-hydroxyfroside, a new cardenolide, induces
cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in
lung cancer cells. Theranostics. 8:2044–2060. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Yang Q, Du WW, Wu N, Yang W, Awan FM, Fang
L, Ma J, Li X, Zeng Y, Yang Z, et al: A circular RNA promotes
tumorigenesis by inducing c-myc nuclear translocation. Cell Death
Differ. 24:1609–1620. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Quan Y, Wang N, Chen Q, Xu J, Cheng W, Di
M, Xia W and Gao WQ: SIRT3 inhibits prostate cancer by
destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt
pathway. Oncotarget. 6:26494–26507. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Wang G, Wang JJ, Wang YZ, Feng S, Jing G
and Fu XL: Myricetin nanoliposomes induced SIRT3-mediated
glycolytic metabolism leading to glioblastoma cell death. Artif
Cells Nanomed Biotechnol. 46 (Suppl 3):S180–S191. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Diotte NM, Xiong Y, Gao J, Chua BH and Ho
YS: Attenuation of doxorubicin-induced cardiac injury by
mitochondrial glutaredoxin 2. Biochim Biophys Acta. 1793:427–438.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Zhao M and Klionsky DJ: AMPK-dependent
phosphorylation of ULK1 induces autophagy. Cell Metab. 13:119–120.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Garcia D and Shaw RJ: AMPK: Mechanisms of
cellular energy sensing and restoration of metabolic balance. Mol
Cell. 66:789–800. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Inoki K, Kim J and Guan KL: AMPK and mTOR
in cellular energy homeostasis and drug targets. Annu Rev Pharmacol
Toxicol. 52:381–400. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Kim J, Kundu M, Viollet B and Guan KL:
AMPK and mTOR regulate autophagy through direct phosphorylation of
Ulk1. Nat Cell Biol. 13:132–141. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Zhao W, Zhang L, Chen R, Lu H, Sui M, Zhu
Y and Zeng L: SIRT3 protects against acute kidney injury via
AMPK/mTOR-regulated autophagy. Front Physiol. 9:15262018.
View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Inoki K, Zhu T and Guan KL: TSC2 mediates
cellular energy response to control cell growth and survival. Cell.
115:577–590. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Gwinn DM, Shackelford DB, Egan DF,
Mihaylova MM, Mery A, Vasquez DS, Turk BE and Shaw RJ: AMPK
phosphorylation of raptor mediates a metabolic checkpoint. Mol
Cell. 30:214–226. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Shackelford DB and Shaw RJ: The LKB1-AMPK
pathway: Metabolism and growth control in tumour suppression. Nat
Rev Cancer. 9:563–575. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Zhang M, Deng YN, Zhang JY, Liu J, Li YB,
Su H and Qu QM: SIRT3 protects rotenone-induced injury in SH-SY5Y
cells by promoting autophagy through the LKB1-AMPK-mTOR pathway.
Aging Dis. 9:273–286. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Bazhin AV, Philippov PP and Karakhanova S:
Reactive oxygen species in cancer biology and anticancer therapy.
Oxid Med Cell Longev. 2016:41978152016. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Shi L, Zhang T, Zhou Y, Zeng X, Ran L,
Zhang Q, Zhu J and Mi M: Dihydromyricetin improves skeletal muscle
insulin sensitivity by inducing autophagy via the
AMPK-PGC-1alpha-Sirt3 signaling pathway. Endocrine. 50:378–389.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Lv W, Sui L, Yan X, Xie H, Jiang L, Geng
C, Li Q, Yao X, Kong Y and Cao J: ROS-dependent Atg4 upregulation
mediated autophagy plays an important role in Cd-induced
proliferation and invasion in A549 cells. Chem Biol Interact.
279:136–144. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Li ZY, Yang Y, Ming M and Liu B:
Mitochondrial ROS generation for regulation of autophagic pathways
in cancer. Biochem Biophys Res Commun. 414:5–8. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Xia C, He Z, Liang S, Chen R, Xu W, Yang
J, Xiao G and Jiang S: Metformin combined with nelfinavir induces
SIRT3/mROS-dependent autophagy in human cervical cancer cells and
xenograft in nude mice. Eur J Pharmacol. 848:62–69. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Qiu X, Brown K, Hirschey MD, Verdin E and
Chen D: Calorie restriction reduces oxidative stress by
SIRT3-mediated SOD2 activation. Cell Metab. 12:662–667. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Tan WX, Xu TM, Zhou ZL, Lv XJ, Liu J,
Zhang WJ and Cui MH: TRP14 promotes resistance to cisplatin by
inducing autophagy in ovarian cancer. Oncol Rep. 42:1343–1354.
2019.
|
|
106
|
Qiu S, Sun L, Zhang Y and Han S:
Downregulation of BAG3 attenuates cisplatin resistance by
inhibiting autophagy in human epithelial ovarian cancer cells.
Oncol Lett. 18:1969–1978. 2019.PubMed/NCBI
|
|
107
|
Xie Z, Guo Z, Wang Y, Lei J and Yu J:
Protocatechuic acid inhibits the growth of ovarian cancer cells by
inducing apoptosis and autophagy. Phytother Res. 32:2256–2263.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Zhu H, Diao S, Lim V, Hu L and Hu J:
FAM83D inhibits autophagy and promotes proliferation and invasion
of ovarian cancer cells via PI3K/AKT/mTOR pathway. Acta Biochim
Biophys Sin (Shanghai). 51:509–516. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Wu Y, Gao WN, Xue YN, Zhang LC, Zhang JJ,
Lu SY, Yan XY, Yu HM, Su J and Sun LK: SIRT3 aggravates
metformin-induced energy stress and apoptosis in ovarian cancer
cells. Exp Cell Res. 367:137–149. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Zou G, Bai J, Li D and Chen Y: Effect of
metformin on the proliferation, apoptosis, invasion and autophagy
of ovarian cancer cells. Exp Ther Med. 18:2086–2094.
2019.PubMed/NCBI
|
|
111
|
Li X, Su J, Xia M, Li H, Xu Y, Ma C, Ma L,
Kang J, Yu H, Zhang Z and Sun L: Caspase-mediated cleavage of
Beclin1 inhibits autophagy and promotes apoptosis induced by S1 in
human ovarian cancer SKOV3 cells. Apoptosis. 21:225–238. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Liu N, Xu Y, Sun JT, Su J, Xiang XY, Yi
HW, Zhang ZC and Sun LK: The BH3 mimetic S1 induces endoplasmic
reticulum stress-associated apoptosis in cisplatin-resistant human
ovarian cancer cells although it activates autophagy. Oncol Rep.
30:2677–2684. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Yang X, Xiang X, Xia M, Su J, Wu Y, Shen
L, Xu Y and Sun L: Inhibition of JNK3 promotes apoptosis induced by
BH3 mimetic S1 in chemoresistant human ovarian cancer cells. Anat
Rec (Hoboken). 298:386–395. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Yang Y, Li N, Chen T, Zhang C, Li J, Liu
L, Qi Y, Zheng X, Zhang C and Bu P: Sirt3 promotes sensitivity to
sunitinib-induced cardiotoxicity via inhibition of
GTSP1/JNK/autophagy pathway in vivo and in vitro. Arch Toxicol.
93:3249–3260. 2019. View Article : Google Scholar : PubMed/NCBI
|
