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High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma

  • Authors:
    • Shanshan Lyu
    • Jiabin Lu
    • Wendan Chen
    • Weiye Huang
    • Haoqi Huang
    • Shaoyan Xi
    • Shumei Yan
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Lyu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 177
    |
    Published online on: August 31, 2020
       https://doi.org/10.3892/ol.2020.12038
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Abstract

Eukaryotic initiation factor 4A‑II (eIF4A2) is an ATP‑dependent RNA helicase involved in mRNA translation. Abnormal expression of eIF4A2 has been reported as a prognostic factor in different types of cancer. However, little is known regarding the function of eIF4A2 in esophageal squamous cell carcinoma (ESCC). In the present study, 253 samples were collected from patients diagnosed with ESCC, and the expression of eIF4A2 was detected by immunohistochemical staining. The clinicopathological and prognostic significance of eIF4A2 expression in ESCC were then statistically analyzed. The results demonstrated that eIF4A2 was specifically localized to the cytoplasm. Kaplan‑Meier analysis also revealed that eIF4A2 expression was associated with the clinical prognosis of patients with ESCC. The median disease‑free and overall survival times were 40 and 48 months for patients with low eIF4A2 expression, compared with 16 and 25 months in the high eIF4A2 expression group, respectively. In conclusion, high expression levels of eIF4A2 are associated with a poor prognosis and may be used as a potential prognostic indicator in patients with ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Lyu S, Lu J, Chen W, Huang W, Huang H, Xi S and Yan S: High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma. Oncol Lett 20: 177, 2020.
APA
Lyu, S., Lu, J., Chen, W., Huang, W., Huang, H., Xi, S., & Yan, S. (2020). High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma. Oncology Letters, 20, 177. https://doi.org/10.3892/ol.2020.12038
MLA
Lyu, S., Lu, J., Chen, W., Huang, W., Huang, H., Xi, S., Yan, S."High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma". Oncology Letters 20.5 (2020): 177.
Chicago
Lyu, S., Lu, J., Chen, W., Huang, W., Huang, H., Xi, S., Yan, S."High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma". Oncology Letters 20, no. 5 (2020): 177. https://doi.org/10.3892/ol.2020.12038
Copy and paste a formatted citation
x
Spandidos Publications style
Lyu S, Lu J, Chen W, Huang W, Huang H, Xi S and Yan S: High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma. Oncol Lett 20: 177, 2020.
APA
Lyu, S., Lu, J., Chen, W., Huang, W., Huang, H., Xi, S., & Yan, S. (2020). High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma. Oncology Letters, 20, 177. https://doi.org/10.3892/ol.2020.12038
MLA
Lyu, S., Lu, J., Chen, W., Huang, W., Huang, H., Xi, S., Yan, S."High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma". Oncology Letters 20.5 (2020): 177.
Chicago
Lyu, S., Lu, J., Chen, W., Huang, W., Huang, H., Xi, S., Yan, S."High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma". Oncology Letters 20, no. 5 (2020): 177. https://doi.org/10.3892/ol.2020.12038
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