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A novel definition of microvessel density in renal cell carcinoma: Angiogenesis plus vasculogenic mimicry

  • Authors:
    • Yanyuan Wu
    • Kun Du
    • Wenbin Guan
    • Di Wu
    • Haixiao Tang
    • Ning Wang
    • Jun Qi
    • Zhengqin Gu
    • Junyao Yang
    • Jie Ding
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200092, P.R. China, Department of Laboratory, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200092, P.R. China, Department of Pathology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200092, P.R. China, Department of Urology, The People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 192
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    Published online on: September 3, 2020
       https://doi.org/10.3892/ol.2020.12054
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Abstract

The present study proposed the novel concept of total microvessel density (TMVD), which is the combination of the MVD and the vasculogenic mimicry (VM) status, and evaluated its clinical significance in patients with renal cell carcinoma (RCC). For that purpose, tumor samples from 183 patients with primary RCC were examined by CD34 single or periodic acid Schiff (PAS)/CD34 dual histology staining. MVD and VM were determined according to previous literature. Clinical information (tumor stage and grade, and duration of survival) was retrieved and analyzed. Survival information and VM‑associated gene expression data of patients with RCC were also retrieved from The Cancer Genome Atlas (TCGA) database and the clinical significance of each individual gene was analyzed. The results indicated that MVD exhibited obvious differences among patients with RCC; however, it was not correlated with the stage/grade or length of survival in patients with RCC. In total, 81 patients (44.3%) were CD34(‑)/PAS(+) and defined as VM(+), and they had a significantly shorter survival compared with that of VM(‑) patients (P=0.0002). VM was not associated with MVD. TMVD was able to distinguish between patients with high and low MVD in terms of survival, thus TMVD was better compared with MVD alone at distinguishing between patients with different survival prognoses. TCGA data analysis revealed that among the VM‑associated genes, nodal growth differentiation factor, caspase‑3, matrix metalloproteinase‑9 and galectin‑3 had a statistically significant impact on the overall/disease‑free survival of patients with RCC. In conclusion, the TMVD concept may be more appropriate and sensitive compared with the MVD or VM alone in predicting tumor aggressiveness and patient survival, particularly in RCC, which is a highly vascularized, VM‑rich neoplasm, and certain VM formation‑associated genes are negatively associated with the survival of patients with RCC.
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1 

Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1:27–31. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Folkman J: Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 29 (6 Suppl 16):S15–S18. 2002. View Article : Google Scholar

3 

Folkman J: Anti-angiogenesis: New concept for therapy of solid tumors. Ann Surg. 175:409–416. 1972. View Article : Google Scholar : PubMed/NCBI

4 

Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature. 407:249–257. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Hlatky L, Hahnfeldt P and Folkman J: Clinical application of antiangiogenic therapy: Microvessel density, what it does and doesn't tell us. J Natl Cancer Inst. 94:883–893. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Tae K, El-Naggar AK, Yoo E, Feng L, Lee JJ, Hong WK, Hittelman WN and Shin DM: Expression of vascular endothelial growth factor and microvessel density in head and neck tumorigenesis. Clin Cancer Res. 6:2821–2828. 2000.PubMed/NCBI

7 

Zhou D, Cheng SQ, Ji HF, Wang JS, Xu HT, Zhang GQ and Pang D: Evaluation of protein pigment epithelium-derived factor (PEDF) and microvessel density (MVD) as prognostic indicators in breast cancer. J Cancer Res Clin Oncol. 136:1719–1727. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Pastushenko I, Vermeulen PB, Carapeto FJ, Van den Eynden G, Rutten A, Ara M, Dirix LY and Van Laere S: Blood microvessel density, lymphatic microvessel density and lymphatic invasion in predicting melanoma metastases: Systematic review and meta-analysis. Br J Dermatol. 170:66–77. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Miyata Y and Sakai H: Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement. Int J Urol. 22:806–815. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Huang J, Ma X, Chen X, Liu X, Zhang B, Minmin L, Nie W, Zhang L and Liu L: Microvessel density as a prognostic factor in bladder cancer: A systematic review of literature and meta-analysis. Cancer Biomark. 14:505–514. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Aziz SA, Sznol J, Adeniran A, Colberg JW, Camp RL and Kluger HM: Vascularity of primary and metastatic renal cell carcinoma specimens. J Transl Med. 11:152013. View Article : Google Scholar : PubMed/NCBI

12 

Derosa L, Bayar MA, Albiges L, Le Teuff G and Escudier B: A new prognostic model for survival in second line for metastatic renal cell carcinoma: Development and external validation. Angiogenesis. 22:383–395. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Nativ O, Sabo E, Reiss A, Wald M, Madjar S and Moskovitz B: Clinical significance of tumor angiogenesis in patients with localized renal cell carcinoma. Urology. 51:693–696. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Fukata S, Inoue K, Kamada M, Kawada C, Furihata M, Ohtsuki Y and Shuin T: Levels of angiogenesis and expression of angiogenesis-related genes are prognostic for organ-specific metastasis of renal cell carcinoma. Cancer. 103:931–942. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Joo H, Oh D, Kim Y, Lee K and Kim S: Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma. BJU Int. 93:291–296. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Minardi D, Lucarini G, Filosa A, Milanese G, Zizzi A, Di Primio R, Montironi R and Muzzonigro G: Prognostic role of tumor necrosis, microvessel density, vascular endothelial growth factor and hypoxia inducible factor-1alpha in patients with clear cell renal carcinoma after radical nephrectomy in a long term follow-up. Int J Immunopathol Pharmacol. 21:447–455. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Iakovlev VV, Gabril M, Dubinski W, Scorilas A, Youssef YM, Faragalla H, Kovacs K, Rotondo F, Metias S, Arsanious A, et al: Microvascular density as an independent predictor of clinical outcome in renal cell carcinoma: An automated image analysis study. Lab Invest. 92:46–56. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Paradis V, Lagha NB, Zeimoura L, Blanchet P, Eschwege P, Ba N, Benoît G, Jardin A and Bedossa P: Expression of vascular endothelial growth factor in renal cell carcinomas. Virchows Arch. 436:351–356. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Zhang X, Yamashita M, Uetsuki H and Kakehi Y: Angiogenesis in renal cell carcinoma: Evaluation of microvessel density, vascular endothelial growth factor and matrix metalloproteinases. Int J Urol. 9:509–514. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Tuna B, Yorukoglu K, Unlu M, Mungan MU and Kirkali Z: Association of mast cells with microvessel density in renal cell carcinomas. Eur Urol. 50:530–534. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Slaton JW, Inoue K, Perrotte P, El-Naggar AK, Swanson DA, Fidler IJ and Dinney CP: Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma. Am J Pathol. 158:735–743. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Mohseni MG, Mohammadi A, Heshmat AS, Kosari F and Meysamie AP: The lack of correlation between mast cells and microvessel density with pathologic feature of renal cell carcinoma. Int Urol Nephrol. 42:109–112. 2010. View Article : Google Scholar : PubMed/NCBI

23 

MacLennan GT and Bostwick DG: Microvessel density in renal cell carcinoma: Lack of prognostic significance. Urology. 46:27–30. 1995. View Article : Google Scholar : PubMed/NCBI

24 

Gelb AB, Sudilovsky D, Wu CD, Weiss LM and Medeiros LJ: Appraisal of intratumoral microvessel density, MIB-1 score, DNA content, and p53 protein expression as prognostic indicators in patients with locally confined renal cell carcinoma. Cancer. 80:1768–1775. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Suzuki K, Morita T, Hashimoto S and Tokue A: Thymidine phosphorylase/platelet-derived endothelial cell growth factor (PD-ECGF) associated with prognosis in renal cell carcinoma. Urol Res. 29:7–12. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Minardi D, Lucarini G, Mazzucchelli R, Milanese G, Natali D, Galosi AB, Montironi R, Biagini G and Muzzonigro G: Prognostic role of fuhrman grade and vascular endothelial growth factor in pT1a clear cell carcinoma in partial nephrectomy specimens. J Urol. 174:1208–1212. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Anastassiou G, Duensing S, Steinhoff G, Zorn U, Grosse J, Dallmann I, Kirchner H, Ganser A and Atzpodien J: Platelet endothelial cell adhesion molecule-1 (PECAM-1): A potential prognostic marker involved in leukocyte infiltration of renal cell carcinoma. Oncology. 53:127–132. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Rioux-Leclercq N, Epstein JI, Bansard JY, Turlin B, Patard JJ, Manunta A, Chan T, Ramee MP, Lobel B and Moulinoux JP: Clinical significance of cell proliferation, microvessel density, and CD44 adhesion molecule expression in renal cell carcinoma. Hum Pathol. 32:1209–1215. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Yagasaki H, Kawata N, Takimoto Y and Nemoto N: Histopathological analysis of angiogenic factors in renal cell carcinoma. Int J Urol. 10:220–227. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Imao T, Egawa M, Takashima H, Koshida K and Namiki M: Inverse correlation of microvessel density with metastasis and prognosis in renal cell carcinoma. Int J Urol. 11:948–953. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Mertz KD, Demichelis F, Kim R, Schraml P, Storz M, Diener PA, Moch H and Rubin MA: Automated immunofluorescence analysis defines microvessel area as a prognostic parameter in clear cell renal cell cancer. Hum Pathol. 38:1454–1462. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Yildiz E, Ayan S, Goze F, Gokce G and Gultekin EY: Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma. BJU Int. 101:758–764. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Yoshino S, Kato M and Okada K: Prognostic significance of microvessel count in low stage renal cell carcinoma. Int J Urol. 2:156–160. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Sabo E, Boltenko A, Sova Y, Stein A, Kleinhaus S and Resnick MB: Microscopic analysis and significance of vascular architectural complexity in renal cell carcinoma. Clin Cancer Res. 7:533–537. 2001.PubMed/NCBI

35 

Delahunt B, Bethwaite P and Thornton A: Prognostic significance of microscopic vascularity for clear cell renal cell carcinoma. Br J Urol. 80:401–404. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Schraml P, Struckmann K, Hatz F, Sonnet S, Kully C, Gasser T, Sauter G, Mihatsch MJ and Moch H: VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma. J Pathol. 196:186–193. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Sandlund J, Hedberg Y, Bergh A, Grankvist K, Ljungberg B and Rasmuson T: Endoglin (CD105) expression in human renal cell carcinoma. BJU Int. 97:706–710. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Sandlund J, Hedberg Y, Bergh A, Grankvist K, Ljungberg B and Rasmuson T: Evaluation of CD31 (PECAM-1) expression using tissue microarray in patients with renal cell carcinoma. Tumor Biol. 28:158–164. 2007. View Article : Google Scholar

39 

Köhler HH, Barth PJ, Siebel A, Gerharz EW and Bittinger A: Quantitative assessment of vascular surface density in renal cell carcinomas. Br J Urol. 77:650–654. 1996. View Article : Google Scholar : PubMed/NCBI

40 

Hemmerlein B, Kugler A, Özisik R, Ringert RH, Radzun HJ and Thelen P: Vascular endothelial growth factor expression, angiogenesis, and necrosis in renal cell carcinomas. Virchows Arch. 439:645–652. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Baldewijns MM, Thijssen VL, Van den Eynden GG, Van Laere SJ, Bluekens AM, Roskams T, van Poppel H, De Bruïne AP, Griffioen AW and Vermeulen PB: High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile. Br J Cancer. 96:1888–1895. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Kavantzas N, Paraskevakou H, Tseleni-Balafouta S, Aroni K, Athanassiades P, Agrogiannis G and Patsouris E: Association between microvessel density and histologic grade in renal cell carcinomas. Pathol Oncol Res. 13:145–148. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Sharma SG, Aggarwal N, Gupta SD, Singh MK, Gupta R and Dinda AK: Angiogenesis in renal cell carcinoma: Correlation of microvessel density and microvessel area with other prognostic factors. Int Urol Nephrol. 43:125–129. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Weidner N: Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol. 147:91995.PubMed/NCBI

45 

Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LM, Pe'er J, Trent JM, Meltzer PS and Hendrix MJ: Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry. Am J Pathol. 155:739–752. 1999. View Article : Google Scholar : PubMed/NCBI

46 

Shirakawa K, Kobayashi H, Heike Y, Kawamoto S, Brechbiel MW, Kasumi F, Iwanaga T, Konishi F, Terada M and Wakasugi H: Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft. Cancer Res. 62:560–566. 2002.PubMed/NCBI

47 

Sun B, Zhang S, Zhang D, Du J, Guo H, Zhao X, Zhang W and Hao X: Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma. Oncol Rep. 16:693–698. 2006.PubMed/NCBI

48 

Lee H, Lee M, Lee SE, Byun SS, Kim HH, Kwak C and Hong SK: Outcomes of pathologic stage T3a renal cell carcinoma up-staged from small renal tumor: Emphasis on partial nephrectomy. BMC Cancer. 18:4272018. View Article : Google Scholar : PubMed/NCBI

49 

Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, et al: Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 21:425–532. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Feng Y, Song K, Shang W, Chen L, Wang C, Pang B and Wang N: REDD1 overexpression in oral squamous cell carcinoma may predict poor prognosis and correlates with high microvessel density. Oncol Lett. 19:431–441. 2020.PubMed/NCBI

51 

Vartanian AA, Stepanova EV, Gutorov SL, Solomko ES, Grigorieva IN, Sokolova IN, Baryshnikov AY and Lichinitser MR: Prognostic significance of periodic acid-Schiff-positive patterns in clear cell renal cell carcinoma. Can J Urol. 16:4726–4732. 2009.PubMed/NCBI

52 

Zhang Y, Sun B, Zhao X, Liu Z, Wang X, Yao X, Dong X and Chi J: Clinical significances and prognostic value of cancer stem-like cells markers and vasculogenic mimicry in renal cell carcinoma. J Surg Oncol. 108:414–419. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Qiao L, Liang N, Zhang J, Xie J, Liu F, Xu D, Yu X and Tian Y: Advanced research on vasculogenic mimicry in cancer. J Cell Mol Med. 19:315–326. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Paulis YW, Soetekouw PM, Verheul HM, Tjan-Heijnen VC and Griffioen AW: Signalling pathways in vasculogenic mimicry. Biochim Biophys Acta. 1806:18–28. 2010.PubMed/NCBI

55 

Kirschmann DA, Seftor EA, Hardy KM, Seftor RE and Hendrix MJ: Molecular pathways: Vasculogenic mimicry in tumor cells: Diagnostic and therapeutic implications. Clin Cancer Res. 18:2726–2732. 2012. View Article : Google Scholar : PubMed/NCBI

56 

Bai J, Yeh S, Qiu X, Hu L, Zeng J, Cai Y, Zuo L, Li G, Yang G and Chang C: TR4 nuclear receptor promotes clear cell renal cell carcinoma (ccRCC) vasculogenic mimicry (VM) formation and metastasis via altering the miR490-3p/vimentin signals. Oncogene. 37:5901–5912. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Sabo E, Miselevich I, Bejar J, Segenreich M, Wald M, Moskovitz B and Nativ O: The role of vimentin expression in predicting the long-term outcome of patients with localized renal cell carcinoma. Br J Urol. 80:864–868. 1997. View Article : Google Scholar : PubMed/NCBI

58 

Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med. 324:1–8. 1991. View Article : Google Scholar : PubMed/NCBI

59 

Sandlund J, Hedberg Y, Bergh A, Grankvist K, Ljungberg B and Rasmuson T: Endoglin (CD105) expression in human renal cell carcinoma. BJU Int. 97:706–710. 2006. View Article : Google Scholar : PubMed/NCBI

60 

Sandlund J, Hedberg Y, Bergh A, Grankvist K, Ljungberg B and Rasmuson T: Evaluation of CD31 (PECAM-1) expression using tissue microarray in patients with renal cell carcinoma. Tumour Biol. 28:158–164. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Yao X, Qian CN, Zhang ZF, Tan MH, Kort EJ, Yang XJ, Resau JH and The BT: Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications. Clin Cancer Res. 13:161–169. 2007. View Article : Google Scholar : PubMed/NCBI

62 

Qian CN, Huang D, Wondergem B and Teh BT: Complexity of tumor vasculature in clear cell renal cell carcinoma. Cancer. 115 (10 Suppl):S2282–S2289. 2009. View Article : Google Scholar

63 

Kuczynski EA and Reynolds AR: Vessel co-option and resistance to anti-angiogenic therapy. Angiogenesis. 23:55–74. 2020. View Article : Google Scholar : PubMed/NCBI

64 

Kuczynski EA, Vermeulen PB, Pezzella F, Kerbel RS and Reynolds AR: Vessel co-option in cancer. Nat Rev Clin Oncol. 16:469–493. 2019. View Article : Google Scholar : PubMed/NCBI

65 

Latacz E, Caspani E, Barnhill R, Lugassy C, Verhoef C, Grünhagen D, Van Laere S, Moro CF, Gerling M, Dirix M, et al: Pathological features of vessel co-option versus sprouting angiogenesis. Angiogenesis. 23:43–54. 2020. View Article : Google Scholar : PubMed/NCBI

66 

Yang JP, Liao YD, Mai DM, Xie P, Qiang YY, Zheng LS, Wang MY, Mei Y, Meng DF, Xu L, et al: Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: A meta-analysis. Angiogenesis. 19:191–200. 2016. View Article : Google Scholar : PubMed/NCBI

67 

Hueng DY, Lin GJ, Huang SH, Liu LW, Ju DT, Chen YW, Sytwu HK, Chang C, Huang SM, Yeh YS, et al: Inhibition of Nodal suppresses angiogenesis and growth of human gliomas. J Neurooncol. 104:21–31. 2011. View Article : Google Scholar : PubMed/NCBI

68 

Feng X, Yu Y, He S, Cheng J, Gong Y, Zhang Z, Yang X, Xu B, Liu X, Li CY, et al: Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. Cancer Lett. 385:12–20. 2017. View Article : Google Scholar : PubMed/NCBI

69 

Bekes EM, Schweighofer B, Kupriyanova TA, Zajac E, Ardi VC, Quigley JP and Deryugina EI: Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation. Am J Pathol. 179:1455–1470. 2011. View Article : Google Scholar : PubMed/NCBI

70 

Jia W, Kidoya H, Yamakawa D, Naito H and Takakura N: Galectin-3 accelerates M2 macrophage infiltration and angiogenesis in tumors. Am J Pathol. 182:1821–1831. 2013. View Article : Google Scholar : PubMed/NCBI

71 

Bentley K, Franco CA, Philippides A, Blanco R, Dierkes M, Gebala V, Stanchi F, Jones M, Aspalter IM, Cagna G, et al: The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat Cell Biol. 16:309–321. 2014. View Article : Google Scholar : PubMed/NCBI

72 

Wang JY, Sun T, Zhao XL, Zhang SW, Zhang DF, Gu Q, Wang XH, Zhao N, Qie S and Sun BC: Functional significance of VEGF-a in human ovarian carcinoma: Role in vasculogenic mimicry. Cancer Biol Ther. 7:758–766. 2008. View Article : Google Scholar : PubMed/NCBI

73 

Motzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, Plimack ER, Barthélémy P, Porta C, George S, et al: Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma. N Engl J Med. 378:1277–1290. 2018. View Article : Google Scholar : PubMed/NCBI

74 

Powles T, Albiges L, Staehler M, Bensalah K, Dabestani S, Giles RH, Hofmann F, Hora M, Kuczyk MA, Lam TB, et al: Updated european association of urology guidelines recommendations for the treatment of first-line metastatic clear cell renal cancer. Eur Urol. 73:311–315. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Azuma T, Sugihara T, Honda S, Yoshizaki U, Niimi F, Tsuru I and Kume H: Metastatic renal cell carcinoma regains sensitivity to tyrosine kinase inhibitor after nivolumab treatment: A case report. Oncol Lett. 17:4011–4015. 2019.PubMed/NCBI

76 

Wei W, Lv Y, Gan Z, Zhang Y, Han X and Xu Z: Identification of key genes involved in the metastasis of clear cell renal cell carcinoma. Oncol Lett. 17:4321–4328. 2019.PubMed/NCBI

77 

Carlsson J, Christiansen J, Davidsson S, Giunchi F, Fiorentino M and Sundqvist P: The potential role of miR-126, miR-21 and miR-10b as prognostic biomarkers in renal cell carcinoma. Oncol Lett. 17:4566–4574. 2019.PubMed/NCBI

78 

Gao Y, Qi JC, Li X, Sun JP, Ji H and Li QH: Decreased expression of TXNIP predicts poor prognosis in patients with clear cell renal cell carcinoma. Oncol Lett. 19:763–770. 2020.PubMed/NCBI

79 

Yan N, Feng X, Jiang S, Sun W, Sun MZ and Liu S: GRIM-19 deficiency promotes clear cell renal cell carcinoma progression and is associated with high TNM stage and fuhrman grade. Oncol Lett. 19:4115–4121. 2020.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Du K, Guan W, Wu D, Tang H, Wang N, Qi J, Gu Z, Yang J, Ding J, Ding J, et al: A novel definition of microvessel density in renal cell carcinoma: Angiogenesis plus vasculogenic mimicry. Oncol Lett 20: 192, 2020.
APA
Wu, Y., Du, K., Guan, W., Wu, D., Tang, H., Wang, N. ... Ding, J. (2020). A novel definition of microvessel density in renal cell carcinoma: Angiogenesis plus vasculogenic mimicry. Oncology Letters, 20, 192. https://doi.org/10.3892/ol.2020.12054
MLA
Wu, Y., Du, K., Guan, W., Wu, D., Tang, H., Wang, N., Qi, J., Gu, Z., Yang, J., Ding, J."A novel definition of microvessel density in renal cell carcinoma: Angiogenesis plus vasculogenic mimicry". Oncology Letters 20.5 (2020): 192.
Chicago
Wu, Y., Du, K., Guan, W., Wu, D., Tang, H., Wang, N., Qi, J., Gu, Z., Yang, J., Ding, J."A novel definition of microvessel density in renal cell carcinoma: Angiogenesis plus vasculogenic mimicry". Oncology Letters 20, no. 5 (2020): 192. https://doi.org/10.3892/ol.2020.12054
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Du K, Guan W, Wu D, Tang H, Wang N, Qi J, Gu Z, Yang J, Ding J, Ding J, et al: A novel definition of microvessel density in renal cell carcinoma: Angiogenesis plus vasculogenic mimicry. Oncol Lett 20: 192, 2020.
APA
Wu, Y., Du, K., Guan, W., Wu, D., Tang, H., Wang, N. ... Ding, J. (2020). A novel definition of microvessel density in renal cell carcinoma: Angiogenesis plus vasculogenic mimicry. Oncology Letters, 20, 192. https://doi.org/10.3892/ol.2020.12054
MLA
Wu, Y., Du, K., Guan, W., Wu, D., Tang, H., Wang, N., Qi, J., Gu, Z., Yang, J., Ding, J."A novel definition of microvessel density in renal cell carcinoma: Angiogenesis plus vasculogenic mimicry". Oncology Letters 20.5 (2020): 192.
Chicago
Wu, Y., Du, K., Guan, W., Wu, D., Tang, H., Wang, N., Qi, J., Gu, Z., Yang, J., Ding, J."A novel definition of microvessel density in renal cell carcinoma: Angiogenesis plus vasculogenic mimicry". Oncology Letters 20, no. 5 (2020): 192. https://doi.org/10.3892/ol.2020.12054
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