Open Access

MicroRNA‑3690 promotes cell proliferation and cell cycle progression by altering DKK3 expression in human thyroid cancer

  • Authors:
    • Fei Shen
    • Xiao-Xiong Gan
    • Xing-Yan Deng
    • Jian-Hua Feng
    • Wen-Song Cai
    • Liang Shen
    • Huan-Qing Xiao
    • Bo Xu
  • View Affiliations

  • Published online on: September 10, 2020     https://doi.org/10.3892/ol.2020.12086
  • Article Number: 223
  • Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

An increasing amount of evidence has demonstrated the importance of microRNAs (miRNAs/miRs) in the tumorigenesis of malignant types of cancer, and data retrieved from The Cancer Genome Atlas database revealed that miR‑3690 was upregulated in thyroid cancer (TC). The present study focused on the biological function and mechanism of miR‑3690 in TC, demonstrating that miR‑3690 expression was significantly elevated in TC cells and clinical tissues. Functional studies indicated that miR‑3690 acted as an oncogene in TC by promoting cell proliferation, colony formation and cell cycle progression in association with the increased expression of cyclin E and c‑myc. Mechanistically, prediction software indicated that Dickkopf‑related protein 3 (DKK3) was a target of miR‑3690, which was confirmed by the results of luciferase reporter assays and western blotting. DKK3 silencing abrogated the functions of miR‑3690‑in on TC cell proliferation. Collectively, the findings of the present study demonstrated that miR‑3690 promoted TC cell proliferation and indicated miR‑3690 as a potential biomarker and therapeutic target for TC.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Shen F, Gan X, Deng X, Feng J, Cai W, Shen L, Xiao H and Xu B: MicroRNA‑3690 promotes cell proliferation and cell cycle progression by altering DKK3 expression in human thyroid cancer. Oncol Lett 20: 223, 2020
APA
Shen, F., Gan, X., Deng, X., Feng, J., Cai, W., Shen, L. ... Xu, B. (2020). MicroRNA‑3690 promotes cell proliferation and cell cycle progression by altering DKK3 expression in human thyroid cancer. Oncology Letters, 20, 223. https://doi.org/10.3892/ol.2020.12086
MLA
Shen, F., Gan, X., Deng, X., Feng, J., Cai, W., Shen, L., Xiao, H., Xu, B."MicroRNA‑3690 promotes cell proliferation and cell cycle progression by altering DKK3 expression in human thyroid cancer". Oncology Letters 20.5 (2020): 223.
Chicago
Shen, F., Gan, X., Deng, X., Feng, J., Cai, W., Shen, L., Xiao, H., Xu, B."MicroRNA‑3690 promotes cell proliferation and cell cycle progression by altering DKK3 expression in human thyroid cancer". Oncology Letters 20, no. 5 (2020): 223. https://doi.org/10.3892/ol.2020.12086