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Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma (Review)

  • Authors:
    • Yu Zhang
    • Chengzhong Lin
    • Xu Wang
    • Tong Ji
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 253
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    Published online on: September 18, 2020
       https://doi.org/10.3892/ol.2020.12116
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Abstract

Nerves have been widely demonstrated to exert major effects in tumor‑associated microenvironments. Due to the characteristic innervation of the oral cavity and the fact that cancer‑associated pain is a distinct feature of oral squamous cell carcinoma (OSCC), the sensory nerves may dominate in the OSCC‑nerve microenvironment. As the most abundant neuropeptide in the trigeminal ganglion, the calcitonin gene‑related peptide (CGRP) exerts a dual effect on cancer development and cancer‑associated pain in various types of cancer. The present review explored the potential molecular mechanisms of the roles of CGRP in cancer development and cancer‑associated pain, suggesting that CGRP may be a promising therapeutic target for OSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Lin C, Wang X and Ji T: Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma (Review). Oncol Lett 20: 253, 2020.
APA
Zhang, Y., Lin, C., Wang, X., & Ji, T. (2020). Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma (Review). Oncology Letters, 20, 253. https://doi.org/10.3892/ol.2020.12116
MLA
Zhang, Y., Lin, C., Wang, X., Ji, T."Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma (Review)". Oncology Letters 20.5 (2020): 253.
Chicago
Zhang, Y., Lin, C., Wang, X., Ji, T."Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma (Review)". Oncology Letters 20, no. 5 (2020): 253. https://doi.org/10.3892/ol.2020.12116
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Lin C, Wang X and Ji T: Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma (Review). Oncol Lett 20: 253, 2020.
APA
Zhang, Y., Lin, C., Wang, X., & Ji, T. (2020). Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma (Review). Oncology Letters, 20, 253. https://doi.org/10.3892/ol.2020.12116
MLA
Zhang, Y., Lin, C., Wang, X., Ji, T."Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma (Review)". Oncology Letters 20.5 (2020): 253.
Chicago
Zhang, Y., Lin, C., Wang, X., Ji, T."Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma (Review)". Oncology Letters 20, no. 5 (2020): 253. https://doi.org/10.3892/ol.2020.12116
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