Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma (Review)
- Authors:
- Yu Zhang
- Chengzhong Lin
- Xu Wang
- Tong Ji
-
Affiliations: Department of Oral and Maxillofacial Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China - Published online on: September 18, 2020 https://doi.org/10.3892/ol.2020.12116
- Article Number: 253
-
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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|
Senthebane DA, Rowe A, Thomford NE, Shipanga H, Munro D, Mazeedi MAMA, Almazyadi HAM, Kallmeyer K, Dandara C, Pepper MS, et al: The role of tumor microenvironment in chemoresistance: To survive, keep your enemies closer. Int J Mol Sci. 18:15862017. View Article : Google Scholar | |
|
Yadav L, Puri N, Rastogi V, Satpute P and Sharma V: Tumour angiogenesis and angiogenic inhibitors: A review. J Clin Diagn Res. 9:XE01–XE05. 2015.PubMed/NCBI | |
|
Boilly B, Faulkner S, Jobling P and Hondermarck H: Nerve dependence: From regeneration to cancer. Cancer Cell. 31:342–354. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Amit M, Takahashi H, Dragomir MP, Lindemann A, Gleber-Netto FO, Pickering CR, Anfossi S, Osman AA, Cai Y, Wang R, et al: Loss of p53 drives neuron reprogramming in head and neck cancer. Nature. 578:449–454. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Mauffrey P, Tchitchek N, Barroca V, Bemelmans AP, Firlej V, Allory Y, Roméo PH and Magnon C: Progenitors from the central nervous system drive neurogenesis in cancer. Nature. 569:672–678. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Rogers SN, Brown JS, Woolgar JA, Lowe D, Magennis P, Shaw RJ, Sutton D, Errington D and Vaughan D: Survival following primary surgery for oral cancer. Oral Oncol. 45:201–211. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Mu L and Sanders I: Human tongue neuroanatomy: Nerve supply and motor endplates. Clin Anat. 23:777–791. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Bagan J, Sarrion G and Jimenez Y: Oral cancer: Clinical features. Oral Oncol. 46:414–417. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Reyes-Gibby CC, Anderson KO, Merriman KW, Todd KH, Shete SS and Hanna EY: Survival patterns in squamous cell carcinoma of the head and neck: Pain as an independent prognostic factor for survival. J Pain. 15:1015–1022. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
van den Beuken-van Everdingen MH, de Rijke JM, Kessels AG, Schouten HC, van Kleef M and Patijn J: Prevalence of pain in patients with cancer: A systematic review of the past 40 years. Ann Oncol. 18:1437–1449. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Zahalka AH and Frenette PS: Nerves in cancer. Nat Rev Cancer. 20:143–157. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Drissi H, Lieberherr M, Hott M, Marie PJ and Lasmoles F: Calcitonin gene-related peptide (CGRP) increases intracellular free Ca2+ concentrations but not cyclic AMP formation in CGRP receptor-positive osteosarcoma cells (OHS-4). Cytokine. 11:200–207. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Papantoniou V, Tsiouris S, Sotiropoulou M, Valsamaki P, Koutsikos J, Ptohis N, Dimitrakakis C, Sotiropoulou E, Melissinou M, Nakopoulou L, et al: The potential role of calcitonin gene-related peptide (CGRP) in breast carcinogenesis and its correlation with 99mTc-(V)DMSA scintimammography. Am J Clin Oncol. 30:420–427. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Eftekhari S, Salvatore CA, Calamari A, Kane SA, Tajti J and Edvinsson L: Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion. Neuroscience. 169:683–696. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Brain SD and Grant AD: Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev. 84:903–934. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Russell FA, King R, Smillie SJ, Kodji X and Brain SD: Calcitonin gene-related peptide: Physiology and pathophysiology. Physiol Rev. 94:1099–1142. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Rosenfeld MG, Mermod JJ, Amara SG, Swanson LW, Sawchenko PE, Rivier J, Vale WW and Evans RM: Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature. 304:129–135. 1983. View Article : Google Scholar : PubMed/NCBI | |
|
McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG and Foord SM: RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 393:333–339. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Luebke AE, Dahl GP, Roos BA and Dickerson IM: Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay. Proc Natl Acad Sci USA. 93:3455–3460. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Negro A and Martelletti P: Gepants for the treatment of migraine. Expert Opin Investig Drugs. 28:555–567. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Edvinsson L, Haanes KA, Warfvinge K and Krause DN: CGRP as the target of new migraine therapies-successful translation from bench to clinic. Nat Rev Neurol. 14:338–350. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ferrari MD, Diener HC, Ning X, Galic M, Cohen JM, Yang R, Mueller M, Ahn AH, Schwartz YC, Grozinski-Wolff M, et al: Fremanezumab versus placebo for migraine prevention in patients with documented failure to up to four migraine preventive medication classes (FOCUS): A randomised, double-blind, placebo-controlled, phase 3b trial. Lancet. 394:1030–1040. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Goadsby PJ, Dodick DW, Leone M, Bardos JN, Oakes TM, Millen BA, Zhou C, Dowsett SA, Aurora SK, Ahn AH, et al: Trial of galcanezumab in prevention of episodic cluster headache. N Engl J Med. 381:132–141. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Reuter U, Goadsby PJ, Lanteri-Minet M, Wen S, Hours-Zesiger P, Ferrari MD and Klatt J: Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous preventive treatments were unsuccessful: A randomised, double-blind, placebo-controlled, phase 3b study. Lancet. 392:2280–2287. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Dodick DW, Lipton RB, Ailani J, Lu K, Finnegan M, Trugman JM and Szegedi A: Ubrogepant for the treatment of migraine. N Engl J Med. 381:2230–2241. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Lipton RB, Dodick DW, Ailani J, Lu K, Finnegan M, Szegedi A and Trugman JM: Effect of ubrogepant vs placebo on pain and the most bothersome associated symptom in the acute treatment of migraine: The ACHIEVE II randomized clinical trial. JAMA. 322:1887–1898. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Lipton RB, Croop R, Stock EG, Stock DA, Morris BA, Frost M, Dubowchik GM, Conway CM, Coric V and Goadsby PJ: Rimegepant, an oral calcitonin gene-related peptide receptor antagonist, for migraine. N Engl J Med. 381:142–149. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Croop R, Goadsby PJ, Stock DA, Conway CM, Forshaw M, Stock EG, Coric V and Lipton RB: Efficacy, safety, and tolerability of rimegepant orally disintegrating tablet for the acute treatment of migraine: A randomised, phase 3, double-blind, placebo-controlled trial. Lancet. 394:737–745. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Portenoy RK, Payne D and Jacobsen P: Breakthrough pain: Characteristics and impact in patients with cancer pain. Pain. 81:129–134. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Truscott BM: Carcinoma of the breast; an analysis of the symptoms, factors affecting prognosis, results of treatment and recurrences in 1211 cases treated at the middlesex hospital. Br J Cancer. 1:129–145. 1947. View Article : Google Scholar : PubMed/NCBI | |
|
Slagelse C, Munch T, Glazer C, Greene K, Finnerup NB, Kashani-Sabet M, Leong SP, Petersen KL and Rowbotham MC: Natural history of pain associated with melanoma surgery. Pain Rep. 3:e6892018. View Article : Google Scholar : PubMed/NCBI | |
|
Yeh CF, Li WY, Chu PY, Kao SY, Chen YW, Lee TL, Hsu YB, Yang CC and Tai SK: Pretreatment pain predicts perineural invasion in oral squamous cell carcinoma: A prospective study. Oral Oncol. 61:115–119. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Brain SD: Sensory neuropeptides: Their role in inflammation and wound healing. Immunopharmacology. 37:133–152. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Abdelaziz DM, Stone LS and Komarova SV: Localized experimental bone metastasis drives osteolysis and sensory hypersensitivity at distant non-tumor-bearing sites. Breast Cancer Res Treat. 153:9–20. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Auer J, Reeh PW and Fischer MJ: Acid-induced CGRP release from the stomach does not depend on TRPV1 or ASIC3. Neurogastroenterol Motil. 22:680–687. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Afroz S, Arakaki R, Iwasa T, Oshima M, Hosoki M, Inoue M, Baba O, Okayama Y and Matsuka Y: CGRP induces differential regulation of cytokines from satellite glial cells in trigeminal ganglia and orofacial nociception. Int J Mol Sci. 20:7112019. View Article : Google Scholar | |
|
Hansen RR, Vacca V, Pitcher T, Clark AK and Malcangio M: Role of extracellular calcitonin gene-related peptide in spinal cord mechanisms of cancer-induced bone pain. Pain. 157:666–676. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Niiyama Y, Kawamata T, Yamamoto J, Omote K and Namiki A: Bone cancer increases transient receptor potential vanilloid subfamily 1 expression within distinct subpopulations of dorsal root ganglion neurons. Neuroscience. 148:560–572. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Jimenez-Andrade JM, Bloom AP, Stake JI, Mantyh WG, Taylor RN, Freeman KT, Ghilardi JR, Kuskowski MA and Mantyh PW: Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain. J Neurosci. 30:14649–14656. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Bloom AP, Jimenez-Andrade JM, Taylor RN, Castañeda-Corral G, Kaczmarska MJ, Freeman KT, Coughlin KA, Ghilardi JR, Kuskowski MA and Mantyh PW: Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers. J Pain. 12:698–711. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wakabayashi H, Wakisaka S, Hiraga T, Hata K, Nishimura R, Tominaga M and Yoneda T: Decreased sensory nerve excitation and bone pain associated with mouse Lewis lung cancer in TRPV1-deficient mice. J Bone Miner Metab. 36:274–285. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Wacnik PW, Baker CM, Herron MJ, Kren BT, Blazar BR, Wilcox GL, Hordinsky MK, Beitz AJ and Ericson ME: Tumor-induced mechanical hyperalgesia involves CGRP receptors and altered innervation and vascularization of DsRed2 fluorescent hindpaw tumors. Pain. 115:95–106. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Nagamine K, Ozaki N, Shinoda M, Asai H, Nishiguchi H, Mitsudo K, Tohnai I, Ueda M and Sugiura Y: Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats. J Pain. 7:659–670. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Levy MJ, Classey JD, Maneesri S, Meeran K, Powell M and Goadsby PJ: The association between calcitonin gene-related peptide (CGRP), substance P and headache in pituitary tumours. Pituitary. 7:67–71. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Dottorini ME, Assi A, Sironi M, Sangalli G, Spreafico G and Colombo L: Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathologic variables. Cancer. 77:1556–1565. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Goadsby PJ, Edvinsson L and Ekman R: Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol. 23:193–196. 1988. View Article : Google Scholar : PubMed/NCBI | |
|
Kelley MJ, Snider RH, Becker KL and Johnson BE: Small cell lung carcinoma cell lines express mRNA for calcitonin and alpha- and beta-calcitonin gene related peptides. Cancer Lett. 81:19–25. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Takami H, Shikata J, Horie H, Horiuchi J, Sakurai H and Ito K: Radioimmunoassay of plasma calcitonin gene-related peptide (CGRP) levels in patients with endocrine tumor. Gan To Kagaku Ryoho. 16:2219–2225. 1989.PubMed/NCBI | |
|
Nagakawa O, Ogasawara M, Fujii H, Murakami K, Murata J, Fuse H and Saiki I: Effect of prostatic neuropeptides on invasion and migration of PC-3 prostate cancer cells. Cancer Lett. 133:27–33. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Nagakawa O, Ogasawara M, Murata J, Fuse H and Saiki I: Effect of prostatic neuropeptides on migration of prostate cancer cell lines. Int J Urol. 8:65–70. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Wimalawansa SJ: CGRP radioreceptor assay: A new diagnostic tool for medullary thyroid carcinoma. J Bone Miner Res. 8:467–473. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Angenendt L, Bormann E, Pabst C, Alla V, Görlich D, Braun L, Dohlich K, Schwöppe C, Bohlander SK, Arteaga MF, et al: The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia. Leukemia. 33:2830–2841. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Toda M, Suzuki T, Hosono K, Hayashi I, Hashiba S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, et al: Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc Natl Acad Sci USA. 105:13550–13555. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ostrovskaya A, Hick C, Hutchinson DS, Stringer BW, Wookey PJ, Wootten D, Sexton PM and Furness SGB: Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas. BMC Cancer. 19:1572019. View Article : Google Scholar : PubMed/NCBI | |
|
Dallmayer M, Li J, Ohmura S, Alba Rubio R, Baldauf MC, Hölting TLB, Musa J, Knott MML, Stein S, Cidre-Aranaz F, et al: Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma. Cell Death Dis. 10:1162019. View Article : Google Scholar : PubMed/NCBI | |
|
Höppener JW, Steenbergh PH, Slebos RJ, Visser A, Lips CJ, Jansz HS, Bechet JM, Lenoir GM, Born W, Haller-Brem S, et al: Expression of the second calcitonin/calcitonin gene-related peptide gene in Ewing sarcoma cell lines. J Clin Endocrinol Metab. 64:809–817. 1987. View Article : Google Scholar : PubMed/NCBI | |
|
Gutierrez S and Boada MD: Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+). Cancer Cell Int. 18:2162018. View Article : Google Scholar : PubMed/NCBI | |
|
Fristad I, Vandevska-Radunovic V, Fjeld K, Wimalawansa SJ and Hals Kvinnsland I: NK1, NK2, NK3 and CGRP1 receptors identified in rat oral soft tissues, and in bone and dental hard tissue cells. Cell Tissue Res. 311:383–391. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Warburg O: On the origin of cancer cells. Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI | |
|
Sasahira T and Kirita T: Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcinoma. Int J Mol Sci. 19:24132018. View Article : Google Scholar | |
|
Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H and Kirita T: The multifarious functions of pyruvate kinase M2 in oral cancer cells. Int J Mol Sci. 19:29072018. View Article : Google Scholar | |
|
Lu H, Li X, Luo Z, Liu J and Fan Z: Cetuximab reverses the Warburg effect by inhibiting HIF-1-regulated LDH-A. Mol Cancer Ther. 12:2187–2199. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhai X, Yang Y, Wan J, Zhu R and Wu Y: Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells. Oncol Rep. 30:2983–2991. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Rossetti L, Farrace S, Choi SB, Giaccari A, Sloan L, Frontoni S and Katz MS: Multiple metabolic effects of CGRP in conscious rats: Role of glycogen synthase and phosphorylase. Am J Physiol. 264:E1–E10. 1993.PubMed/NCBI | |
|
Tang W and Fan Y: SIRT6 as a potential target for treating insulin resistance. Life Sci. 231:1165582019. View Article : Google Scholar : PubMed/NCBI | |
|
Danaher RN, Loomes KM, Leonard BL, Whiting L, Hay DL, Xu LY, Kraegen EW, Phillips AR and Cooper GJ: Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization. Endocrinology. 149:154–160. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Faubert B, Vincent EE, Poffenberger MC and Jones RG: The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator. Cancer Lett. 356:165–170. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zelissen PM, Koppeschaar HP, Lips CJ and Hackeng WH: Calcitonin gene-related peptide in human obesity. Peptides. 12:861–863. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Gram DX, Hansen AJ, Wilken M, Elm T, Svendsen O, Carr RD, Ahrén B and Brand CL: Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats. Eur J Endocrinol. 153:963–969. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Jan CI, Tsai MH, Chiu CF, Huang YP, Liu CJ and Chang NW: Fenofibrate suppresses oral tumorigenesis via reprogramming metabolic processes: Potential drug repurposing for oral cancer. Int J Biol Sci. 12:786–798. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Hu Q, Peng J, Chen X, Li H, Song M, Cheng B and Wu T: Obesity and genes related to lipid metabolism predict poor survival in oral squamous cell carcinoma. Oral Oncol. 89:14–22. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Eichel K, Jullié D and von Zastrow M: β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation. Nat Cell Biol. 18:303–310. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Calebiro D, Nikolaev VO, Gagliani MC, de Filippis T, Dees C, Tacchetti C, Persani L and Lohse MJ: Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biol. 7:e10001722009. View Article : Google Scholar : PubMed/NCBI | |
|
Kuwasako K, Shimekake Y, Masuda M, Nakahara K, Yoshida T, Kitaura M, Kitamura K, Eto T and Sakata T: Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling. J Biol Chem. 275:29602–29609. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Yarwood RE, Imlach WL, Lieu T, Veldhuis NA, Jensen DD, Klein Herenbrink C, Aurelio L, Cai Z, Christie MJ, Poole DP, et al: Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission. Proc Natl Acad Sci USA. 114:12309–12314. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Mantyh PW, DeMaster E, Malhotra A, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE, et al: Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science. 268:1629–1632. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Steinhoff MS, von Mentzer B, Geppetti P, Pothoulakis C and Bunnett NW: Tachykinins and their receptors: Contributions to physiological control and the mechanisms of disease. Physiol Rev. 94:265–301. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Godbole A, Lyga S, Lohse MJ and Calebiro D: Publisher correction: Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription. Nat Commun. 9:54592018. View Article : Google Scholar : PubMed/NCBI | |
|
Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Steinman L: Elaborate interactions between the immune and nervous systems. Nat Immunol. 5:575–581. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Sternberg EM: Neural regulation of innate immunity: A coordinated nonspecific host response to pathogens. Nat Rev Immunol. 6:318–328. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Antúnez C, Torres MJ, López S, Rodriguez-Pena R, Blanca M, Mayorga C and Santamaría-Babi LF: Calcitonin gene-related peptide modulates interleukin-13 in circulating cutaneous lymphocyte-associated antigen-positive T cells in patients with atopic dermatitis. Br J Dermatol. 161:547–553. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Xing L, Guo J and Wang X: Induction and expression of beta-calcitonin gene-related peptide in rat T lymphocytes and its significance. J Immunol. 165:4359–4366. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Bracci-Laudiero L, Aloe L, Buanne P, Finn A, Stenfors C, Vigneti E, Theodorsson E and Lundeberg T: NGF modulates CGRP synthesis in human B-lymphocytes: A possible anti-inflammatory action of NGF? J Neuroimmunol. 123:58–65. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Bracci-Laudiero L, Aloe L, Caroleo MC, Buanne P, Costa N, Starace G and Lundeberg T: Endogenous NGF regulates CGRP expression in human monocytes, and affects HLA-DR and CD86 expression and IL-10 production. Blood. 106:3507–3514. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Ding W, Stohl LL, Wagner JA and Granstein RD: Calcitonin gene-related peptide biases Langerhans cells toward Th2-type immunity. J Immunol. 181:6020–6026. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Harzenetter MD, Novotny AR, Gais P, Molina CA, Altmayr F and Holzmann B: Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER. J Immunol. 179:607–615. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Wang F, Millet I, Bottomly K and Vignery A: Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes. J Biol Chem. 267:21052–21057. 1992.PubMed/NCBI | |
|
Kawamura N, Tamura H, Obana S, Wenner M, Ishikawa T, Nakata A and Yamamoto H: Differential effects of neuropeptides on cytokine production by mouse helper T cell subsets. Neuroimmunomodulation. 5:9–15. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A and Granstein RD: Regulation of langerhans cell function by nerves containing calcitonin gene-related peptide. Nature. 363:159–163. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Carucci JA, Ignatius R, Wei Y, Cypess AM, Schaer DA, Pope M, Steinman RM and Mojsov S: Calcitonin gene-related peptide decreases expression of HLA-DR and CD86 by human dendritic cells and dampens dendritic cell-driven T cell-proliferative responses via the type I calcitonin gene-related peptide receptor. J Immunol. 164:3494–3499. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Holzmann B: Modulation of immune responses by the neuropeptide CGRP. Amino Acids. 45:1–7. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Nguyen MQ, Wu Y, Bonilla LS, von Buchholtz LJ and Ryba NJP: Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing. PLoS One. 12:e01855432017. View Article : Google Scholar : PubMed/NCBI | |
|
Zeisel A, Hochgerner H, Lönnerberg P, Johnsson A, Memic F, vander Zwan J, Häring M, Braun E, Borm LE, La Manno G, et al: Molecular architecture of the mouse nervous system. Cell. 174:999–1014 e22. 2018. View Article : Google Scholar : PubMed/NCBI |
