Open Access

Diabetes and PKM2 affect prognosis in patients with intrahepatic cholangiocarcinoma

  • Authors:
    • Kui Fu
    • Xiaoli Yang
    • Hao Wu
    • Jianping Gong
    • Xiuyun Li
  • View Affiliations

  • Published online on: September 21, 2020     https://doi.org/10.3892/ol.2020.12128
  • Article Number: 265
  • Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diabetes mellitus (DM) is a common disease, but its effect on the prognosis of patients with intrahepatic cholangiocarcinoma (ICC) has not been reported. The aim of the present study was to explore the prognostic significance of diabetes in patients with ICC treated with hepatectomy and to clarify the role of pyruvate kinase M2 (PKM2). A consecutive retrospective cohort of 110 patients with ICC (28 with DM and 82 without DM) who underwent therapeutic hepatectomy was evaluated between January 2006 and January 2011. The clinicopathological characteristics of the two groups and the differences between overall survival (OS) and recurrence‑free survival (RFS) were analyzed. The Cox proportional hazards model was further used to identify independent prognostic predictors. PKM2 expression was measured using immunohistochemical staining in tissues collected, after obtaining informed consent. Patients with ICC with DM exhibited significantly lower OS and RFS rates at 1, 3 and 5 years compared with patients with ICC without DM. Cox multivariate analysis revealed that DM was an independent predictor of poor OS and RFS. Additionally, high PKM2 expression was significantly higher in patients with ICC with DM compared with that in patients without DM. Overall, DM was associated with significantly lower OS and RFS rates in patients with ICC. The underlying biological rationale may be attributed to the higher PKM2 expression rate.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fu K, Yang X, Wu H, Gong J and Li X: Diabetes and PKM2 affect prognosis in patients with intrahepatic cholangiocarcinoma. Oncol Lett 20: 265, 2020
APA
Fu, K., Yang, X., Wu, H., Gong, J., & Li, X. (2020). Diabetes and PKM2 affect prognosis in patients with intrahepatic cholangiocarcinoma. Oncology Letters, 20, 265. https://doi.org/10.3892/ol.2020.12128
MLA
Fu, K., Yang, X., Wu, H., Gong, J., Li, X."Diabetes and PKM2 affect prognosis in patients with intrahepatic cholangiocarcinoma". Oncology Letters 20.5 (2020): 265.
Chicago
Fu, K., Yang, X., Wu, H., Gong, J., Li, X."Diabetes and PKM2 affect prognosis in patients with intrahepatic cholangiocarcinoma". Oncology Letters 20, no. 5 (2020): 265. https://doi.org/10.3892/ol.2020.12128