Open Access

Identification of biomarkers predicting the chemotherapeutic outcomes of capecitabine and oxaliplatin in patients with gastric cancer

  • Authors:
    • Yan Zhang
    • Zhen Yuan
    • Renbin Shen
    • Yannan Jiang
    • Wei Xu
    • Menghui Gu
    • Xinhua Gu
  • View Affiliations

  • Published online on: September 24, 2020     https://doi.org/10.3892/ol.2020.12153
  • Article Number: 290
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The capecitabine and oxaliplatin (CapeOX) regimen is a commonly used adjuvant chemotherapeutic regimen for gastric cancer (GC). However, some patients exhibit a poor chemotherapy response due to genetic differences among individuals. Therefore, finding an effective sensitization strategy for CapeOX is important in the treatment of GC. The present study aimed to investigate the predictive biomarkers of the CapeOX chemotherapeutic outcomes for patients with GC. A total of 30 differentially expressed genes (DEGs) were identified using the gene expression profiles from The Cancer Genome Atlas capecitabine and oxaliplatin treatment GC cases and seven key DEGs [uroplakin‑1b (UPK1B), fatty acid‑binding protein, heart (FABP3), cystatin‑M, caspase‑5 (CASP5), corticosteroid 11‑β‑dehydrogenase isozyme 2, cytochrome P450 4X1 (CYP4X1) and epidermal growth factor receptor kinase substrate 8‑like protein 3] were associated with survival. Gene validation was performed in clinical samples divided into recurrence and nonrecurrence groups. Patients with high or low expression of UPK1B, FABP3, CASP5 and CYP4X1 had markedly different overall survival rates. A model was established and the area under the curve of the receiver operating characteristic reached 0.875 (0.793‑0.957), indicating that the model had good sensitivity and specificity.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
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Spandidos Publications style
Zhang Y, Yuan Z, Shen R, Jiang Y, Xu W, Gu M and Gu X: Identification of biomarkers predicting the chemotherapeutic outcomes of capecitabine and oxaliplatin in patients with gastric cancer. Oncol Lett 20: 290, 2020
APA
Zhang, Y., Yuan, Z., Shen, R., Jiang, Y., Xu, W., Gu, M., & Gu, X. (2020). Identification of biomarkers predicting the chemotherapeutic outcomes of capecitabine and oxaliplatin in patients with gastric cancer. Oncology Letters, 20, 290. https://doi.org/10.3892/ol.2020.12153
MLA
Zhang, Y., Yuan, Z., Shen, R., Jiang, Y., Xu, W., Gu, M., Gu, X."Identification of biomarkers predicting the chemotherapeutic outcomes of capecitabine and oxaliplatin in patients with gastric cancer". Oncology Letters 20.6 (2020): 290.
Chicago
Zhang, Y., Yuan, Z., Shen, R., Jiang, Y., Xu, W., Gu, M., Gu, X."Identification of biomarkers predicting the chemotherapeutic outcomes of capecitabine and oxaliplatin in patients with gastric cancer". Oncology Letters 20, no. 6 (2020): 290. https://doi.org/10.3892/ol.2020.12153