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Article Open Access

Endothelial transdifferentiation of human HGC‑27 gastric cancer cells in vitro

  • Authors:
    • Changxin Chen
    • Zhixin Hunag
    • Mucheng Wang
    • Zicheng Huang
    • Xiangbo Chen
    • Anye Huang
    • Binbin Zheng
    • Lishan Wu
    • Yi Liu
    • Xinwen Wang
    • Weifeng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350005, P.R. China, Department of Orthopaedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, P.R. China, Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan 450008, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 303
    |
    Published online on: September 29, 2020
       https://doi.org/10.3892/ol.2020.12166
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Abstract

Malignant tumor cells are able to transdifferentiate into other cell types in various tissues or organs. Recent studies have demonstrated the ability of cancer cells to transdifferentiate into functional endothelial cells (ECs). However, whether human gastric cancer (GC) cells are able to transdifferentiate into other cell types has remained largely elusive. Furthermore, whether HGC‑27 cells are able to participate in GC angiogenesis remains to be clarified. In the present study, the HGC‑27 cell line grown under hypoxic conditions for 4 days exhibited the typical ‘flagstone’ appearance, which is typical for cultured ECs. HGC‑27 cells cultured on Matrigel under hypoxic conditions gradually formed net‑like structures. Furthermore, the cultured HGC‑27 cells expressed CD31, CD34 and von Willebrand factor, the molecular markers for ECs, under hypoxic conditions. These results indicated that HGC‑27 cells, cultured under hypoxic conditions, are able to transdifferentiate into EC‑like cells in vitro.
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Copy and paste a formatted citation
Spandidos Publications style
Chen C, Hunag Z, Wang M, Huang Z, Chen X, Huang A, Zheng B, Wu L, Liu Y, Wang X, Wang X, et al: Endothelial transdifferentiation of human HGC‑27 gastric cancer cells <em>in&nbsp;vitro</em>. Oncol Lett 20: 303, 2020.
APA
Chen, C., Hunag, Z., Wang, M., Huang, Z., Chen, X., Huang, A. ... Xu, W. (2020). Endothelial transdifferentiation of human HGC‑27 gastric cancer cells <em>in&nbsp;vitro</em>. Oncology Letters, 20, 303. https://doi.org/10.3892/ol.2020.12166
MLA
Chen, C., Hunag, Z., Wang, M., Huang, Z., Chen, X., Huang, A., Zheng, B., Wu, L., Liu, Y., Wang, X., Xu, W."Endothelial transdifferentiation of human HGC‑27 gastric cancer cells <em>in&nbsp;vitro</em>". Oncology Letters 20.6 (2020): 303.
Chicago
Chen, C., Hunag, Z., Wang, M., Huang, Z., Chen, X., Huang, A., Zheng, B., Wu, L., Liu, Y., Wang, X., Xu, W."Endothelial transdifferentiation of human HGC‑27 gastric cancer cells <em>in&nbsp;vitro</em>". Oncology Letters 20, no. 6 (2020): 303. https://doi.org/10.3892/ol.2020.12166
Copy and paste a formatted citation
x
Spandidos Publications style
Chen C, Hunag Z, Wang M, Huang Z, Chen X, Huang A, Zheng B, Wu L, Liu Y, Wang X, Wang X, et al: Endothelial transdifferentiation of human HGC‑27 gastric cancer cells <em>in&nbsp;vitro</em>. Oncol Lett 20: 303, 2020.
APA
Chen, C., Hunag, Z., Wang, M., Huang, Z., Chen, X., Huang, A. ... Xu, W. (2020). Endothelial transdifferentiation of human HGC‑27 gastric cancer cells <em>in&nbsp;vitro</em>. Oncology Letters, 20, 303. https://doi.org/10.3892/ol.2020.12166
MLA
Chen, C., Hunag, Z., Wang, M., Huang, Z., Chen, X., Huang, A., Zheng, B., Wu, L., Liu, Y., Wang, X., Xu, W."Endothelial transdifferentiation of human HGC‑27 gastric cancer cells <em>in&nbsp;vitro</em>". Oncology Letters 20.6 (2020): 303.
Chicago
Chen, C., Hunag, Z., Wang, M., Huang, Z., Chen, X., Huang, A., Zheng, B., Wu, L., Liu, Y., Wang, X., Xu, W."Endothelial transdifferentiation of human HGC‑27 gastric cancer cells <em>in&nbsp;vitro</em>". Oncology Letters 20, no. 6 (2020): 303. https://doi.org/10.3892/ol.2020.12166
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