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The efficacy of chemotherapeutic drug combinations may be predicted by concordance of gene response to the single agents

  • Authors:
    • Andrew M. Gravett
    • Jayne L. Dennis
    • Angus G. Dalgleish
    • John Copier
    • Wai M. Liu
  • View Affiliations / Copyright

    Affiliations: Institute for Infection and Immunity, Department of Oncology, St. George's, University of London, London SW17 0RE, UK
    Copyright: © Gravett et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 321
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    Published online on: October 1, 2020
       https://doi.org/10.3892/ol.2020.12184
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Abstract

Determining the expression of genes in response to different classes of chemotherapeutic drugs may allow for a better understanding as to which may be used effectively in combination. In the present study, the human colorectal cancer cell line HCT116 was cultured with equi‑active concentrations of a series of anti‑cancer agents. Gene expression profiles were then measured by whole‑genome microarray. Although each drug induced a unique signature of gene expression in tumour cells, there were marked similarities between certain drugs, even in those from different classes. For example, the antimalarial agent artesunate and the platinum‑containing alkylating agent, oxaliplatin, produced a very similar mRNA expression pattern in HCT116 cells with ~14,000 genes being affected by the two drugs in the same way. Furthermore, the overall correlation of gene responses between two agents could predict whether their use in combination would lead to a greater or lesser effect on cell number, determined experimentally, than predicted by single agent experiments. The results indicated that even when working through different mechanisms, combining drugs that initiate a similar transcriptional response may constitute the best option for determining drug‑combination strategies for the treatment of cancer.
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1 

O'Connell MJ: Current status of adjuvant therapy for colorectal cancer. Oncology (Williston Park). 18:751–755; discussion 755–758. 2004.PubMed/NCBI

2 

Almendro V, Ametller E, García-Recio S, Collazo O, Casas I, Augé JM, Maurel J and Gascón P: The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin. PLoS One. 4:e47282009. View Article : Google Scholar : PubMed/NCBI

3 

Yardley DA: Drug resistance and the role of combination chemotherapy in improving patient outcomes. Int J Breast Cancer. 2013:1374142013. View Article : Google Scholar : PubMed/NCBI

4 

Buchbinder EI and Desai A: CTLA-4 and PD-1 pathways: Similarities, differences, and implications of their inhibition. Am J Clin Oncol. 39:98–106. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Gravett AM, Dalgleish AG and Copier J: In vitro culture with gemcitabine augments death receptor and NKG2D ligand expression on tumour cells. Sci Rep. 9:15442019. View Article : Google Scholar : PubMed/NCBI

6 

Scott KA, Dalgleish AG and Liu WM: The combination of cannabidiol and Δ9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model. Mol Cancer Ther. 13:2955–2967. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Gravett AM, Trautwein N, Stevanović S, Dalgleish AG and Copier J: Gemcitabine alters the proteasome composition and immunopeptidome of tumour cells. Oncoimmunology. 7:e14381072018. View Article : Google Scholar : PubMed/NCBI

8 

Nars MS and Kaneno R: Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy. Int J Cancer. 132:2471–2478. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Tsimberidou AM, Eggermont AM and Schilsky RL: Precision cancer medicine: The future is now, only better. Am Soc Clin Oncol Educ Book. 2014:61–69. 2014. View Article : Google Scholar

10 

Hu HM, Zhao X, Kaushik S, Robillard L, Barthelet A, Lin KK, Shah KN, Simmons AD, Raponi M, Harding TC and Bandyopadhyay S: A quantitative chemotherapy genetic interaction map reveals factors associated with PARP inhibitor resistance. Cell Rep. 23:918–929. 2018. View Article : Google Scholar : PubMed/NCBI

11 

McKenna MT, Weis JA, Brock A, Quaranta V and Yankeelov TE: Precision medicine with imprecise therapy: Computational modeling for chemotherapy in breast cancer. Transl Oncol. 11:732–742. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Deng X and Nakamura Y: Cancer precision medicine: From cancer screening to drug selection and personalized immunotherapy. Trends Pharmacol Sci. 38:15–24. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Pan B and Lentzsch S: The application and biology of immunomodulatory drugs (IMiDs) in cancer. Pharmacol Ther. 136:56–68. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Hideshima T, Chauhan D, Shima Y, Raje N, Davies FE, Tai YT, Treon SP, Lin B, Schlossman RL, Richardson P, et al: Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood. 96:2943–2950. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Liu WM, Gravett AM and Dalgleish AG: The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies. Int J Cancer. 128:1471–1480. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Gravett AM, Liu WM, Krishna S, Chan WC, Haynes RK, Wilson NL and Dalgleish AG: In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents. Cancer Chemother Pharmacol. 67:569–577. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Hamacher-Brady A, Stein HA, Turschner S, Toegel I, Mora R, Jennewein N, Efferth T, Eils R and Brady NR: Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J Biol Chem. 286:6587–6601. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Yang ND, Tan SH, Ng S, Shi Y, Zhou J, Tan KS, Wong WS and Shen HM: Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem. 289:33425–33441. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

20 

The Gene Ontology Consortium: The gene ontology resource: 20 Years and still GOing strong. Nucleic Acids Res. 47:D330–D338. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Mi H, Huang X, Muruganujan A, Tang H, Mills C, Kang D and Thomas PD: PANTHER version 11: Expanded annotation data from gene ontology and reactome pathways, and data analysis tool enhancements. Nucleic Acids Res. 45:D183–D189. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Scott KA, Dalgleish AG and Liu WM: Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration. Int J Oncol. 51:369–377. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Wallqvist A, Rabow AA, Shoemaker RH, Sausville EA and Covell DG: Establishing connections between microarray expression data and chemotherapeutic cancer pharmacology. Mol Cancer Ther. 1:311–320. 2002.PubMed/NCBI

24 

Tseng AH, Chung FH, Lee HC, Wu LC, Chen CH and Su LJ: Microarray analysis and establishment of drug screening platform using 5-fluorouracil resistance HCT116 colon cancer cells. Genomic Med Biomarkers Health Sci. 4:21–27. 2012. View Article : Google Scholar

25 

Lønning PE, Sørlie T, Perou CM, Brown PO, Botstein D and Børresen-Dale AL: Microarrays in primary breast cancer-lessons from chemotherapy studies. Endocr Relat Cancer. 8:259–263. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Kao KJ, Chang KM, Hsu HC and Huang AT: Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: Implications for treatment optimization. BMC Cancer. 11:1432011. View Article : Google Scholar : PubMed/NCBI

27 

Kamel HF and Al-Amodi HS: Exploitation of gene expression and cancer biomarkers in paving the path to era of personalized medicine. Genomics Proteomics Bioinformatics. 15:220–235. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Wang TH and Chao A: Microarray analysis of gene expression of cancer to guide the use of chemotherapeutics. Taiwan J Obstet Gynecol. 46:222–229. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Pritchard JR, Bruno PM, Gilbert LA, Capron KL, Lauffenburger DA and Hemann MT: Defining principles of combination drug mechanisms of action. Proc Natl Acad Sci USA. 110:E170–E179. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Liu WM, Scott KA, Dennis JL, Kaminska E, Levett AJ and Dalgleish AG: Naltrexone at low doses upregulates a unique gene expression not seen with normal doses: Implications for its use in cancer therapy. Int J Oncol. 49:793–802. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Fink EC and Ebert BL: The novel mechanism of lenalidomide activity. Blood. 126:2366–2369. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Jackson SP and Bartek J: The DNA-damage response in human biology and disease. Nature. 461:1071–1078. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Liu WM: Enhancing the cytotoxic activity of novel targeted therapies-is there a role for a combinatorial approach? Curr Clin Pharmacol. 3:108–117. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Housman G, Byler S, Heerboth S, Lapinska K, Longacre M, Snyder N and Sarkar S: Drug resistance in cancer: An overview. Cancers (Basel). 6:1769–1792. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Rixe O, Ortuzar W, Alvarez M, Parker R, Reed E, Paull K and Fojo T: Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the national cancer institute's anticancer drug screen panel. Biochem Pharmacol. 52:1855–1865. 1996. View Article : Google Scholar : PubMed/NCBI

36 

Shah MA and Schwartz GK: The relevance of drug sequence in combination chemotherapy. Drug Resist Updat. 3:335–356. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gravett AM, Dennis JL, Dalgleish AG, Copier J and Liu WM: The efficacy of chemotherapeutic drug combinations may be predicted by concordance of gene response to the single agents. Oncol Lett 20: 321, 2020.
APA
Gravett, A.M., Dennis, J.L., Dalgleish, A.G., Copier, J., & Liu, W.M. (2020). The efficacy of chemotherapeutic drug combinations may be predicted by concordance of gene response to the single agents. Oncology Letters, 20, 321. https://doi.org/10.3892/ol.2020.12184
MLA
Gravett, A. M., Dennis, J. L., Dalgleish, A. G., Copier, J., Liu, W. M."The efficacy of chemotherapeutic drug combinations may be predicted by concordance of gene response to the single agents". Oncology Letters 20.6 (2020): 321.
Chicago
Gravett, A. M., Dennis, J. L., Dalgleish, A. G., Copier, J., Liu, W. M."The efficacy of chemotherapeutic drug combinations may be predicted by concordance of gene response to the single agents". Oncology Letters 20, no. 6 (2020): 321. https://doi.org/10.3892/ol.2020.12184
Copy and paste a formatted citation
x
Spandidos Publications style
Gravett AM, Dennis JL, Dalgleish AG, Copier J and Liu WM: The efficacy of chemotherapeutic drug combinations may be predicted by concordance of gene response to the single agents. Oncol Lett 20: 321, 2020.
APA
Gravett, A.M., Dennis, J.L., Dalgleish, A.G., Copier, J., & Liu, W.M. (2020). The efficacy of chemotherapeutic drug combinations may be predicted by concordance of gene response to the single agents. Oncology Letters, 20, 321. https://doi.org/10.3892/ol.2020.12184
MLA
Gravett, A. M., Dennis, J. L., Dalgleish, A. G., Copier, J., Liu, W. M."The efficacy of chemotherapeutic drug combinations may be predicted by concordance of gene response to the single agents". Oncology Letters 20.6 (2020): 321.
Chicago
Gravett, A. M., Dennis, J. L., Dalgleish, A. G., Copier, J., Liu, W. M."The efficacy of chemotherapeutic drug combinations may be predicted by concordance of gene response to the single agents". Oncology Letters 20, no. 6 (2020): 321. https://doi.org/10.3892/ol.2020.12184
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