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A gut butyrate‑producing bacterium Butyricicoccus pullicaecorum regulates short‑chain fatty acid transporter and receptor to reduce the progression of 1,2‑dimethylhydrazine‑associated colorectal cancer

  • Authors:
    • Shih-Chang Chang
    • Ming-Hung Shen
    • Chih-Yi Liu
    • Chi-Ming  Pu
    • Je-Ming Hu
    • Chi-Jung Huang
  • View Affiliations / Copyright

    Affiliations: Division of Colorectal Surgery, Department of Surgery, Cathay General Hospital, Taipei 10630, Taiwan, R.O.C., Department of Surgery, Fu Jen Catholic University Hospital, New Taipei City 24352, Taiwan, R.O.C., Department of Pathology, Sijhih Cathay General Hospital, New Taipei City 22174, Taiwan, R.O.C., Division of Plastic Surgery, Cathay General Hospital, Taipei 10630, Taiwan, R.O.C., Division of Colorectal Surgery, Department of Surgery, Tri‑Service General Hospital, Taipei 11490, Taiwan, R.O.C., School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan, R.O.C.
    Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 327
    |
    Published online on: October 5, 2020
       https://doi.org/10.3892/ol.2020.12190
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Abstract

Gut microbes influence tumor development and progression in the intestines and may provide a novel paradigm for the treatment of colorectal cancer (CRC). Gut dysbiosis may be associated with the development and progression of CRC. Identifying the interactions between the colonic tract and gut microbiota may provide novel information relevant to CRC prevention. The present study examined the effects of butyrate‑producing Butyricicoccus pullicaecorum (B. pullicaecorum) on mice with 1,2‑dimethylhydrazine (DMH)‑induced CRC and the microbial metabolite of B. pullicaecorum on CRC cells. Immunohistochemical staining of the mouse colon tissues and reverse transcription PCR of CRC cells were used to determine the protein and mRNA expression levels of the short‑chain fatty acid (SCFA) transporter solute carrier family 5 member 8 (SLC5A8) and G‑protein‑coupled receptor 43 (GPR43). In CRC‑bearing mice fed B. pullicaecorum, DMH‑induced CRC regressed, body weight increased and serum carcinoembryonic antigen levels decreased. Notably, SLC5A8 and GPR43 were diffusely and moderately to strongly expressed in the neoplastic epithelial cells and underlying muscularis propria in the colons of the mice. In conclusion, administration of B. pullicaecorum or its metabolites improved the clinical outcome of CRC by activating the SCFA transporter and/or receptor. These results indicated that B. pullicaecorum was a probiotic with anti‑CRC potential.
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Copy and paste a formatted citation
Spandidos Publications style
Chang S, Shen M, Liu C, Pu C, Hu J and Huang C: A gut butyrate‑producing bacterium <em>Butyricicoccus&nbsp;pullicaecorum</em> regulates short‑chain fatty acid transporter and receptor to reduce the progression of 1,2‑dimethylhydrazine‑associated colorectal cancer. Oncol Lett 20: 327, 2020.
APA
Chang, S., Shen, M., Liu, C., Pu, C., Hu, J., & Huang, C. (2020). A gut butyrate‑producing bacterium <em>Butyricicoccus&nbsp;pullicaecorum</em> regulates short‑chain fatty acid transporter and receptor to reduce the progression of 1,2‑dimethylhydrazine‑associated colorectal cancer. Oncology Letters, 20, 327. https://doi.org/10.3892/ol.2020.12190
MLA
Chang, S., Shen, M., Liu, C., Pu, C., Hu, J., Huang, C."A gut butyrate‑producing bacterium <em>Butyricicoccus&nbsp;pullicaecorum</em> regulates short‑chain fatty acid transporter and receptor to reduce the progression of 1,2‑dimethylhydrazine‑associated colorectal cancer". Oncology Letters 20.6 (2020): 327.
Chicago
Chang, S., Shen, M., Liu, C., Pu, C., Hu, J., Huang, C."A gut butyrate‑producing bacterium <em>Butyricicoccus&nbsp;pullicaecorum</em> regulates short‑chain fatty acid transporter and receptor to reduce the progression of 1,2‑dimethylhydrazine‑associated colorectal cancer". Oncology Letters 20, no. 6 (2020): 327. https://doi.org/10.3892/ol.2020.12190
Copy and paste a formatted citation
x
Spandidos Publications style
Chang S, Shen M, Liu C, Pu C, Hu J and Huang C: A gut butyrate‑producing bacterium <em>Butyricicoccus&nbsp;pullicaecorum</em> regulates short‑chain fatty acid transporter and receptor to reduce the progression of 1,2‑dimethylhydrazine‑associated colorectal cancer. Oncol Lett 20: 327, 2020.
APA
Chang, S., Shen, M., Liu, C., Pu, C., Hu, J., & Huang, C. (2020). A gut butyrate‑producing bacterium <em>Butyricicoccus&nbsp;pullicaecorum</em> regulates short‑chain fatty acid transporter and receptor to reduce the progression of 1,2‑dimethylhydrazine‑associated colorectal cancer. Oncology Letters, 20, 327. https://doi.org/10.3892/ol.2020.12190
MLA
Chang, S., Shen, M., Liu, C., Pu, C., Hu, J., Huang, C."A gut butyrate‑producing bacterium <em>Butyricicoccus&nbsp;pullicaecorum</em> regulates short‑chain fatty acid transporter and receptor to reduce the progression of 1,2‑dimethylhydrazine‑associated colorectal cancer". Oncology Letters 20.6 (2020): 327.
Chicago
Chang, S., Shen, M., Liu, C., Pu, C., Hu, J., Huang, C."A gut butyrate‑producing bacterium <em>Butyricicoccus&nbsp;pullicaecorum</em> regulates short‑chain fatty acid transporter and receptor to reduce the progression of 1,2‑dimethylhydrazine‑associated colorectal cancer". Oncology Letters 20, no. 6 (2020): 327. https://doi.org/10.3892/ol.2020.12190
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