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Neoadjuvant chemotherapy promotes the expression of HER3 in patients with ovarian cancer

  • Authors:
    • Takaaki Mizuno
    • Yuki Kojima
    • Kan Yonemori
    • Hiroshi Yoshida
    • Yukiko Sugiura
    • Yohei Ohtake
    • Hitomi S. Okuma
    • Tadaaki Nishikawa
    • Maki Tanioka
    • Kazuki Sudo
    • Akihiko Shimomura
    • Emi Noguchi
    • Tomoyasu Kato
    • Tatsunori Shimoi
    • Masaya Uno
    • Mitsuya Ishikawa
    • Yasuhiro Fujiwara
    • Yuichiro Ohe
    • Kenji Tamura
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo 104‑0045, Japan, Department of Pathology, National Cancer Center Hospital, Tokyo 104‑0045, Japan, Department of Gynecology, National Cancer Center Hospital, Tokyo 104‑0045, Japan, The Jikei University Graduate School of Medicine, Tokyo 105‑8461, Japan
    Copyright: © Mizuno et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 336
    |
    Published online on: October 7, 2020
       https://doi.org/10.3892/ol.2020.12200
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Abstract

HER3 (erbB3) signaling serves an important role in the development and chemoresistance of ovarian cancer, and is activated by chemotherapy. To evaluate the influence of neoadjuvant chemotherapy and other clinical factors on the expression of HER3, as well as to examine its role as a prognostic marker, the present study evaluated archived tissues from patients who underwent surgery for ovarian cancer between 2011 and 2018 at our hospital. Immunohistochemical staining for HER3 was performed using formalin‑fixed paraffin‑embedded surgical specimens and biopsy samples. In total, data from 111 patients with sufficient surgically resected tumor samples were extracted. A total of 28 patients with histology type high‑grade serous carcinoma (HGSC) had specimens available from both pre‑chemotherapy biopsies and post‑chemotherapy surgery. High HER3 expression (HER3‑high) was observed in 64 patients (58%), whereas low HER3 expression (HER3‑low) was observed in 47 patients (42%). Multivariate logistic regression analysis identified neoadjuvant chemotherapy [odds ratio (OR), 7.49; 95% confidence interval (CI), 2.48‑22.64; P<0.001) and non‑HGSC histology (OR, 5.42; 95% CI, 1.99‑14.78; P<0.001) as significant predictive factors for HER3‑high. In pre‑chemotherapy biopsy specimens, 15 patients were HER3‑high and 13 were HER3‑low. After chemotherapy, eight of 13 patients with HER3‑low exhibited a change in status to HER3‑high, with a trend toward poorer progression‑free survival compared to that of patients whose status remained HER3‑low. In conclusion, HER3 overexpression was revealed to be common among patients with ovarian cancer, especially in those with non‑HGSC histology. In addition, HER3 expression may be promoted by chemotherapy. These findings suggested that patients with ovarian cancer are good candidates for emerging HER3‑targeting therapies.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Cancer Registry and Statistics, . Cancer Statistics in Japan - 2018. Cancer Information Service NCC. (Japan). simplehttps://ganjoho.jp/en/professional/statistics/brochure/2018_en.htmlJune 26–2020

3 

Ozols RF, Bundy BN, Greer BE, Fowler JM, Clarke-Pearson D, Burger RA, Mannel RS, DeGeest K, Hartenbach EM and Baergen R; Gynecologic Oncology Group, : Phase III Trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: A Gynecologic Oncology Group Study. J Clin Oncol. 21:3194–3200. 2003. View Article : Google Scholar : PubMed/NCBI

4 

du Bois A, Lück HJ, Meier W, Adams HP, Möbus V, Costa S, Bauknecht T, Richter B, Warm M, Schröder W, et al: A randomized clinical trial of Cisplatin/paclitaxel versus Carboplatin/paclitaxel as First-line treatment of ovarian cancer. J Natl Cancer Inst. 95:1320–1329. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Tanner B, Hasenclever D, Stern K, Schormann W, Bezler M, Hermes M, Brulport M, Bauer A, Schiffer IB, Gebhard S, et al: ErbB-3 predicts survival in ovarian cancer. J Clin Oncol. 24:4317–4323. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Sheng Q, Liu X, Fleming E, Yuan K, Piao H, Chen J, Moustafa Z, Thomas RK, Greulich H, Schinzel A, et al: An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer Cell. 17:298–310. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Xue C, Liang F, Mahmood R, Vuolo M, Wyckoff J, Qian H, Tsai KL, Kim M, Locker J, Zhang ZY and Segall JE: ErbB3-dependent motility and intravasation in breast cancer metastasis. Cancer Res. 66:1418–1426. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Reschke M, Mihic-Probst D, van der Horst EH, Knyazev P, Wild PJ, Hutterer M, Meyer S, Dummer R, Moch H and Ullrich A: HER3 is a determinant for poor prognosis in melanoma. Clin Cancer Res. 14:5188–5197. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Ledel F, Hallstrom M, Ragnhammar P, Ohrling K and Edler D: HER3 expression in patients with primary colorectal cancer and corresponding lymph node metastases related to clinical outcome. Eur J Cancer. 50:656–662. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Li Q, Zhang R, Yan H, Zhao P, Wu L, Wang H, Li T and Cao B: Prognostic significance of HER3 in patients with malignant solid tumors. Oncotarget. 8:67140–67151. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Amin DN, Campbell MR and Moasser MM: The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics. Semin Cell Dev Biol. 21:944–950. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Baselga J and Swain SM: Novel anticancer targets: Revisiting ERBB2 and discovering ERBB3. Nat Rev Cancer. 9:463–475. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Simpson BJ, Weatherill J, Miller EP, Lessells AM, Langdon SP and Miller WR: c-erbB-3 protein expression in ovarian tumours. Br J Cancer. 71:758–762. 1995. View Article : Google Scholar : PubMed/NCBI

14 

Cirstea AE, Stepan AE, Margaritescu C, Zavoi RE, Olimid DA and Simionescu CE: The immunoexpression of EGFR, HER2 and HER3 in malignant serous ovarian tumors. Rom J Morphol Embyol. 58:1269–1273. 2017.

15 

Théret N, Musso O, Campion JP, Turlin B, Loréal O, L'Helgoualc'h A and Clément B: Overexpression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 in liver from patients with gastrointestinal adenocarcinoma and no detectable metastasis. Int J Cancer. 74:426–432. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Tanner B, Hengstler JG, Luch A, Meinert R, Kreutz E, Arand M, Wilkens C, Hofmann M, Oesch F, Knapstein PG and Becker R: C-myc mRNA expression in epithelial ovarian carcinomas in relation to estrogen receptor status, metastatic spread, survival time, FIGO stage, and histologic grade and type. Int J Gynecol Pathol. 17:66–74. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Hengstler JG, Pilch H, Schmidt M, Dahlenburg H, Sagemüller J, Schiffer I, Oesch F, Knapstein PG, Kaina B and Tanner B: Metallothionein expression in ovarian cancer in relation to histopathological parameters and molecular markers of prognosis. Int J Cancer. 95:121–127. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Bezler M, Hengstler JG and Ullrich A: Inhibition of doxorubicin-induced HER3-PI3K-AKT signalling enhances apoptosis of ovarian cancer cells. Mol Oncol. 6:516–529. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Bartley AN, Washington MK, Ventura CB, Ismaila N, Colasacco C, Benson AB III, Carrato A, Gulley ML, Jain D, Kakar S, et al: HER2 Testing and clinical decision making in gastroesophageal adenocarcinoma: Guideline from the college of american pathologists, american society for clinical pathology, and american society of clinical oncology. Arch Pathol Lab Med. 140:1345–1363. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Mishra R, Patel H, Alanazi S, Yuan L and Garrett JT: HER3 signaling and targeted therapy in cancer. Oncol Rev. 12:3552018.PubMed/NCBI

21 

Black LE, Longo JF and Carroll SL: Mechanisms of receptor Tyrosine-protein kinase ErbB-3 (ERBB3) action in human neoplasia. Am J Pathol. 189:1898–1912. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Liu JF, Ray-Coquard I, Selle F, Poveda AM, Cibula D, Hirte H, Hilpert F, Raspagliesi F, Gladieff L, Harter P, et al: Randomized phase II trial of seribantumab in combination with paclitaxel in patients with advanced platinum-resistant or -refractory ovarian cancer. J Clin Oncol. 34:4345–4353. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Kogawa T, Yonemori K, Masuda N, Takahashi S, Takahashi M, Iwase H, Nakayama T, Saeki T, Toyama T, Takano T, et al: Single agent activity of U3-1402, a HER3-targeting antibody-drug conjugate, in breast cancer patients: Phase 1 dose escalation study. J Clin Oncol. 36 (Suppl 15):S25122018. View Article : Google Scholar

24 

Janne PA, Yu HA, Johnson ML, Steuer CE, Vigliotti M, Iacobucci C, Chen S, Yu C and Sellami DB: Safety and preliminary antitumor activity of U3-1402: A HER3-targeted antibody drug conjugate in EGFR TKI-resistant, EGFRm NSCLC. J Clin Oncol. 37 (Suppl 15):S90102019. View Article : Google Scholar

25 

Mizuno M, Kikkawa F, Shibata K, Kajiyama H, Ino K, Kawai M, Nagasaka T and Nomura S: Long-term follow-up and prognostic factor analysis in clear cell adenocarcinoma of the ovary. J Surg Oncol. 94:138–143. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Crotzer DR, Sun CC, Coleman RL, Wolf JK, Levenback CF and Gershenson DM: Lack of effective systemic therapy for recurrent clear cell carcinoma of the ovary. Gynecol Oncol. 105:404–408. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Takano M, Sugiyama T, Yaegashi N, Sakuma M, Suzuki M, Saga Y, Kuzuya K, Kigawa J, Shimada M, Tsuda H, et al: Low response rate of second-line chemotherapy for recurrent or refractory clear cell carcinoma of the ovary: A retrospective Japan clear cell carcinoma study. Int J Gynecol Cancer. 18:937–942. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Cao Z, Wu X, Yen L, Sweeney C and Carraway KL III: Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Mol Cell Biol. 27:2180–2188. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Sak MM, Breen K, Ronning SB, Pedersen NM, Bertelsen V, Stang E and Madshus IH: The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner. Carcinogenesis. 33:1031–1039. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Ocana A, Vera-Badillo F, Seruga B, Templeton A, Pandiella A and Amir E: HER3 overexpression and survival in solid tumors: A meta-analysis. J Natl Cancer Inst. 105:266–273. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Tsuda H, Kurosumi M, Umemura S, Yamamoto S, Kobayashi T and Osamura RY: HER2 testing on core needle biopsy specimens from primary breast cancers: Interobserver reproducibility and concordance with surgically resected specimens. BMC Cancer. 10:5342010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mizuno T, Kojima Y, Yonemori K, Yoshida H, Sugiura Y, Ohtake Y, Okuma HS, Nishikawa T, Tanioka M, Sudo K, Sudo K, et al: Neoadjuvant chemotherapy promotes the expression of HER3 in patients with ovarian cancer. Oncol Lett 20: 336, 2020.
APA
Mizuno, T., Kojima, Y., Yonemori, K., Yoshida, H., Sugiura, Y., Ohtake, Y. ... Tamura, K. (2020). Neoadjuvant chemotherapy promotes the expression of HER3 in patients with ovarian cancer. Oncology Letters, 20, 336. https://doi.org/10.3892/ol.2020.12200
MLA
Mizuno, T., Kojima, Y., Yonemori, K., Yoshida, H., Sugiura, Y., Ohtake, Y., Okuma, H. S., Nishikawa, T., Tanioka, M., Sudo, K., Shimomura, A., Noguchi, E., Kato, T., Shimoi, T., Uno, M., Ishikawa, M., Fujiwara, Y., Ohe, Y., Tamura, K."Neoadjuvant chemotherapy promotes the expression of HER3 in patients with ovarian cancer". Oncology Letters 20.6 (2020): 336.
Chicago
Mizuno, T., Kojima, Y., Yonemori, K., Yoshida, H., Sugiura, Y., Ohtake, Y., Okuma, H. S., Nishikawa, T., Tanioka, M., Sudo, K., Shimomura, A., Noguchi, E., Kato, T., Shimoi, T., Uno, M., Ishikawa, M., Fujiwara, Y., Ohe, Y., Tamura, K."Neoadjuvant chemotherapy promotes the expression of HER3 in patients with ovarian cancer". Oncology Letters 20, no. 6 (2020): 336. https://doi.org/10.3892/ol.2020.12200
Copy and paste a formatted citation
x
Spandidos Publications style
Mizuno T, Kojima Y, Yonemori K, Yoshida H, Sugiura Y, Ohtake Y, Okuma HS, Nishikawa T, Tanioka M, Sudo K, Sudo K, et al: Neoadjuvant chemotherapy promotes the expression of HER3 in patients with ovarian cancer. Oncol Lett 20: 336, 2020.
APA
Mizuno, T., Kojima, Y., Yonemori, K., Yoshida, H., Sugiura, Y., Ohtake, Y. ... Tamura, K. (2020). Neoadjuvant chemotherapy promotes the expression of HER3 in patients with ovarian cancer. Oncology Letters, 20, 336. https://doi.org/10.3892/ol.2020.12200
MLA
Mizuno, T., Kojima, Y., Yonemori, K., Yoshida, H., Sugiura, Y., Ohtake, Y., Okuma, H. S., Nishikawa, T., Tanioka, M., Sudo, K., Shimomura, A., Noguchi, E., Kato, T., Shimoi, T., Uno, M., Ishikawa, M., Fujiwara, Y., Ohe, Y., Tamura, K."Neoadjuvant chemotherapy promotes the expression of HER3 in patients with ovarian cancer". Oncology Letters 20.6 (2020): 336.
Chicago
Mizuno, T., Kojima, Y., Yonemori, K., Yoshida, H., Sugiura, Y., Ohtake, Y., Okuma, H. S., Nishikawa, T., Tanioka, M., Sudo, K., Shimomura, A., Noguchi, E., Kato, T., Shimoi, T., Uno, M., Ishikawa, M., Fujiwara, Y., Ohe, Y., Tamura, K."Neoadjuvant chemotherapy promotes the expression of HER3 in patients with ovarian cancer". Oncology Letters 20, no. 6 (2020): 336. https://doi.org/10.3892/ol.2020.12200
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