Aberrantly upregulated FAM83H‑AS1 facilitates malignant progression of esophageal squamous cell carcinoma

Bu,Lijia; Wang,Rong; Liu,Pingping; Da,Jie

doi:10.3892/ol.2020.12231

Aberrantly upregulated FAM83H‑AS1 facilitates malignant progression of esophageal squamous cell carcinoma

Authors:
- Lijia Bu
- Rong Wang
- Pingping Liu
- Jie Da
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Affiliations: Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China
Published online on: October 19, 2020 https://doi.org/10.3892/ol.2020.12231
Article Number: 368

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Abstract

The biological roles of the newly identified long non‑coding RNA family with sequence similarity 83 member H antisense 1 (FAM83H‑AS1) in esophageal squamous cell carcinoma (ESCC) have remained largely elusive. In the present study, it was determined that, in comparison with paired para‑tumorous tissues or normal esophageal epithelial cells, FAM83H‑AS1 expression in cancer tissues and cell lines was markedly upregulated. Furthermore, FAM83H‑AS1 expression was significantly elevated in patients with ESCC and lymph node metastasis or a late TNM stage, while no association with any other clinicopathological characteristics was detected. Furthermore, the overall and disease‑free survival, as assessed by the Kaplan‑Meier method, were significantly shortened in patients with high FAM83H‑AS1 expression. A functional study then uncovered that knockdown of FAM83H‑AS1 significantly suppressed the proliferation and migration of ESCC cells. The present results suggested that FAM83H‑AS1 may facilitate the malignant progression of ESCC and may be utilized as a prognostic predictor and possibly a novel therapeutic target in ESCC that warrants further exploration.

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