Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells

  • Authors:
    • Yohei Kamikawa
    • Kento Yokota
    • Kosuke Oikawa
    • Fuyuki Sato
    • Yasuteru Muragaki
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Wakayama Medical University, Wakayama 641‑8509, Japan
  • Article Number: 369
    |
    Published online on: October 19, 2020
       https://doi.org/10.3892/ol.2020.12232
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Myxoid liposarcoma (MLS) is thought to occur due to defective adipocytic differentiation in mesenchymal stem cells. A promising strategy for MLS treatment is the prevention of sarcomagenesis by promoting the terminal differentiation of MLS cells into adipocytes. Previous studies have reported that the suppression of megakaryoblastic leukemia 1 (MKL1) expression induces adipocytic differentiation in preadipocyte cell lines. The present study aimed to investigate the effects of MKL1 suppression on MLS cells. In the present study, MKL1 knockdown was demonstrated to promote the adipocytic differentiation of an MLS‑derived cell line, designated 1955/91, under adipogenic conditions. This suggests that therapeutic targeting of the MKL1‑associated molecular pathway has potential as a promising method of MLS treatment. However, the induction of adipogenesis by MKL knockdown was incomplete, and Oil Red O staining indicated that intracellular lipid droplets were only sporadically generated. Conversely, MKL1 knockdown reduced the growth of the MLS cells. As adipocytic differentiation in vitro requires cellular confluence, the decreased growth rate of the MLS cells following MKL1 knockdown could be attributed to the incomplete induction of adipogenesis. Translocated in liposarcoma‑CCAAT/enhancer‑binding protein homologous protein (TLS‑CHOP) is an MLS‑specific oncoprotein that is thought to play key roles in sarcomagenesis and the suppression of adipocytic differentiation. However, the results of western blotting analyses suggest that TLS‑CHOP has limited effects on MKL1 expression in MLS cells and that MKL1 knockdown hardly affects TLS‑CHOP expression. Thus, it is postulated that the inhibitory effect of TLS‑CHOP on adipogenesis is not associated with MKL1 expression. However, MKL1 and the molecular pathway involving MKL1 appear to be attractive targets for the differentiation therapy of MLS.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

He BC, Chen L, Zuo GW, Zhang W, Bi Y, Huang J, Wang Y, Jiang W, Luo Q, Shi Q, et al: Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. Clin Cancer Res. 16:2235–2245. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Aubin JE: Regulation of osteoblast formation and function. Rev Endocr Metab Disord. 2:81–94. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Luu HH, Song WX, Luo X, Manning D, Luo J, Deng ZL, Sharff KA, Montag AG, Haydon RC and He TC: Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. J Orthop Res. 25:665–677. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Deng ZL, Sharff KA, Tang N, Song WX, Luo J, Luo X, Chen J, Bennett E, Reid R, Manning D, et al: Regulation of osteogenic differentiation during skeletal development. Front Biosci. 13:2001–2021. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer, and cancer stem cells. Nature. 414:105–111. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Luther G, Rames R, Wagner ER, Zhu G, Luo Q, Bi Y, Kim SH, Gao JL, Huang E, Yang K, et al: Molecular basis of differentiation therapy for soft tissue sarcomas. Trends Cancer Res. 6:69–90. 2010.PubMed/NCBI

7 

Fritchie KJ, Goldblum JR, Tubbs RR, Sun Y, Carver P, Billings SD and Rubin BP: The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: Implications for diagnosis on small biopsy specimens. Am J Clin Pathol. 137:229–239. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Dal Cin P, Sciot R, Panagopoulos I, Aman P, Samson I, Mandahl N, Mitelman F, Van den Berghe H and Fletcher CD: Additional evidence of a variant translocation t(12;22) with EWS-CHOP fusion in myxoid liposarcoma: Clinicopathologic features. J Pathol. 182:437–441. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Loubignac F, Bourtoul C and Chapel F: Myxoid liposarcoma: A rare soft tissue tumor with a misleading benign appearance. World J Surg Oncol. 7:422009. View Article : Google Scholar : PubMed/NCBI

10 

Forni C, Minuzzo M, Virdis E, Tamborini E, Simone M, Tavecchio M, Erba E, Grosso F, Gronchi A, Aman P, et al: Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. Mol Cancer Ther. 8:449–457. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Charytonowicz E, Terry M, Coakley K, Telis L, Remotti F, Cordon-Cardo C, Taub RN and Matushansky I: PPARγ agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma. J Clin Invest. 122:886–898. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Oikawa K, Mizusaki A, Takanashi M, Ozaki T, Sato F, Kuroda M and Muragaki Y: PRG4 expression in myxoid liposarcoma maintains tumor cell growth through suppression of an antitumor cytokine IL-24. Biochem Biophys Res Commun. 485:209–214. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Gomez EW, Chen QK, Gjorevski N and Nelson CM: Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J Cell Biochem. 110:44–51. 2010.PubMed/NCBI

14 

Connelly JT, Gautrot JE, Trappmann B, Tan DW, Donati G, Huck WT and Watt FM: Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol. 12:711–718. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Selvaraj A and Prywes R: Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. J Biol Chem. 278:41977–41987. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Esnault C, Stewart A, Gualdrini F, East P, Horswell S, Matthews N and Treisman R: Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts. Genes Dev. 28:943–958. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Kalita K, Kharebava G, Zheng JJ and Hetman M: Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity. J Neurosci. 26:10020–10032. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Kalita K, Kuzniewska B and Kaczmarek L: MKLs: Co-factors of serum response factor (SRF) in neuronal responses. Int J Biochem Cell Biol. 44:1444–1447. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Nobusue H, Onishi N, Shimizu T, Sugihara E, Oki Y, Sumikawa Y, Chiyoda T, Akashi K, Saya H and Kano K: Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation. Nat commun. 5:33682014. View Article : Google Scholar : PubMed/NCBI

20 

Rosenwald M, Efthymiou V, Opitz L and Wolfrum C: SRF and MKL1 independently inhibit brown adipogenesis. PLoS One. 12:e01706432017. View Article : Google Scholar : PubMed/NCBI

21 

Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, et al: Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet. 28:220–221. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R and Bernard OA: Involvement of a human gene related to the drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci USA. 98:5776–5779. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Oikawa K, Ohbayashi T, Kiyono T, Nishi H, Isaka K, Umezawa A, Kuroda M and Mukai K: Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. Cancer Res. 64:3545–3549. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Oikawa K, Tanaka M, Itoh S, Takanashi M, Ozaki T, Muragaki Y and Kuroda M: A novel oncogenic pathway by TLS-CHOP involving repression of MDA-7/IL-24 expression. Br J Cancer. 106:1976–1979. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Varney SD, Betts CB, Zheng R, Wu L, Hinz B, Zhou J and Van De Water L: Hic-5 is required for myofibroblast differentiation by regulating mechanically dependent MRTF-A nuclear accumulation. J Cell Sci. 129:774–787. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Oikawa K, Ohbayashi T, Mimura J, Fujii-Kuriyama Y, Teshima S, Rokutan K, Mukai K and Kuroda M: Dioxin stimulates synthesis and secretion of IgE-dependent histamine-releasing factor. Biochem Biophys Res Commun. 290:984–987. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Oikawa K, Ishida T, Imamura T, Yoshida K, Takanashi M, Hattori H, Ishikawa A, Fujita K, Yamamoto K, Matsubayashi J, et al: Generation of the novel monoclonal antibody against TLS/EWS-CHOP chimeric oncoproteins that is applicable to one of the most sensitive assays for myxoid and round cell liposarcomas. Am J Surg Pathol. 30:351–356. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Tontonoz P, Hu E, Graves RA, Budavari AI and Spiegelman BM: mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8:1224–1234. 1994. View Article : Google Scholar : PubMed/NCBI

29 

Chawla A, Schwarz EJ, Dimaculangan DD and Lazar MA: Peroxisome proliferator-activated receptor (PPAR) gamma: Adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology. 135:798–800. 1994. View Article : Google Scholar : PubMed/NCBI

30 

Guo L, Li X and Tang QQ: Transcriptional regulation of adipocyte differentiation: A central role for CCAAT/enhancer-binding protein (C/EBP) β. J Biol Chem. 290:755–761. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Batchvarova N, Wang XZ and Ron D: Inhibition of adipogenesis by the stressinduced protein CHOP (Gadd153). EMBO J. 14:4654–4661. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Kuroda M, Ishida T, Takanashi M, Satoh M, Machinami R and Watanabe T: Oncogenic transformation and inhibition of adipocytic conversion of preadipocytes by TLS/FUS-CHOP type II chimeric protein. Am J Pathol. 151:735–744. 1997.PubMed/NCBI

33 

Rosen ED and Spiegelman BM: Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol. 16:145–171. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Gregoire FM, Smas CM and Sul HS: Understanding adipocyte differentiation. Physiol Rev. 78:783–809. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Juríková M, Danihel Ľ, Polák Š and Varga I: Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer. Acta Histochem. 118:544–552. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Malhotra U, Zaidi AH, Kosovec JE, Kasi PM, Komatsu Y, Rotoloni CL, Davison JM, Irvin CR, Hoppo T, Nason KS, et al: Prognostic value and targeted inhibition of survivin expression in esophageal adenocarcinoma and cancer-adjacent squamous epithelium. PLoS One. 8:e783432013. View Article : Google Scholar : PubMed/NCBI

37 

Oyadomari S and Mori M: Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11:381–389. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Spiegelman BM and Farmer SR: Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes. Cell. 29:53–60. 1982. View Article : Google Scholar : PubMed/NCBI

39 

Arsenijevic T, Gre´goire F, Delforge V, Delporte C and Perret J: Murine 3T3-L1 adipocyte cell differentiation model: Validated reference genes for qPCR gene expression analysis. PLoS One. 7:e375172012. View Article : Google Scholar : PubMed/NCBI

40 

Zhang J, Tang H, Zhang Y, Deng R, Shao L, Liu Y, Li F, Wang X and Zhou L: Identification of suitable reference genes for quantitative RT-PCR during 3T3-L1 adipocyte differentiation. Int J Mol Med. 33:1209–1218. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Gentile AM, Lhamyani S, Coín-Aragüez L, Oliva-Olivera W, Zayed H, Vega-Rioja A, Monteseirin J, Romero-Zerbo SY, Tinahones FJ, Bermúdez-Silva FJ and Bekay RE: RPL13A and EEF1A1 are suitable reference genes for qPCR during adipocyte differentiation of vascular stromal cells from patients with different BMI and HOMA-IR. PLoS One. 11:e01570022016. View Article : Google Scholar : PubMed/NCBI

42 

Kuroda M, Wang X, Sok J, Yin Y, Chung P, Giannotti JW, Jacobs KA, Fitz LJ, Murtha-Riel P, Turner KJ and Ron D: Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc Natl Acad Sci USA. 96:5025–5030. 1999. View Article : Google Scholar : PubMed/NCBI

43 

Perez-Mancera PA, Bermejo-Rodrıguez C, Sanchez-Martin M, Abollo-Jimenez F, Pintado B and Sanchez-Garcıa I: FUS-DDIT3 prevents the development of adipocytic precursors in liposarcoma by repressing PPARgamma and C/EBPalpha and activating eIF4E. PLoS One. 3:e25692008. View Article : Google Scholar : PubMed/NCBI

44 

Andersson MK, Goransson M, Olofsson A, Andersson C and Aman P: Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop. BMC Cancer. 10:2492010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kamikawa Y, Yokota K, Oikawa K, Sato F and Muragaki Y: Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells. Oncol Lett 20: 369, 2020.
APA
Kamikawa, Y., Yokota, K., Oikawa, K., Sato, F., & Muragaki, Y. (2020). Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells. Oncology Letters, 20, 369. https://doi.org/10.3892/ol.2020.12232
MLA
Kamikawa, Y., Yokota, K., Oikawa, K., Sato, F., Muragaki, Y."Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells". Oncology Letters 20.6 (2020): 369.
Chicago
Kamikawa, Y., Yokota, K., Oikawa, K., Sato, F., Muragaki, Y."Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells". Oncology Letters 20, no. 6 (2020): 369. https://doi.org/10.3892/ol.2020.12232
Copy and paste a formatted citation
x
Spandidos Publications style
Kamikawa Y, Yokota K, Oikawa K, Sato F and Muragaki Y: Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells. Oncol Lett 20: 369, 2020.
APA
Kamikawa, Y., Yokota, K., Oikawa, K., Sato, F., & Muragaki, Y. (2020). Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells. Oncology Letters, 20, 369. https://doi.org/10.3892/ol.2020.12232
MLA
Kamikawa, Y., Yokota, K., Oikawa, K., Sato, F., Muragaki, Y."Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells". Oncology Letters 20.6 (2020): 369.
Chicago
Kamikawa, Y., Yokota, K., Oikawa, K., Sato, F., Muragaki, Y."Suppression of MKL1 promotes adipocytic differentiation and reduces the proliferation of myxoid liposarcoma cells". Oncology Letters 20, no. 6 (2020): 369. https://doi.org/10.3892/ol.2020.12232
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team