Open Access

CLC-3 and SOX2 regulate the cell cycle in DU145 cells

  • Authors:
    • Jiahong Chen
    • Fang Wang
    • Yuli Lu
    • Shangqi Yang
    • Xueqin Chen
    • Youwei Huang
    • Xi Lin
  • View Affiliations

  • Published online on: October 21, 2020     https://doi.org/10.3892/ol.2020.12235
  • Article Number: 372
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sex determining region Y-box 2 (SOX2) is a transcription factor that serves a role in numerous different types of malignant cancer. Altered expression of chloride channel proteins has been described in a variety of malignancies. However, the association between SOX2 and chloride channel proteins is not yet fully understood. The present study investigated the association between SOX2 and chloride voltage-gated channel 3 (CLC-3) in prostate cancer. Flow cytometry demonstrated that the inactivation of CLC-3 or SOX2 arrested cell cycle progression in the G0/G1 phase. Furthermore, CLC-3 was observed to bind to SOX2, and vice versa, by co-immunoprecipitation. SOX2 appears to initiate and maintain prostate cancer tumorigenesis, in part, by modulating the cell cycle. These findings indicate the potential of SOX2 and CLC-3 as targets for the development of multi-targeted therapeutics.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen J, Wang F, Lu Y, Yang S, Chen X, Huang Y and Lin X: CLC-3 and SOX2 regulate the cell cycle in DU145 cells. Oncol Lett 20: 372, 2020
APA
Chen, J., Wang, F., Lu, Y., Yang, S., Chen, X., Huang, Y., & Lin, X. (2020). CLC-3 and SOX2 regulate the cell cycle in DU145 cells. Oncology Letters, 20, 372. https://doi.org/10.3892/ol.2020.12235
MLA
Chen, J., Wang, F., Lu, Y., Yang, S., Chen, X., Huang, Y., Lin, X."CLC-3 and SOX2 regulate the cell cycle in DU145 cells". Oncology Letters 20.6 (2020): 372.
Chicago
Chen, J., Wang, F., Lu, Y., Yang, S., Chen, X., Huang, Y., Lin, X."CLC-3 and SOX2 regulate the cell cycle in DU145 cells". Oncology Letters 20, no. 6 (2020): 372. https://doi.org/10.3892/ol.2020.12235