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Article Open Access

CLC-3 and SOX2 regulate the cell cycle in DU145 cells

  • Authors:
    • Jiahong Chen
    • Fang Wang
    • Yuli Lu
    • Shangqi Yang
    • Xueqin Chen
    • Youwei Huang
    • Xi Lin
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Department of Epidemiology and Health Statistics, School of Medicine, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Department of Pathology and Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong 510632, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 372
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    Published online on: October 21, 2020
       https://doi.org/10.3892/ol.2020.12235
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Abstract

Sex determining region Y-box 2 (SOX2) is a transcription factor that serves a role in numerous different types of malignant cancer. Altered expression of chloride channel proteins has been described in a variety of malignancies. However, the association between SOX2 and chloride channel proteins is not yet fully understood. The present study investigated the association between SOX2 and chloride voltage-gated channel 3 (CLC-3) in prostate cancer. Flow cytometry demonstrated that the inactivation of CLC-3 or SOX2 arrested cell cycle progression in the G0/G1 phase. Furthermore, CLC-3 was observed to bind to SOX2, and vice versa, by co-immunoprecipitation. SOX2 appears to initiate and maintain prostate cancer tumorigenesis, in part, by modulating the cell cycle. These findings indicate the potential of SOX2 and CLC-3 as targets for the development of multi-targeted therapeutics.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Wang F, Lu Y, Yang S, Chen X, Huang Y and Lin X: CLC-3 and SOX2 regulate the cell cycle in DU145 cells. Oncol Lett 20: 372, 2020.
APA
Chen, J., Wang, F., Lu, Y., Yang, S., Chen, X., Huang, Y., & Lin, X. (2020). CLC-3 and SOX2 regulate the cell cycle in DU145 cells. Oncology Letters, 20, 372. https://doi.org/10.3892/ol.2020.12235
MLA
Chen, J., Wang, F., Lu, Y., Yang, S., Chen, X., Huang, Y., Lin, X."CLC-3 and SOX2 regulate the cell cycle in DU145 cells". Oncology Letters 20.6 (2020): 372.
Chicago
Chen, J., Wang, F., Lu, Y., Yang, S., Chen, X., Huang, Y., Lin, X."CLC-3 and SOX2 regulate the cell cycle in DU145 cells". Oncology Letters 20, no. 6 (2020): 372. https://doi.org/10.3892/ol.2020.12235
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Wang F, Lu Y, Yang S, Chen X, Huang Y and Lin X: CLC-3 and SOX2 regulate the cell cycle in DU145 cells. Oncol Lett 20: 372, 2020.
APA
Chen, J., Wang, F., Lu, Y., Yang, S., Chen, X., Huang, Y., & Lin, X. (2020). CLC-3 and SOX2 regulate the cell cycle in DU145 cells. Oncology Letters, 20, 372. https://doi.org/10.3892/ol.2020.12235
MLA
Chen, J., Wang, F., Lu, Y., Yang, S., Chen, X., Huang, Y., Lin, X."CLC-3 and SOX2 regulate the cell cycle in DU145 cells". Oncology Letters 20.6 (2020): 372.
Chicago
Chen, J., Wang, F., Lu, Y., Yang, S., Chen, X., Huang, Y., Lin, X."CLC-3 and SOX2 regulate the cell cycle in DU145 cells". Oncology Letters 20, no. 6 (2020): 372. https://doi.org/10.3892/ol.2020.12235
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