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Article

Expression of TRPC1 and SBEM protein in breast cancer tissue and its relationship with clinicopathological features and prognosis of patients

  • Authors:
    • Yongqing Zhang
    • Xiaoqin Lun
    • Weiling Guo
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
  • Article Number: 392
    |
    Published online on: October 29, 2020
       https://doi.org/10.3892/ol.2020.12255
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Abstract

This study investigated the relationship of the expression of transient receptor potential channel 1 (TRPC1), small breast epithelial mucin (SBEM) in breast cancer tissues with clinical pathological features and prognosis of patients. Altogether 50 patients with breast cancer who were treated in Weifang People's hospital from April 2017 to November 2018 were selected, and the mRNA and protein differences of TRPC1 and SBEM in breast cancer patients and normal breast cancer tissues were detected by qRT‑PCR and Western blot. Spearman test was used for correlation analysis. Logistic univariate and multivariate analysis were performed on the risk factors related to breast cancer metastasis in breast cancer patients. The expression of TRPC1 and SBEM in breast cancer tissues was significantly higher than that in normal breast tissues (P<0.001). The mRNA expression of TRPC1, SBEM and protein was not related to age, tumor size and tissue grade of breast cancer patients, but related to TNM stage, clinical stage and lymph node metastasis (P<0.001). The relative expression of TRPC1 was positively correlated with clinical stage of breast cancer (r=0.992, P<0.001). The relative expression of SBEM was positively correlated with the clinical stage of breast cancer (r=0.853, P<0.001). The relative expression of TRPC1 was positively correlated with TNM staging of breast cancer (r=0.860, P<0.001). The relative expression of SBEM was positively correlated with TNM staging of breast cancer (r=0.880, P<0.001). Multivariate conditional Logistic regression analysis showed that TNM staging, TRPC1, SBEM were independent risk factors for malignant breast cancer metastasis. On the contrary, expression of TRPC1 and SBEM in breast cancer tissues was up‑regulated. TRPC1 and SBEM may be involved in the process of breast cancer occurrence, development and metastasis, and can be used as potential tissue biomarkers in diagnosis of breast cancer metastasis and disease assessment.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Lun X and Guo W: Expression of TRPC1 and SBEM protein in breast cancer tissue and its relationship with clinicopathological features and prognosis of patients. Oncol Lett 20: 392, 2020.
APA
Zhang, Y., Lun, X., & Guo, W. (2020). Expression of TRPC1 and SBEM protein in breast cancer tissue and its relationship with clinicopathological features and prognosis of patients. Oncology Letters, 20, 392. https://doi.org/10.3892/ol.2020.12255
MLA
Zhang, Y., Lun, X., Guo, W."Expression of TRPC1 and SBEM protein in breast cancer tissue and its relationship with clinicopathological features and prognosis of patients". Oncology Letters 20.6 (2020): 392.
Chicago
Zhang, Y., Lun, X., Guo, W."Expression of TRPC1 and SBEM protein in breast cancer tissue and its relationship with clinicopathological features and prognosis of patients". Oncology Letters 20, no. 6 (2020): 392. https://doi.org/10.3892/ol.2020.12255
Copy and paste a formatted citation
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Spandidos Publications style
Zhang Y, Lun X and Guo W: Expression of TRPC1 and SBEM protein in breast cancer tissue and its relationship with clinicopathological features and prognosis of patients. Oncol Lett 20: 392, 2020.
APA
Zhang, Y., Lun, X., & Guo, W. (2020). Expression of TRPC1 and SBEM protein in breast cancer tissue and its relationship with clinicopathological features and prognosis of patients. Oncology Letters, 20, 392. https://doi.org/10.3892/ol.2020.12255
MLA
Zhang, Y., Lun, X., Guo, W."Expression of TRPC1 and SBEM protein in breast cancer tissue and its relationship with clinicopathological features and prognosis of patients". Oncology Letters 20.6 (2020): 392.
Chicago
Zhang, Y., Lun, X., Guo, W."Expression of TRPC1 and SBEM protein in breast cancer tissue and its relationship with clinicopathological features and prognosis of patients". Oncology Letters 20, no. 6 (2020): 392. https://doi.org/10.3892/ol.2020.12255
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