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Network pharmacological systems study of Huang‑Lian‑Tang in the treatment of glioblastoma multiforme

  • Authors:
    • Wangrui Liu
    • Wenhao Xu
    • Chuanyu Li
    • Junfei Xu
    • Ke Huang
    • Renyue Hu
    • Haineng Huang
    • Xiaojuan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 20032, P.R. China, Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Obstetrics and Gynecology, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing, Jiangsu 210004, P.R. China, Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Pathogenic Biology, Medical College, Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 18
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    Published online on: November 6, 2020
       https://doi.org/10.3892/ol.2020.12279
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Abstract

Glioblastoma multiforme (GBM) has a poor prognosis and its recurrence and mortality rates are high. At present, there is no effective clinical method to control its progression and recurrence. Traditional Chinese Medicine has a high status not only in China, but also in the world. Certain drugs are also used in the clinical treatment of tumor diseases. In clinical practice, Huang‑Lian‑Tang (HLT) has proven efficacy in treating brain diseases and preventing tumor recurrence. However, the mechanisms of action have remained elusive. The present study explored the potential mechanisms of HLT in the treatment of gliomas based on network pharmacology. First, information on the composition of HLT was obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, and the composition and targets of the chemical substances contained in the herbs were analyzed. Subsequently, a pharmacological interaction network for HLT was built. Furthermore, the expressed genes of patients with GBM were obtained from Gene Expression Omnibus database and screened. A protein‑protein interaction network was then constructed for both sets of data and they were combined with a topology method for analysis. Finally, the screened genes were subjected to enrichment analysis and pathway analysis. A total of 386 candidate targets and 7 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were screened, which were mainly associated with amino acid metabolism. Gene Ontology enrichment analysis and KEGG signal pathway analysis indicated that these targets are involved in anti‑apoptosis, anti‑oxidative stress, multicellular biological processes and other physiological and pathological processes related to the occurrence and development of GBM. In conclusion, the present results indicated that the mechanisms of action of HLT against GBM involve multiple targets and signaling pathways that are related to tumorigenesis and progression. The present study not only provided a novel theoretical basis for Traditional Chinese Medicine to treat tumors but also novel ideas for the treatment of GBM.
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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Xu W, Li C, Xu J, Huang K, Hu R, Huang H and Liu X: Network pharmacological systems study of Huang‑Lian‑Tang in the treatment of glioblastoma multiforme. Oncol Lett 21: 18, 2021.
APA
Liu, W., Xu, W., Li, C., Xu, J., Huang, K., Hu, R. ... Liu, X. (2021). Network pharmacological systems study of Huang‑Lian‑Tang in the treatment of glioblastoma multiforme. Oncology Letters, 21, 18. https://doi.org/10.3892/ol.2020.12279
MLA
Liu, W., Xu, W., Li, C., Xu, J., Huang, K., Hu, R., Huang, H., Liu, X."Network pharmacological systems study of Huang‑Lian‑Tang in the treatment of glioblastoma multiforme". Oncology Letters 21.1 (2021): 18.
Chicago
Liu, W., Xu, W., Li, C., Xu, J., Huang, K., Hu, R., Huang, H., Liu, X."Network pharmacological systems study of Huang‑Lian‑Tang in the treatment of glioblastoma multiforme". Oncology Letters 21, no. 1 (2021): 18. https://doi.org/10.3892/ol.2020.12279
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Xu W, Li C, Xu J, Huang K, Hu R, Huang H and Liu X: Network pharmacological systems study of Huang‑Lian‑Tang in the treatment of glioblastoma multiforme. Oncol Lett 21: 18, 2021.
APA
Liu, W., Xu, W., Li, C., Xu, J., Huang, K., Hu, R. ... Liu, X. (2021). Network pharmacological systems study of Huang‑Lian‑Tang in the treatment of glioblastoma multiforme. Oncology Letters, 21, 18. https://doi.org/10.3892/ol.2020.12279
MLA
Liu, W., Xu, W., Li, C., Xu, J., Huang, K., Hu, R., Huang, H., Liu, X."Network pharmacological systems study of Huang‑Lian‑Tang in the treatment of glioblastoma multiforme". Oncology Letters 21.1 (2021): 18.
Chicago
Liu, W., Xu, W., Li, C., Xu, J., Huang, K., Hu, R., Huang, H., Liu, X."Network pharmacological systems study of Huang‑Lian‑Tang in the treatment of glioblastoma multiforme". Oncology Letters 21, no. 1 (2021): 18. https://doi.org/10.3892/ol.2020.12279
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