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Prognostic significance of an autophagy‑related long non‑coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma

  • Authors:
    • Qingkun Jiang
    • Danfeng Xue
    • Fanzhe Shi
    • Jiaxuan Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 29
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    Published online on: November 11, 2020
       https://doi.org/10.3892/ol.2020.12290
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Abstract

Traditional clinicopathological indices are insufficient in predicting the prognosis of patients diagnosed with oral and oropharyngeal squamous cell carcinoma (OSCC/OPSCC). Notably, autophagy and long non‑coding RNAs (lncRNAs) regulate the development and progression of various types of cancer. The present study aimed to assess the association between autophagy‑related lncRNAs and the prognosis of patients diagnosed with OSCC/OPSCC. Gene sequencing and clinicopathological data of patients with OSCC/OPSCC were downloaded from The Cancer Genome Atlas database, while gene set functional classification was downloaded from the Gene Set Enrichment Analysis database. Out of the 413 transcriptome data samples and 402 clinicopathological data samples retrieved, a total of nine autophagy‑related lncRNAs, including PTCSC2, AC099850.3, LINC01963, RTCA‑AS1, AP002884.1, UBAC2‑AS1, AL512274.1, MIR600HG and AL354733.3, were screened. This was geared towards establishing a signature through gene co‑expression network, univariate and Least Absolute Shrinkage and Selection Operator Cox regression analyses. Based on this signature, the patients were subdivided into a high‑risk group and a low‑risk group. Kaplan‑Meier survival analysis revealed that the overall survival of the high‑risk group was significantly lower than that of the low‑risk group. Furthermore, principal components analysis demonstrated that the patients diagnosed with OSCC/OPSCC could be distinguished into low‑survival and high‑survival groups according to the signature. Univariate and multivariate Cox regression analyses of clinicopathological data and the signature revealed that the signature could potentially be used as an independent prognostic factor for OSCC/OPSCC. In addition, reverse transcription‑quantitative PCR analysis of clinical samples demonstrated the validity of the signature. In summary, the present study revealed that the signature based on autophagy‑related lncRNAs potentially acts as an independent prognostic indicator for patients with OSCC/OPSCC. Furthermore, it promotes research on targeted diagnosis and treatment of patients diagnosed with OSCC/OPSCC.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Chaturvedi AK, Anderson WF, Lortet-Tieulent J, Curado MP, Ferlay J, Franceschi S, Rosenberg PS, Bray F and Gillison ML: Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. J Clin Oncol. 31:4550–4559. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Falzone L, Lupo G, La Rosa GRM, Crimi S, Anfuso CD, Salemi R, Rapisarda E, Libra M and Candido S: Identification of novel MicroRNAs and their diagnostic and prognostic significance in oral cancer. Cancers (Basel). 11:6102019. View Article : Google Scholar

4 

Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima H, Ohashi T, Idogawa M, Ogi K, Hiratsuka H, Tokino T and Sasaki Y: Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing. Oncotarget. 8:59113–59122. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Bavle RM, Venugopal R, Konda P, Muniswamappa S and Makarla S: Molecular classification of oral squamous cell carcinoma. J Clin Diagn Res. 10:ZE18–ZE21. 2016.PubMed/NCBI

6 

Wu WK, Coffelt SB, Cho CH, Wang XJ, Lee CW, Chan FK, Yu J and Sung JJ: The autophagic paradox in cancer therapy. Oncogene. 31:939–953. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Kimmelman AC: The dynamic nature of autophagy in cancer. Genes Dev. 25:1999–2010. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Lu T, Yu C, Ni H, Liang W, Yan H and Jin W: Expression of the long non-coding RNA H19 and MALAT-1 in growth hormone-secreting pituitary adenomas and its relationship to tumor behavior. Int J Dev Neurosci. 67:46–50. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Stuart JM, Segal E, Koller D and Kim SK: A gene-coexpression network for global discovery of conserved genetic modules. Science. 302:249–255. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Tibshirani R: Regression shrinkage and selection via the lasso. J R Statist Soc B. 58:267–288. 1996.

11 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Nassour J, Radford R, Correia A, Fuste JM, Schoell B, Jauch A, Shaw RJ and Karlseder J: Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 565:659–663. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp DW, Hu ZS, Su X, Maganti A, Jiang C, Lu W, et al: Autophagy maintains tumour growth through circulating arginine. Nature. 563:569–573. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Mizushima N, Yoshimori T and Ohsumi Y: The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol. 27:107–132. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Shibutani ST and Yoshimori T: A current perspective of autophagosome biogenesis. Cell Res. 24:58–68. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Levy JMM, Towers CG and Thorburn A: Targeting autophagy in cancer. Nat Rev Cancer. 17:528–542. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Chandra V, Bhagyaraj E, Parkesh R and Gupta P: Transcription factors and cognate signalling cascades in the regulation of autophagy. Biol Rev Camb Philos Soc. 91:429–451. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Bhan A, Hussain I, Ansari KI, Kasiri S, Bashyal A and Mandal SS: Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. J Mol Biol. 425:3707–3722. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Yang L, Zhang X, Li H and Liu J: The long noncoding RNA HOTAIR activates autophagy by upregulating ATG3 and ATG7 in hepatocellular carcinoma. Mol Biosyst. 12:2605–2612. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Yang Y, Jiang C, Yang Y, Guo L, Huang J, Liu X, Wu C and Zou J: Silencing of lncRNA-HOTAIR decreases drug resistance of non-small cell lung cancer cells by inactivating autophagy via suppressing the phosphorylation of ULK1. Biochem Biophys Res Commun. 497:1003–1010. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Bao X, Ren T, Huang Y, Sun K, Wang S, Liu K, Zheng B and Guo W: Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth. Cell Death Dis. 8:e26052017. View Article : Google Scholar : PubMed/NCBI

22 

YiRen H, YingCong Y, Sunwu Y, Keqin L, Xiaochun T, Senrui C, Ende C, XiZhou L and Yanfan C: Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer. Mol Cancer. 16:1742017. View Article : Google Scholar : PubMed/NCBI

23 

Guo D, Ma J, Yan L, Li T, Li Z, Han X and Shui S: Down-Regulation of Lncrna MALAT1 Attenuates neuronal cell death through suppressing Beclin1-Dependent autophagy by regulating Mir-30a in cerebral ischemic stroke. Cell Physiol Biochem. 43:182–194. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Guo X, Wu X, Han Y, Tian E and Cheng J: lncRNA MALAT1 protects cardiomyocytes from isoproterenol-induced apoptosis through sponging miR-558 to enhance ULK1-mediated protective autophagy. J Cell Physiol. 234:10842–10854. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Wang S, Yu W, Luo X, Chen J and Deng F: MALAT1/miR-204/LC3-II: A potential regulated axis of autophagy in myocardial ischemia-reperfusion injury. Int J Cardiol. 277:2222019. View Article : Google Scholar : PubMed/NCBI

26 

Tang YH, He GL, Huang SZ, Zhong KB, Liao H, Cai L, Gao Y, Peng ZW and Fu SJ: The long noncoding RNA AK002107 negatively modulates miR-140-5p and targets TGFBR1 to induce epithelial-mesenchymal transition in hepatocellular carcinoma. Mol Oncol. 13:1296–1310. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Kapusta A and Feschotte C: Volatile evolution of long noncoding RNA repertoires: Mechanisms and biological implications. Trends Genet. 30:439–452. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Zhao K, Wang M, Kang H and Wu A: A prognostic five long-noncoding RNA signature for patients with rectal cancer. J Cell Biochem. 2019.(Epub ahead of print).

29 

Zhou RS, Zhang EX, Sun QF, Ye ZJ, Liu JW, Zhou DH and Tang Y: Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue. BMC Cancer. 19:7792019. View Article : Google Scholar : PubMed/NCBI

30 

Bretin A, Carriere J, Dalmasso G, Bergougnoux A, B'Chir W, Maurin AC, Muller S, Seibold F, Barnich N, Bruhat A, et al: Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection. Autophagy. 12:770–783. 2016. View Article : Google Scholar : PubMed/NCBI

31 

B'Chir W, Maurin AC, Carraro V, Averous J, Jousse C, Muranishi Y, Parry L, Stepien G, Fafournoux P and Bruhat A: The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression. Nucleic Acids Res. 41:7683–7699. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Zhu H, Lu J, Zhao H, Chen Z, Cui Q, Lin Z, Wang X, Wang J, Dong H, Wang S and Tan J: Functional long noncoding RNAs (lncRNAs) in clear cell kidney carcinoma revealed by reconstruction and comprehensive analysis of the lncRNA-miRNA-mRNA regulatory network. Med Sci Monit. 24:8250–8263. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Chen K, Xie S and Jin W: Crucial lncRNAs associated with adipocyte differentiation from human adipose-derived stem cells based on co-expression and ceRNA network analyses. Peerj. 7:e75442019. View Article : Google Scholar : PubMed/NCBI

34 

Chen R, Zhu J, Dong Y, He C and Hu X: Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells. Oncotarget. 6:32841–32855. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Song J, Xu Q, Zhang H, Yin X, Zhu C, Zhao K and Zhu J: Five key lncRNAs considered as prognostic targets for predicting pancreatic ductal adenocarcinoma. J Cell Biochem. 119:4559–4569. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Kluge AF, Lagu BR, Maiti P, Jaleel M, Webb M, Malhotra J, Mallat A, Srinivas PA and Thompson JE: Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 28:2655–2659. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Camenisch U, Dip R, Schumacher SB, Schuler B and Naegeli H: Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair. Nat Struct Mol Biol. 13:278–284. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Ge R, Liu L, Dai W, Zhang W, Yang Y, Wang H, Shi Q, Guo S, Yi X, Wang G, et al: Xeroderma pigmentosum group A promotes autophagy to facilitate cisplatin resistance in melanoma cells through the activation of PARP1. J Invest Dermatol. 136:1219–1228. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Inoki K, Li Y, Zhu T, Wu J and Guan KL: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 4:648–657. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Di Nardo A, Han JM, et al: A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nat Cell Biol. 15:1186–1196. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Teixeira MB, Alborghetti MR and Kobarg J: Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity. World J Biol Chem. 10:28–43. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Tsang HT, Connell JW, Brown SE, Thompson A, Reid E and Sanderson CM: A systematic analysis of human CHMP protein interactions: Additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. Genomics. 88:333–346. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Barlin JN, Jelinic P, Olvera N, Bogomolniy F, Bisogna M, Dao F, Barakat RR, Chi DS and Levine DA: Validated gene targets associated with curatively treated advanced serous ovarian carcinoma. Gynecol Oncol. 128:512–517. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Li K, Liu J, Tian M, Gao G, Qi X, Pan Y, Ruan J, Liu C and Su X: CHMP4C disruption sensitizes the human lung cancer cells to irradiation. Int J Mol Sci. 17:182015. View Article : Google Scholar

45 

Cagnol S and Chambard JC: ERK and cell death: Mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence. FEBS J. 277:2–21. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Ellington AA, Berhow MA and Singletary KW: Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells. Carcinogenesis. 27:298–306. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang Q, Xue D, Shi F and Qiu J: Prognostic significance of an autophagy‑related long non‑coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma. Oncol Lett 21: 29, 2021.
APA
Jiang, Q., Xue, D., Shi, F., & Qiu, J. (2021). Prognostic significance of an autophagy‑related long non‑coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma. Oncology Letters, 21, 29. https://doi.org/10.3892/ol.2020.12290
MLA
Jiang, Q., Xue, D., Shi, F., Qiu, J."Prognostic significance of an autophagy‑related long non‑coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma". Oncology Letters 21.1 (2021): 29.
Chicago
Jiang, Q., Xue, D., Shi, F., Qiu, J."Prognostic significance of an autophagy‑related long non‑coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma". Oncology Letters 21, no. 1 (2021): 29. https://doi.org/10.3892/ol.2020.12290
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Q, Xue D, Shi F and Qiu J: Prognostic significance of an autophagy‑related long non‑coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma. Oncol Lett 21: 29, 2021.
APA
Jiang, Q., Xue, D., Shi, F., & Qiu, J. (2021). Prognostic significance of an autophagy‑related long non‑coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma. Oncology Letters, 21, 29. https://doi.org/10.3892/ol.2020.12290
MLA
Jiang, Q., Xue, D., Shi, F., Qiu, J."Prognostic significance of an autophagy‑related long non‑coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma". Oncology Letters 21.1 (2021): 29.
Chicago
Jiang, Q., Xue, D., Shi, F., Qiu, J."Prognostic significance of an autophagy‑related long non‑coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma". Oncology Letters 21, no. 1 (2021): 29. https://doi.org/10.3892/ol.2020.12290
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