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Cathepsin B is highly expressed in pancreatic cancer stem‑like cells and is associated with patients' surgical outcomes

  • Authors:
    • Takuya Fujimoto
    • Ryouichi Tsunedomi
    • Satoshi Matsukuma
    • Kiyoshi Yoshimura
    • Atsunori Oga
    • Nobuyuki Fujiwara
    • Yasuhiro Fujiwara
    • Hiroto Matsui
    • Yoshitaro Shindo
    • Yukio Tokumitsu
    • Nobuaki Suzuki
    • Shogo Kobayashi
    • Shoichi Hazama
    • Hidetoshi Eguchi
    • Hiroaki Nagano
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755‑8505, Japan, Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan, Department of Clinical Research in Tumor Immunology, Showa University Clinical Research Institute for Clinical Pharmacology and Therapeutics, Setagaya, Tokyo 157‑8577, Japan, Department of Molecular Pathology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755‑8505, Japan, Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Translational Research and Developmental Therapeutics Against Cancer, Yamaguchi University School of Medicine, Ube, Yamaguchi 755‑8505, Japan
    Copyright: © Fujimoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 30
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    Published online on: November 11, 2020
       https://doi.org/10.3892/ol.2020.12291
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Abstract

Cancer stem‑like cells (CSLCs) in solid tumors are resistant to conventional chemotherapy and molecularly targeted therapy, which is thought to contribute to cancer recurrence and metastasis. The present study aimed to identify biomarkers for pancreatic CSLCs (P‑CSLCs). Using our previously reported methods, P‑CSLC‑enriched populations were generated from pancreatic cancer cell lines. The protein expression profiles of these populations were compared with those of parental cells using two‑dimensional electrophoresis, tandem mass spectrometry, flow cytometry and immunohistochemistry. Protein expression in surgical specimens was also evaluated for relationships with clinical outcomes. A lysosomal cysteine protease, cathepsin B (CTSB), was significantly upregulated in P‑CSLCs compared with that in the parental cells, as shown using western blotting. Flow cytometry analysis also confirmed that CTSB was more highly expressed on the surface of P‑CSLCs compared with that on parental cells. Moreover, PCLCs had elevated cellular secretions of CTSB compared with the parental cells. Finally, CTSB expression was evaluated in 69 resected tumor specimens, and high expression was associated with the patients' clinicopathological features and surgical outcomes. The present results suggested that CTSB is a biomarker for poor survival in patients with pancreatic cancer, which is possibly associated with P‑CSLCs. This novel biomarker may also have potential as a therapeutic target.
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View References

1 

The Editorial Board of the Cancer Statistics in Japan, . Cancer statistics in Japan 2018. Foundation for Promotion of Cancer Research; Tokyo: pp. 152019

2 

Ryan DP, Hong TS and Bardeesy N: Pancreatic adenocarcinoma. N Engl J Med. 371:1039–1049. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Murakami T, Hiroshima Y, Matsuyama R, Homma Y, Hoffman RM and Endo I: Role of the tumor microenvironment in pancreatic cancer. Ann Gastroenterol Surg. 3:130–137. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Oettle H, Neuhaus P, Hochhaus A, Hartmann JT, Gellert K, Ridwelski K, Niedergethmann M, Zülke C, Fahlke J, Arning MB, et al: Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: The CONKO-001 randomized trial. JAMA. 310:1473–1481. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Torphy RJ, Zhu Y and Schulick RD: Immunotherapy for pancreatic cancer: Barriers and breakthroughs. Ann Gastroenterol Surg. 2:274–281. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Clevers H: The cancer stem cell: Premises, promises, and challenges. Nat Med. 17:313–319. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, Hilsenbeck SG, Pavlick A, Zhang X, Chamness GC, et al: Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst. 100:672–679. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Zhou BB, Zhang H, Damelin M, Geles KG, Grindley JC and Dirks PB: Tumour-initiating cells: Challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov. 8:806–823. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Tsunedomi R, Yoshimura K, Suzuki N, Hazama S and Nagano H: Clinical implications of cancer stem cells in digestive cancers: Acquisition of stemness and prognostic impact. Surg Today. Feb 5–2020.(Epub ahead of print). doi: 10.1007/s00595-020-01968-x. View Article : Google Scholar : PubMed/NCBI

10 

Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF and Simeone DM: Identification of pancreatic cancer stem cells. Cancer Res. 67:1030–1037. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Rasheed ZA, Yang J, Wang Q, Kowalski J, Freed I, Murter C, Hong SM, Koorstra JB, Rajeshkumar NV, He X, et al: Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma. J Natl Cancer Inst. 102:340–351. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Sureban SM, May R, Qu D, Weygant N, Chandrakesan P, Ali N, Lightfoot SA, Pantazis P, Rao CV, Postier RG and Houchen CW: DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. PLoS One. 8:e739402013. View Article : Google Scholar : PubMed/NCBI

13 

Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, Bruns CJ and Heeschen C: Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell. 1:313–323. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, Welling TH, Pasca di Magliano M and Simeone DM: c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology. 141:2218–2227. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, et al: CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc (−) and thereby promotes tumor growth. Cancer Cell. 19:387–400. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Watanabe Y, Yoshimura K, Yoshikawa K, Tsunedomi R, Shindo Y, Matsukuma S, Maeda N, Kanekiyo S, Suzuki N, Kuramasu A, et al: A stem cell medium containing neural stimulating factor induces a pancreatic cancer stem-like cell-enriched population. Int J Oncol. 45:1857–1866. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Rawlings ND, Barrett AJ and Bateman A: MEROPS: The database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res. 40:D343–D350. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Turk V, Stoka V, Vasiljeva O, Renko M, Sun T, Turk B and Turk D: Cysteine cathepsins: From structure, function and regulation to new frontiers. Biochim Biophys Acta. 1824:68–88. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Kirschke H, Barrett AJ and Rawlings ND: Proteinases 1: Lysosomal cysteine proteinases. Protein Profile. 2:1581–1643. 1995.PubMed/NCBI

20 

Mort JS and Buttle DJ: Cathepsin B. Int J Biochem Cell Biol. 29:715–720. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Aggarwal N and Sloane BF: Cathepsin B: Multiple roles in cancer. Proteomics Clin Appl. 8:427–437. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Yan S, Berquin IM, Troen BR and Sloane BF: Transcription of human cathepsin B is mediated by Sp1 and Ets family factors in glioma. DNA Cell Biol. 79:79–91. 2000. View Article : Google Scholar

23 

Li L and Davie JR: The role of Sp1 and Sp3 in normal and cancer cell biology. Ann Anat. 192:275–283. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Dittmer J: The biology of the Ets1 proto-oncogene. Mol Cancer. 2:292003. View Article : Google Scholar : PubMed/NCBI

25 

Buggy Y, Maguire TM, McGreal G, McDermott E, Hill ADK, O'Higgins N and Duffy MJ: Overexpression of the Ets-1 transcription factor in human breast cancer. Br J Cancer. 91:1308–1315. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Japan Pancreas Society: General rules for the study of pancreatic cancer, The 6th Edition, Revised Version edn. Tokyo, Japan: Kanehara; pp. 3–14. 2013

27 

Union for International Cancer Control (UICC): TNM Classification of Malignant Tumours, 7th edition. Sobin LH, Gospodarowicz MK and Wittekind C: Wiley; New York, NY: 2010

28 

Yamamoto K, Yahara N, Gondo T, Ishihara T and Oka M: Establishment and characterization of a new human pancreatic cancer cell line, YPK-1. Bull Yamaguchi Med Sch. 49:33–42. 2002.

29 

Gerashchenko BI, Yamagata A, Oofusa K, Yoshizato K, de Toledo SM and Howell RW: Proteome analysis of proliferative response of bystander cells adjacent to cells exposed to ionizing radiation. Proteomics. 7:2000–2008. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Matsukuma S, Yoshimura K, Ueno T, Oga A, Inoue M, Watanabe Y, Kuramasu A, Fuse M, Tsunedomi R, Nagaoka S, et al: Calreticulin is highly expressed in pancreatic cancer stem-like cells. Cancer Sci. 107:1599–1609. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Fujiwara N, Usui T, Ohama T and Sato K: Regulation of beclin 1 protein phosphorylation and autophagy by protein phosphatase 2A (PP2A) and death-associated protein kinase 3 (DAPK3). J Biol Chem. 291:10858–10866. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, et al: Stemness is enhanced in gastric cancer by a SET/PP2A/E2F1 axis. Mol Cancer Res. 16:554–563. 2008. View Article : Google Scholar

33 

Yabe R, Tsuji S, Mochida S, Ikehara T, Usui T, Ohama T and Sato K: A stable association with PME-1 may be dispensable for PP2A demethylation-implications for the detection of PP2A methylation and immunoprecipitation. FEBS Open Bio. 8:1486–1496. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Ebert MP, Krüger S, Fogeron ML, Lamer S, Chen J, Pross M, Schulz HU, Lage H, Heim S, Roessner A, et al: Overexpression of cathepsin B in gastric cancer identified by proteome analysis. Proteomics. 5:1693–1704. 2005. View Article : Google Scholar : PubMed/NCBI

35 

McKerrow JH, Bhargava V, Hansell E, Huling S, Kuwahara T, Matley M, Coussens L and Warren R: A functional proteomics screen of proteases in colorectal carcinoma. Mol Med. 6:450–460. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Srisomsap C, Subhasitanont P, Otto A, Mueller EC, Punyarit P, Wittmann-Liebold B and Svasti J: Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis. Proteomics. 2:706–712. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Wulfkuhle JD, Sgroi DC, Krutzsch H, McLean K, McGarvey K, Knowlton M, Chen S, Shu H, Sahin A, Kurek R, et al: Proteomics of human breast ductal carcinoma in situ. Cancer Res. 62:6740–6749. 2002.PubMed/NCBI

38 

Mijanović O, Branković A, Panin AN, Savchuk S, Timashev P, Ulasov I and Lesniak MS: Cathepsin B: A sellsword of cancer progression. Cancer Lett. 449:207–214. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Tang KD, Liu J, Jovanovic L, An J, Hill MM, Vela I, Lee TK, Ma S, Nelson C, Russell PJ, et al: Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop. Oncotarget. 7:4939–4948. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Niedergethmann M, Wostbrock B, Sturm JW, Willeke F, Post S and Hildenbrand R: Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma. Pancreas. 29:204–211. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Komura T, Takabatake H, Harada K, Yamato M, Miyazawa M, Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, et al: Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma. Cancer Sci. 108:2122–2129. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Krueger S, Haeckel C, Buehling F and Roessner A: Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line. Cancer Res. 59:6010–6014. 1999.PubMed/NCBI

43 

Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE Jr, Mammoto A, Bielenberg DR and Klagsbrun M: Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem. 288:2210–2222. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Withana NP, Blum G, Sameni M, Slaney C, Anbalagan A, Olive MB, Bidwell BN, Edgington L, Wang L, Moin K, et al: Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 72:1199–1209. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Tummalapalli P, Spomar D, Gondi CS, Olivero WC, Gujrati M, Dinh DH and Rao JS: RNAi-mediated abrogation of cathepsin B and MMP-9 gene expression in a malignant meningioma cell line leads to decreased tumor growth, invasion and angiogenesis. Int J Oncol. 31:1039–1050. 2007.PubMed/NCBI

46 

Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D and Joyce JA: Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 20:543–556. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Andl CD, McCowan KM, Allison GL and Rustgi AK: Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner. Neoplasia. 12:485–498. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Guo M, Mathieu PA, Linebaugh B, Sloane BF and Reiners JJ Jr: Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B. J Biol Chem. 277:14829–14837. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Steffan JJ, Snider JL, Skalli O, Welbourne T and Cardelli JA: Na+/H+ exchangers and RhoA regulate acidic extracellular pH-induced lysosome trafficking in prostate cancer cells. Traffic. 10:737–753. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Bayrak R, Yenidünya S and Haltas H: Cytokeratin 7 and cytokeratin 20 expression in colorectal adenocarcinoma. Pathol Res Pract. 207:156–60. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fujimoto T, Tsunedomi R, Matsukuma S, Yoshimura K, Oga A, Fujiwara N, Fujiwara Y, Matsui H, Shindo Y, Tokumitsu Y, Tokumitsu Y, et al: Cathepsin B is highly expressed in pancreatic cancer stem‑like cells and is associated with patients' surgical outcomes. Oncol Lett 21: 30, 2021.
APA
Fujimoto, T., Tsunedomi, R., Matsukuma, S., Yoshimura, K., Oga, A., Fujiwara, N. ... Nagano, H. (2021). Cathepsin B is highly expressed in pancreatic cancer stem‑like cells and is associated with patients' surgical outcomes. Oncology Letters, 21, 30. https://doi.org/10.3892/ol.2020.12291
MLA
Fujimoto, T., Tsunedomi, R., Matsukuma, S., Yoshimura, K., Oga, A., Fujiwara, N., Fujiwara, Y., Matsui, H., Shindo, Y., Tokumitsu, Y., Suzuki, N., Kobayashi, S., Hazama, S., Eguchi, H., Nagano, H."Cathepsin B is highly expressed in pancreatic cancer stem‑like cells and is associated with patients' surgical outcomes". Oncology Letters 21.1 (2021): 30.
Chicago
Fujimoto, T., Tsunedomi, R., Matsukuma, S., Yoshimura, K., Oga, A., Fujiwara, N., Fujiwara, Y., Matsui, H., Shindo, Y., Tokumitsu, Y., Suzuki, N., Kobayashi, S., Hazama, S., Eguchi, H., Nagano, H."Cathepsin B is highly expressed in pancreatic cancer stem‑like cells and is associated with patients' surgical outcomes". Oncology Letters 21, no. 1 (2021): 30. https://doi.org/10.3892/ol.2020.12291
Copy and paste a formatted citation
x
Spandidos Publications style
Fujimoto T, Tsunedomi R, Matsukuma S, Yoshimura K, Oga A, Fujiwara N, Fujiwara Y, Matsui H, Shindo Y, Tokumitsu Y, Tokumitsu Y, et al: Cathepsin B is highly expressed in pancreatic cancer stem‑like cells and is associated with patients' surgical outcomes. Oncol Lett 21: 30, 2021.
APA
Fujimoto, T., Tsunedomi, R., Matsukuma, S., Yoshimura, K., Oga, A., Fujiwara, N. ... Nagano, H. (2021). Cathepsin B is highly expressed in pancreatic cancer stem‑like cells and is associated with patients' surgical outcomes. Oncology Letters, 21, 30. https://doi.org/10.3892/ol.2020.12291
MLA
Fujimoto, T., Tsunedomi, R., Matsukuma, S., Yoshimura, K., Oga, A., Fujiwara, N., Fujiwara, Y., Matsui, H., Shindo, Y., Tokumitsu, Y., Suzuki, N., Kobayashi, S., Hazama, S., Eguchi, H., Nagano, H."Cathepsin B is highly expressed in pancreatic cancer stem‑like cells and is associated with patients' surgical outcomes". Oncology Letters 21.1 (2021): 30.
Chicago
Fujimoto, T., Tsunedomi, R., Matsukuma, S., Yoshimura, K., Oga, A., Fujiwara, N., Fujiwara, Y., Matsui, H., Shindo, Y., Tokumitsu, Y., Suzuki, N., Kobayashi, S., Hazama, S., Eguchi, H., Nagano, H."Cathepsin B is highly expressed in pancreatic cancer stem‑like cells and is associated with patients' surgical outcomes". Oncology Letters 21, no. 1 (2021): 30. https://doi.org/10.3892/ol.2020.12291
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