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Article Open Access

Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B‑cell lymphoma by counteracting miR‑331‑3p expression

  • Authors:
    • Minqing Zhang
    • Yiping Du
    • Jingmei Shang
    • Dongqing Zhang
    • Xiaoqing Dong
    • Hong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Chengwu County People's Hospital, Chengwu Hospital Affiliated to Shandong First Medical University, Heze, Shandong 274200, P.R. China, Department of Hematology, Qingdao Eighth People's Hospital, Qingdao, Shandong 266100, P.R. China, Department of Imaging, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Public Health, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Emergency Department, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Clinical Laboratory, People's Hospital of Linyi, Linyi, Shandong 276000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 39
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    Published online on: November 13, 2020
       https://doi.org/10.3892/ol.2020.12300
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Abstract

Long non‑coding RNA urothelial cancer associated 1 (UCA1) has been reported to act as a carcinogen in bladder cancer, while its role in diffuse large B‑cell lymphoma (DLBCL) remains unclear. The present study was designed to explore the expression pattern and role of UCA1 in DLBCL. The expression pattern of UCA1 and microRNA (miR)‑331‑3p in DLBCL tissues and cell lines were detected by RT‑qPCR. Dual luciferase reporter assay was performed to explore the relationship between UCA1 and miR‑331‑3p. Cell proliferation was explored by MTT assay. Cell migration and invasion abilities were assessed by Transwell assay. In the present study, it was revealed that the expression of UCA1 was significantly upregulated, while miR‑331‑3p was downregulated in DLBCL tissues and cell lines. Moreover, UCA1 was revealed to competitively bind with miR‑331‑3p in DLBCL. Functionally, knockdown of UCA1 was revealed to suppress cell proliferation, migration and invasion in DLBCL cells. Furthermore, upregulation of miR‑331‑3p prevented cell proliferation, migration and invasion in DLBC cells. In conclusion, the present findings firstly demonstrated that UCA1 silencing restrained DLBCL cell proliferation and metastases viability by suppressing miR‑331‑3p expression. It is suggested that UCA1 could be a possible medicinal target and biomarker for DLBCL.
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1 

García-Morales E, Lázaro-Martínez JL, Martínez-Hernández D, Aragón-Sánchez J, Beneit-Montesinos JV and González-Jurado MA: Impact of diabetic foot related complications on the Health Related Quality of Life (HRQol) of patients-a regional study in Spain. Int J Low Extrem Wounds. 10:6–11. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Patterson E: The spending power after NFIB: New direction, or medicaid exception? SMU Law Rev. 68:385–426. 2015.PubMed/NCBI

3 

Miao Y, Medeiros LJ, Xu-Monette ZY, Li J and Young KH: Dysregulation of cell survival in diffuse large B cell lymphoma: Mechanisms and therapeutic targets. Front Oncol. 9:1072019. View Article : Google Scholar : PubMed/NCBI

4 

Huarte M: The emerging role of lncRNAs in cancer. Nat Med. 21:1253–1261. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Gil N and Ulitsky I: Regulation of gene expression by cis-acting long non-coding RNAs. Nat Rev Genet. 21:102–117. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Liu J, Xu R, Mai SJ, Ma YS, Zhang MY, Cao PS, Weng NQ, Wang RQ, Cao D, Wei W, et al: LncRNA CSMD1-1 promotes the progression of hepatocellular carcinoma by activating MYC signaling. Theranostics. 10:7527–7544. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Huang D, Chen J, Yang L, Ouyang Q, Li J, Lao L, Zhao J, Liu J, Lu Y, Xing Y, et al: NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death. Nat Immunol. 19:1112–1125. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Mehrpour Layeghi S, Arabpour M, Esmaeili R, Naghizadeh MM, Tavakkoly Bazzaz J and Shakoori A: Evaluation of the potential role of long non-coding RNA LINC00961 in luminal breast cancer: A case-control and systems biology study. Cancer Cell Int. 20:4782020. View Article : Google Scholar : PubMed/NCBI

9 

Goie TT and Naidoo M: Awareness of diabetic foot disease amongst patients with type 2 diabetes mellitus attending the chronic outpatients department at a regional hospital in Durban, South Africa. Afr J Prim Health Care Fam Med. 8:e1–e8. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Zhao L, Liu Y, Zhang J, Liu Y and Qi Q: LncRNA SNHG14/miR-5590-3p/ZEB1 positive feedback loop promoted diffuse large B cell lymphoma progression and immune evasion through regulating PD-1/PD-L1 checkpoint. Cell Death Dis,. 10:7312019. View Article : Google Scholar

11 

Pichu S, Patel BM, Apparsundaram S and Goyal RK: Role of biomarkers in predicting diabetes complications with special reference to diabetic foot ulcers. Biomark Med. 11:377–388. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Chalatsa I, Arvanitis DA, Koulakiotis NS, Giagini A, Skaltsounis AL, Papadopoulou-Daifoti Z, Tsarbopoulos A and Sanoudou D: The Crocus sativus compounds trans-crocin 4 and trans-crocetin modulate the amyloidogenic pathway and tau misprocessing in Alzheimer disease neuronal cell culture models. Front Neurosci. 13:2492019. View Article : Google Scholar : PubMed/NCBI

13 

Hu M and Yang J: Down-regulation of lncRNA UCA1 enhances radiosensitivity in prostate cancer by suppressing EIF4G1 expression via sponging miR-331-3p. Cancer Cell Int. 20:4492020. View Article : Google Scholar : PubMed/NCBI

14 

Kocaman G, Altinoz E, Erdemli ME, Gul M, Erdemli Z, Gul S and Bag HG: Protective effects of crocin on biochemistry and histopathology of experimental periodontitis in rats. Biotech Histochem. 94:366–373. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Zhu A, Lao C, Wang Z, Chen Y and Bai C: Characterization of crocetin-monoglucuronide as a neuron-protective metabolite of crocin-1. Mol Nutr Food Res. Apr 29–2019.(Epub ahead of print). View Article : Google Scholar

16 

Khalatbari-Mohseni A, Banafshe HR, Mirhosseini N, Asemi Z, Ghaderi A and Omidi A: The effects of crocin on psychological parameters in patients under methadone maintenance treatment: A randomized clinical trial. Subst Abuse Treat Prev Policy. 14:92019. View Article : Google Scholar : PubMed/NCBI

17 

Deng L, Li J, Lu S and Su Y: Crocin inhibits proliferation and induces apoptosis through suppressing MYCN expression in retinoblastoma. J Biochem Mol Toxicol. 33:e222922019. View Article : Google Scholar : PubMed/NCBI

18 

Colapietro A, Mancini A, D'Alessandro AM and Festuccia C: Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention. Anticancer Agents Med Chem. 19:38–47. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Huang X, Qian W and Ye X: Long noncoding RNAs in diffuse large B-cell lymphoma: Current advances and perspectives. Onco Targets Ther. 13:4295–4303. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Demurtas OC, Frusciante S, Ferrante P, Diretto G, Azad NH, Pietrella M, Aprea G, Taddei AR, Romano E, Mi J, et al: Candidate enzymes for saffron crocin biosynthesis are localized in multiple cellular compartments. Plant Physiol. 177:990–1006. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Taherkhani T, Asghari Zakaria R, Omidi M and Zare N: Effect of ultrasonic waves on crocin and safranal content and expression of their controlling genes in suspension culture of saffron (Crocus sativus L). Nat Prod Res. 33:486–493. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Altinoz E, Erdemli ME, Gul M, Aksungur Z, Gul S, Bag HG, Kaya GB and Turkoz Y: Neuroprotection against CCl4 induced brain damage with crocin in Wistar rats. Biotech Histochem. 93:623–631. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Yorgun MA: Effects of crocin on diabetic maculopathy: A placebo-controlled randomized clinical trial. Am J Ophthalmol. 204:141–142. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Roshankhah S, Jalili C and Salahshoor MR: Effects of crocin on sperm parameters and seminiferous tubules in diabetic rats. Adv Biomed Res. 8:42019. View Article : Google Scholar : PubMed/NCBI

26 

Mozaffari S, Ramezany Yasuj S, Motaghinejad M, Motevalian M and Kheiri R: Crocin acting as a neuroprotective agent against methamphetamine-induced neurodegeneration via CREB-BDNF signaling pathway. Iran J Pharm Res. 18:745–758. 2019.PubMed/NCBI

27 

Komoll RM, Hu Q, Olarewaju O, von Döhlen L, Yuan Q, Xie Y, Tsay HC, Daon J, Qin R, Manns MP, et al: MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma. J Hepatol. Jul 30–2020.(Online ahead of print). View Article : Google Scholar : PubMed/NCBI

28 

Fuertes T, Ramiro AR and de Yebenes VG: miRNA-based therapies in B cell non-hodgkin lymphoma. Trends Immunol. 41:932–947. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Ting CY, Liew SM, Price A, Gan GG, Bee-Lan Ong D, Tan SY and Bee PC: Clinical significance of aberrant microRNAs expression in predicting disease relapse/refractoriness to treatment in diffuse large B-cell lymphoma: A meta-analysis. Critical Reviews in Oncology/Hematology,. 144:1028182019. View Article : Google Scholar

30 

Guo Z, Wang X, Yang Y, Chen W, Zhang K, Teng B, Huang C, Zhao Q and Qiu Z: Hypoxic tumor-derived exosomal long noncoding RNA UCA1 promotes angiogenesis via miR-96-5p/AMOTL2 in pancreatic cancer. Mol Ther Nucleic Acids. Aug 25–2020.(Epub ahead of print). View Article : Google Scholar

31 

Gao H, Yang JY, Tong LX, Jin H and Liu CZ: Long noncoding RNA UCA1 promotes proliferation and metastasis of thyroid cancer cells by sponging miR-497-3p. Eur Rev Med Pharmacol Sci,. 24:75552020.

32 

Mohammadzadeh L, Hosseinzadeh H, Abnous K and Razavi BM: Neuroprotective potential of crocin against malathion-induced motor deficit and neurochemical alterations in rats. Environ Sci Pollut Res Int. 25:4904–4914. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Lin L, Liu G and Yang L: Crocin improves cognitive behavior in rats with Alzheimer's disease by regulating endoplasmic reticulum stress and apoptosis. Biomed Res Int. 2019:94549132019. View Article : Google Scholar : PubMed/NCBI

34 

Sebastin Santhosh M, Hemshekhar M, Thushara RM, Devaraja S, Kemparaju K and Girish KS: Vipera russelli venom-induced oxidative stress and hematological alterations: Amelioration by crocin a dietary colorant. Cell Biochem Funct. 31:41–50. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Asanad K: Radiographic evolution of a simple renal cyst to clear cell renal cell carcinoma in three years. Urol Case Rep. 32:1012122020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang M, Du Y, Shang J, Zhang D, Dong X and Chen H: Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B‑cell lymphoma by counteracting miR‑331‑3p expression. Oncol Lett 21: 39, 2021.
APA
Zhang, M., Du, Y., Shang, J., Zhang, D., Dong, X., & Chen, H. (2021). Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B‑cell lymphoma by counteracting miR‑331‑3p expression. Oncology Letters, 21, 39. https://doi.org/10.3892/ol.2020.12300
MLA
Zhang, M., Du, Y., Shang, J., Zhang, D., Dong, X., Chen, H."Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B‑cell lymphoma by counteracting miR‑331‑3p expression". Oncology Letters 21.1 (2021): 39.
Chicago
Zhang, M., Du, Y., Shang, J., Zhang, D., Dong, X., Chen, H."Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B‑cell lymphoma by counteracting miR‑331‑3p expression". Oncology Letters 21, no. 1 (2021): 39. https://doi.org/10.3892/ol.2020.12300
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang M, Du Y, Shang J, Zhang D, Dong X and Chen H: Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B‑cell lymphoma by counteracting miR‑331‑3p expression. Oncol Lett 21: 39, 2021.
APA
Zhang, M., Du, Y., Shang, J., Zhang, D., Dong, X., & Chen, H. (2021). Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B‑cell lymphoma by counteracting miR‑331‑3p expression. Oncology Letters, 21, 39. https://doi.org/10.3892/ol.2020.12300
MLA
Zhang, M., Du, Y., Shang, J., Zhang, D., Dong, X., Chen, H."Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B‑cell lymphoma by counteracting miR‑331‑3p expression". Oncology Letters 21.1 (2021): 39.
Chicago
Zhang, M., Du, Y., Shang, J., Zhang, D., Dong, X., Chen, H."Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B‑cell lymphoma by counteracting miR‑331‑3p expression". Oncology Letters 21, no. 1 (2021): 39. https://doi.org/10.3892/ol.2020.12300
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