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Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China

  • Authors:
    • Wei Song
    • Yan Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 51
    |
    Published online on: November 18, 2020
       https://doi.org/10.3892/ol.2020.12312
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Abstract

The aim of the present study was to explore the clinical and pathological characteristics, diagnosis, and treatment of inflammatory myofibroblastic tumor (IMT). A total of 17 patients with IMT diagnosed between July 2010 and February 2020 were included in the present study, and the clinical characteristics, pathological features, treatment and prognosis were analyzed retrospectively. The cohort consisted of 17 participants, including 12 men and 5 women, with a mean age of 34.76 years. The most common locations of tumors were the bronchi and the lungs (9 cases, including 1 case involving the mediastinum), followed by the colon and bladder (2 cases each), and the omentum majus, mesocolon, stomach and peritoneal cavity (1 case each). Immunohistochemical staining demonstrated that the tumor cells exhibited positive staining for anaplastic lymphoma kinase p80 (13/17), smooth muscle actin (12/17), cytokeratin pan (6/17), vimentin (5/17) and desmin (4/17). The follow-up time was 18-114 months. A patient with epithelial inflammatory myofibroblast sarcoma (EIMS) succumbed to the disease, 1 case was lost to follow-up, 2 cases relapsed and the other 13 cases were considered cured. IMTs may be malignant or low-grade. EIMS is a rare and invasive variant of IMT. The clinical and imaging manifestations are often unique and vary among individuals. Once confirmed by pathology, radical surgery should be the first choice of treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Song W and Zhu Y: Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China. Oncol Lett 21: 51, 2021.
APA
Song, W., & Zhu, Y. (2021). Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China. Oncology Letters, 21, 51. https://doi.org/10.3892/ol.2020.12312
MLA
Song, W., Zhu, Y."Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China". Oncology Letters 21.1 (2021): 51.
Chicago
Song, W., Zhu, Y."Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China". Oncology Letters 21, no. 1 (2021): 51. https://doi.org/10.3892/ol.2020.12312
Copy and paste a formatted citation
x
Spandidos Publications style
Song W and Zhu Y: Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China. Oncol Lett 21: 51, 2021.
APA
Song, W., & Zhu, Y. (2021). Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China. Oncology Letters, 21, 51. https://doi.org/10.3892/ol.2020.12312
MLA
Song, W., Zhu, Y."Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China". Oncology Letters 21.1 (2021): 51.
Chicago
Song, W., Zhu, Y."Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China". Oncology Letters 21, no. 1 (2021): 51. https://doi.org/10.3892/ol.2020.12312
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