Open Access

Soluble CD40 ligand inhibits the growth of non‑Hodgkin's lymphoma cells through the JNK signaling pathway

  • Authors:
    • Zhongxin Feng
    • Jishi Wang
  • View Affiliations

  • Published online on: November 18, 2020     https://doi.org/10.3892/ol.2020.12318
  • Article Number: 56
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The incidence of non‑Hodgkin's lymphoma (NHL) has been increasing annually and has become a serious threat to human health. However, the pathogenesis of NHL remains unclear. The present study aimed to investigate the effect of soluble CD40 ligand (sCD40L) on NHL cells and its underlying mechanism. Cell Counting kit‑8 assay and flow cytometry apoptosis experiments were conducted to investigate the effects of sCD40L on cell proliferation and apoptosis. Western blotting was performed to detect the protein expression levels of BAX, Bcl‑2, ERK, p‑ERK, JNK, p‑JNK, p38, p‑p38 and c‑JUN. The results of the present study demonstrated that exogenous sCD40L significantly inhibited the proliferation and promoted the apoptosis of Raji and CA46 cells. Additionally, exogenous sCD40L promoted the apoptosis of lymphoma cells by activating the JNK signaling pathway.
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January-2021
Volume 21 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Feng Z and Feng Z: Soluble CD40 ligand inhibits the growth of non‑Hodgkin's lymphoma cells through the JNK signaling pathway. Oncol Lett 21: 56, 2021
APA
Feng, Z., & Feng, Z. (2021). Soluble CD40 ligand inhibits the growth of non‑Hodgkin's lymphoma cells through the JNK signaling pathway. Oncology Letters, 21, 56. https://doi.org/10.3892/ol.2020.12318
MLA
Feng, Z., Wang, J."Soluble CD40 ligand inhibits the growth of non‑Hodgkin's lymphoma cells through the JNK signaling pathway". Oncology Letters 21.1 (2021): 56.
Chicago
Feng, Z., Wang, J."Soluble CD40 ligand inhibits the growth of non‑Hodgkin's lymphoma cells through the JNK signaling pathway". Oncology Letters 21, no. 1 (2021): 56. https://doi.org/10.3892/ol.2020.12318