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Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma

  • Authors:
    • Li Zhao
    • Shao-Yan Liu
    • Yu-Meng Li
    • Zhong-Tang Xiong
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 72
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    Published online on: November 25, 2020
       https://doi.org/10.3892/ol.2020.12333
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Abstract

Colorectal cancer (CRC) is a common malignant tumor of digestive system. CRC with micropapillary pattern (MPP) is an aggressive variant of colorectal adenocarcinoma. The aim of the present study was to clarify the clinicopathological significance and the prognostic role of an immunohistochemical marker, MPP, in CRC. The association between MPP and clinicopathological characteristics and prognosis in 286 cases of CRC (286/453 cases had follow‑up information) were analysed. Then, 81 tissues without MPP and 90 tissues with MPP were analysed by immunohistochemistry using antibodies against villin, E‑cadherin and epithelial membrane antigen (EMA). Bioinformatics was used to evaluate the expression of these three indicators in CRC. The proportion of micropapillary carcinoma in the overall tumour was ≥5%, and was observed in 90/453 cases (19.8%). The present data showed that CRC with MPP displayed higher rates of vascular and lymphatic invasion, a higher metastatic lymph node ratio and a higher pathological tumour and metastasis stage compared with CRC without MPP. The positive expression rates of EMA, E‑cadherin and villin were 50.3, 93.4 and 96.5%, respectively. In 90 CRC cases with MPP, EMA inside‑out pattern (I/OP) staining was observed in 26 cases (28.9%), and it was often focal and partial, while 37 cases (41.1%) had E‑cadherin focal and partial staining compatible with reverse polarity. Villin I/OP staining was observed in 77 cases (85.6%), and circumferential staining predominated over partial staining. Overall, the data suggested that the presence of MPP is significantly associated with aggressive tumour behaviour and worse overall survival rate in CRC. Visualization and distinction of reverse polarity of colorectal micropapillary carcinomas is improved villin compared with EMA or E‑cadherin.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao L, Liu S, Li Y and Xiong Z: Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma. Oncol Lett 21: 72, 2021.
APA
Zhao, L., Liu, S., Li, Y., & Xiong, Z. (2021). Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma. Oncology Letters, 21, 72. https://doi.org/10.3892/ol.2020.12333
MLA
Zhao, L., Liu, S., Li, Y., Xiong, Z."Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma". Oncology Letters 21.1 (2021): 72.
Chicago
Zhao, L., Liu, S., Li, Y., Xiong, Z."Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma". Oncology Letters 21, no. 1 (2021): 72. https://doi.org/10.3892/ol.2020.12333
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao L, Liu S, Li Y and Xiong Z: Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma. Oncol Lett 21: 72, 2021.
APA
Zhao, L., Liu, S., Li, Y., & Xiong, Z. (2021). Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma. Oncology Letters, 21, 72. https://doi.org/10.3892/ol.2020.12333
MLA
Zhao, L., Liu, S., Li, Y., Xiong, Z."Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma". Oncology Letters 21.1 (2021): 72.
Chicago
Zhao, L., Liu, S., Li, Y., Xiong, Z."Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma". Oncology Letters 21, no. 1 (2021): 72. https://doi.org/10.3892/ol.2020.12333
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