Open Access

Overexpression of rhophilin 2 promotes pancreatic ductal adenocarcinoma

  • Authors:
    • Wentao Bo
    • Xielin Feng
    • Xiaoli Tang
  • View Affiliations

  • Published online on: November 25, 2020     https://doi.org/10.3892/ol.2020.12337
  • Article Number: 76
  • Copyright: © Bo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and is the seventh leading cause of global cancer deaths. In recent years, targeted therapy has been used for pancreatic cancer; however, the drugs available for use in targeted therapy for pancreatic cancer are still very limited. Hence, identification of novel targeted molecules for PDAC is required. Rhophilin 2 (RHPN2) was proven to be a driver gene in glioblastoma. However, the function of RHPN2 in PDAC remains unknown. In the present study, the function of RHPN2 was investigated. The RHPN2 levels were overexpressed by pcDNA3.1‑RHPN2 and downregulated by si‑RHPN2.Cell proliferation was assessed using the MTT assay and apoptosis was assessed using flow cytometry. The results revealed that high RHPN2 levels in PDAC tissue were correlated with a low overall survival rate of patients with PDAC. Inhibition of RHPN2 reduced SW1990 and PANC1 proliferation and increased the rate of apoptosis. Network analysis demonstrated that centrosomal protein 78 expression was negatively correlated with RHPN2 expression. In conclusion, the present study demonstrated that RHPN2 may promote PDAC making it a potential candidate for targeted therapy.
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Copy and paste a formatted citation
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Spandidos Publications style
Bo W, Feng X and Tang X: Overexpression of rhophilin 2 promotes pancreatic ductal adenocarcinoma. Oncol Lett 21: 76, 2021
APA
Bo, W., Feng, X., & Tang, X. (2021). Overexpression of rhophilin 2 promotes pancreatic ductal adenocarcinoma. Oncology Letters, 21, 76. https://doi.org/10.3892/ol.2020.12337
MLA
Bo, W., Feng, X., Tang, X."Overexpression of rhophilin 2 promotes pancreatic ductal adenocarcinoma". Oncology Letters 21.1 (2021): 76.
Chicago
Bo, W., Feng, X., Tang, X."Overexpression of rhophilin 2 promotes pancreatic ductal adenocarcinoma". Oncology Letters 21, no. 1 (2021): 76. https://doi.org/10.3892/ol.2020.12337