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Article Open Access

LINC00488 stimulates the progression of esophageal cancer by targeting microRNA‑485‑5p

Retraction in: /10.3892/ol.2022.13412
  • Authors:
    • Hongbo Xu
    • Yan Ye
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, Lu'an Affiliated Hospital of Anhui Medical University, Lu'an, Anhui 237000, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 86
    |
    Published online on: December 4, 2020
       https://doi.org/10.3892/ol.2020.12347
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Abstract

Esophageal cancer is the eighth most prevalent malignancy in the world and China has a high incidence of esophageal cancer. Previous studies have identified that LINC00488 is an oncogene; however, its role in esophageal cancer remains unclear. The present study detected the expression and biological functions of LINC00488 in the progression of esophageal cancer. LINC00488 levels in 45 esophageal cancer and matched paracancerous tissues were detected. The association between LINC00488 level, clinical indexes and overall survival rate of patients with esophageal cancer was analyzed. Using Cell Counting Kit‑8, Transwell and wound healing assays, the influence of LINC00488 on the biological functions of OE19 and OE33 cells were assessed. The target gene of LINC00488, microRNA‑485‑5p (miRNA‑485‑5p), was predicted using bioinformatics databases. In addition, the role of miRNA‑485‑5p in the progression of esophageal cancer was evaluated using rescue experiments. LINC00488 was upregulated in esophageal cancer tissues and cell lines. A high level of LINC00488 was associated with lymphatic and distant metastasis and poor prognosis in patients with esophageal cancer. Silencing LINC00488 attenuated the viability, migration and wound healing of OE19 and OE33 cells. miRNA‑485‑5p was downregulated in esophageal cancer and low expression levels predicted a poor prognosis in these patients. In addition, miRNA‑485‑5p level was negatively correlated with that of LINC00488. Rescue experiments showed that knockdown of miRNA‑485‑5p reversed the attenuated proliferation and migration of esophageal cancer cells with LINC00488‑knockdown. In conclusion, LINC00488 aggravated the malignant progression of esophageal cancer by targeting miRNA‑485‑5p.
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Copy and paste a formatted citation
Spandidos Publications style
Xu H and Ye Y: LINC00488 stimulates the progression of esophageal cancer by targeting microRNA‑485‑5p Retraction in /10.3892/ol.2022.13412. Oncol Lett 21: 86, 2021.
APA
Xu, H., & Ye, Y. (2021). LINC00488 stimulates the progression of esophageal cancer by targeting microRNA‑485‑5p Retraction in /10.3892/ol.2022.13412. Oncology Letters, 21, 86. https://doi.org/10.3892/ol.2020.12347
MLA
Xu, H., Ye, Y."LINC00488 stimulates the progression of esophageal cancer by targeting microRNA‑485‑5p Retraction in /10.3892/ol.2022.13412". Oncology Letters 21.2 (2021): 86.
Chicago
Xu, H., Ye, Y."LINC00488 stimulates the progression of esophageal cancer by targeting microRNA‑485‑5p Retraction in /10.3892/ol.2022.13412". Oncology Letters 21, no. 2 (2021): 86. https://doi.org/10.3892/ol.2020.12347
Copy and paste a formatted citation
x
Spandidos Publications style
Xu H and Ye Y: LINC00488 stimulates the progression of esophageal cancer by targeting microRNA‑485‑5p Retraction in /10.3892/ol.2022.13412. Oncol Lett 21: 86, 2021.
APA
Xu, H., & Ye, Y. (2021). LINC00488 stimulates the progression of esophageal cancer by targeting microRNA‑485‑5p Retraction in /10.3892/ol.2022.13412. Oncology Letters, 21, 86. https://doi.org/10.3892/ol.2020.12347
MLA
Xu, H., Ye, Y."LINC00488 stimulates the progression of esophageal cancer by targeting microRNA‑485‑5p Retraction in /10.3892/ol.2022.13412". Oncology Letters 21.2 (2021): 86.
Chicago
Xu, H., Ye, Y."LINC00488 stimulates the progression of esophageal cancer by targeting microRNA‑485‑5p Retraction in /10.3892/ol.2022.13412". Oncology Letters 21, no. 2 (2021): 86. https://doi.org/10.3892/ol.2020.12347
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