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Upregulation of miR-1307-3p and its function in the clinical prognosis and progression of gastric cancer

  • Authors:
    • Yanhui Ma
    • Aifeng Zhou
    • Juan Song
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory, Qingdao Central Hospital, Qingdao, Shandong 266042, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 91
    |
    Published online on: December 6, 2020
       https://doi.org/10.3892/ol.2020.12352
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Abstract

Gastric cancer is one of the major causes of cancer-associated mortality worldwide. miR-1307-3p has been demonstrated to serve multiple roles in the development of various types of cancer. The present study aimed to evaluate the expression and functional role of miR-1307-3p in the progression of gastric cancer. The expression of miR-1307-3p in gastric cancer tissues and cell lines was detected by reverse transcription quantitative PCR. Furthermore, the correlation between miR-1307-3p expression and the clinicopathological characteristics and prognosis of patients was evaluated. Cell Counting Kit-8 and Transwell assays were performed to analyze the effects of miR-1307-3p on the proliferation and the migratory and invasive abilities of gastric cancer cells, respectively. Dual-luciferase reporter assay was conducted to reveal the potential underlying mechanism of miR-1307-3p. In gastric cancer tissues and cells, miR-1307-3p expression was significantly upregulated compared with the normal tissues and cell lines. In addition, the expression of miR-1307-3p was associated with the Tumor-Node Metastasis stage of patients. The results from Cox regression analysis demonstrated that miR-1307-3p may serve as an independent predictor for the prognosis of patients with gastric cancer. Furthermore, the upregulation of miR-1307-3p in gastric cancer cell lines significantly promoted the cell proliferation and migratory and invasive abilities by targeting DAB2 interacting protein. In conclusion, the findings from the present study suggested that miR-1307-3p may serve as a tumor promoter of gastric cancer and that miR-1307-3p expression in tumor tissues may be used as a prognostic indicator for patients with gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Ma Y, Zhou A and Song J: Upregulation of miR-1307-3p and its function in the clinical prognosis and progression of gastric cancer. Oncol Lett 21: 91, 2021.
APA
Ma, Y., Zhou, A., & Song, J. (2021). Upregulation of miR-1307-3p and its function in the clinical prognosis and progression of gastric cancer. Oncology Letters, 21, 91. https://doi.org/10.3892/ol.2020.12352
MLA
Ma, Y., Zhou, A., Song, J."Upregulation of miR-1307-3p and its function in the clinical prognosis and progression of gastric cancer". Oncology Letters 21.2 (2021): 91.
Chicago
Ma, Y., Zhou, A., Song, J."Upregulation of miR-1307-3p and its function in the clinical prognosis and progression of gastric cancer". Oncology Letters 21, no. 2 (2021): 91. https://doi.org/10.3892/ol.2020.12352
Copy and paste a formatted citation
x
Spandidos Publications style
Ma Y, Zhou A and Song J: Upregulation of miR-1307-3p and its function in the clinical prognosis and progression of gastric cancer. Oncol Lett 21: 91, 2021.
APA
Ma, Y., Zhou, A., & Song, J. (2021). Upregulation of miR-1307-3p and its function in the clinical prognosis and progression of gastric cancer. Oncology Letters, 21, 91. https://doi.org/10.3892/ol.2020.12352
MLA
Ma, Y., Zhou, A., Song, J."Upregulation of miR-1307-3p and its function in the clinical prognosis and progression of gastric cancer". Oncology Letters 21.2 (2021): 91.
Chicago
Ma, Y., Zhou, A., Song, J."Upregulation of miR-1307-3p and its function in the clinical prognosis and progression of gastric cancer". Oncology Letters 21, no. 2 (2021): 91. https://doi.org/10.3892/ol.2020.12352
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