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Downregulation of lysine‑specific demethylase 1 enhances the sensitivity of hormone‑sensitive prostate cancer cells to androgen deprivation therapy

  • Authors:
    • Min Wang
    • Xiuheng Liu
    • Zhiyuan Chen
    • Lu Zhang
    • Xiaodong Weng
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 93
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    Published online on: December 6, 2020
       https://doi.org/10.3892/ol.2020.12354
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Abstract

Lysine‑specific demethylase 1 (LSD1) plays an important role in androgen receptor (AR) signaling, and LSD1 levels are associated with prostate cancer (PCa) progression. The present study investigated the association between the downregulation of LSD1 and the proliferation and invasiveness of PCa cells, as well as the effect of LSD1 on the androgen deprivation therapy (ADT)‑induced apoptosis of PCa cells. The effect of the inhibition of LSD1 combined with ADT on PCa cell apoptosis was characterized. Furthermore, the mechanisms underlying LSD1‑mediated apoptosis induced by ADT in PCa cells were investigated. Downregulation of LSD1 impaired the proliferation and invasiveness of PCa cells. Moreover, downregulation of LSD1 enhanced the apoptosis of PCa cells induced by bicalutamide in vitro. Downregulation of LSD1 decreased PSA expression, increased caspase 3 and Bax expression, decreased Bcl‑2 expression and consequently enhanced castration‑induced PCa cell apoptosis in vivo. These findings indicated that downregulation of LSD1 could effectively enhance the efficacy of ADT for hormone‑ sensitive PCa, demonstrating that this could be a promising adjunctive therapy with ADT for this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Wang M, Liu X, Chen Z, Zhang L and Weng X: Downregulation of lysine‑specific demethylase 1 enhances the sensitivity of hormone‑sensitive prostate cancer cells to androgen deprivation therapy. Oncol Lett 21: 93, 2021.
APA
Wang, M., Liu, X., Chen, Z., Zhang, L., & Weng, X. (2021). Downregulation of lysine‑specific demethylase 1 enhances the sensitivity of hormone‑sensitive prostate cancer cells to androgen deprivation therapy. Oncology Letters, 21, 93. https://doi.org/10.3892/ol.2020.12354
MLA
Wang, M., Liu, X., Chen, Z., Zhang, L., Weng, X."Downregulation of lysine‑specific demethylase 1 enhances the sensitivity of hormone‑sensitive prostate cancer cells to androgen deprivation therapy". Oncology Letters 21.2 (2021): 93.
Chicago
Wang, M., Liu, X., Chen, Z., Zhang, L., Weng, X."Downregulation of lysine‑specific demethylase 1 enhances the sensitivity of hormone‑sensitive prostate cancer cells to androgen deprivation therapy". Oncology Letters 21, no. 2 (2021): 93. https://doi.org/10.3892/ol.2020.12354
Copy and paste a formatted citation
x
Spandidos Publications style
Wang M, Liu X, Chen Z, Zhang L and Weng X: Downregulation of lysine‑specific demethylase 1 enhances the sensitivity of hormone‑sensitive prostate cancer cells to androgen deprivation therapy. Oncol Lett 21: 93, 2021.
APA
Wang, M., Liu, X., Chen, Z., Zhang, L., & Weng, X. (2021). Downregulation of lysine‑specific demethylase 1 enhances the sensitivity of hormone‑sensitive prostate cancer cells to androgen deprivation therapy. Oncology Letters, 21, 93. https://doi.org/10.3892/ol.2020.12354
MLA
Wang, M., Liu, X., Chen, Z., Zhang, L., Weng, X."Downregulation of lysine‑specific demethylase 1 enhances the sensitivity of hormone‑sensitive prostate cancer cells to androgen deprivation therapy". Oncology Letters 21.2 (2021): 93.
Chicago
Wang, M., Liu, X., Chen, Z., Zhang, L., Weng, X."Downregulation of lysine‑specific demethylase 1 enhances the sensitivity of hormone‑sensitive prostate cancer cells to androgen deprivation therapy". Oncology Letters 21, no. 2 (2021): 93. https://doi.org/10.3892/ol.2020.12354
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