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Article

Impact of Lin28 on lymph node metastasis in papillary thyroid carcinoma

  • Authors:
    • Shuxun Jin
    • Chaoyang Xu
    • Linbo Wang
    • Jiangguo Wei
    • Songxiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Thyroid Surgery, Affiliated Jiunhua Hospital, Zhejiang University School of Medicine, Jiunhua, Zhejiang 321000, P.R. China, Department of Breast and Thyroid Surgery, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang 312000, P.R. China, Department of Pathology, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang 312000, P.R. China
  • Article Number: 97
    |
    Published online on: December 7, 2020
       https://doi.org/10.3892/ol.2020.12358
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Abstract

Lin28 is involved in the progression of several types of tumors. Data collected from clinical trials have suggested that Lin28 expression is correlated with poor prognosis in thyroid carcinoma. The present study was conducted to investigate the association between Lin28 expression and the clinicopathological parameters of papillary thyroid carcinoma (PTC). Accordingly, the clinical data and diagnostic results from 237 patients with PTC were collected. Immunohistochemical staining was performed to evaluate the Lin28 expression levels in thyroid tissue samples. Associations between the expression levels and clinicopathological parameters were evaluated. Lin28 was expressed in 96/237 (40.5%) of PTC specimens. Compared with patients with no Lin28 expression, patients with expression had higher rates of lymph node metastasis (P<0.001) and larger tumors (P=0.011). Multivariate analysis revealed that Lin28 was associated with lymph node metastasis. Next, bioinformatics analysis was performed based using the Gene Expression Omnibus database and The Cancer Genome Atlas database. Lin28 expression was associated with aggressive tumor characteristics, such as lymph node metastasis and larger tumors. In conclusion, the present study revealed that Lin28 expression served as a risk factor for lymph node metastasis. Accordingly, Lin28 expression may be used as a prognostic marker to predict lymph node metastasis in patients with PTC. In addition, Lin28 may serve as a therapeutic target in the management of this tumor type, which may help improve patient outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Jin S, Xu C, Wang L, Wei J and Wang S: Impact of Lin28 on lymph node metastasis in papillary thyroid carcinoma. Oncol Lett 21: 97, 2021.
APA
Jin, S., Xu, C., Wang, L., Wei, J., & Wang, S. (2021). Impact of Lin28 on lymph node metastasis in papillary thyroid carcinoma. Oncology Letters, 21, 97. https://doi.org/10.3892/ol.2020.12358
MLA
Jin, S., Xu, C., Wang, L., Wei, J., Wang, S."Impact of Lin28 on lymph node metastasis in papillary thyroid carcinoma". Oncology Letters 21.2 (2021): 97.
Chicago
Jin, S., Xu, C., Wang, L., Wei, J., Wang, S."Impact of Lin28 on lymph node metastasis in papillary thyroid carcinoma". Oncology Letters 21, no. 2 (2021): 97. https://doi.org/10.3892/ol.2020.12358
Copy and paste a formatted citation
x
Spandidos Publications style
Jin S, Xu C, Wang L, Wei J and Wang S: Impact of Lin28 on lymph node metastasis in papillary thyroid carcinoma. Oncol Lett 21: 97, 2021.
APA
Jin, S., Xu, C., Wang, L., Wei, J., & Wang, S. (2021). Impact of Lin28 on lymph node metastasis in papillary thyroid carcinoma. Oncology Letters, 21, 97. https://doi.org/10.3892/ol.2020.12358
MLA
Jin, S., Xu, C., Wang, L., Wei, J., Wang, S."Impact of Lin28 on lymph node metastasis in papillary thyroid carcinoma". Oncology Letters 21.2 (2021): 97.
Chicago
Jin, S., Xu, C., Wang, L., Wei, J., Wang, S."Impact of Lin28 on lymph node metastasis in papillary thyroid carcinoma". Oncology Letters 21, no. 2 (2021): 97. https://doi.org/10.3892/ol.2020.12358
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