Open Access

Cardiotoxicity of anthracycline‑free targeted oncological therapies in HER2‑positive breast cancer (Review)

  • Authors:
    • Jingyuan Guan
    • Mei Zhang
  • View Affiliations

  • Published online on: December 8, 2020     https://doi.org/10.3892/ol.2020.12361
  • Article Number: 100
  • Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Anthracycline drugs are considered to be pivotal drugs in numerous chemotherapy regimens for breast cancer. However, the cardiotoxicity associated with the treatment is an important issue to be addressed. With the emergence of increasingly diverse antitumor drugs, anthracycline‑free therapies are able to reduce the cardiotoxicity caused by anthracycline drugs while ensuring that a therapeutic effect is achieved. In the present review, anthracycline‑free oncological therapy regimens for the treatment of patients with human epidermal growth factor receptor 2 (HER2)‑positive breast cancer and the associated cardiovascular toxicity are discussed, as well as some monitoring strategies. It is recommended that patients with HER2‑positive breast cancer patients should receive adjuvant chemotherapy with single or dual‑targeted therapy, with or without endocrine therapy according to the hormone receptor status determined by immunohistochemical examination. The main side effects of targeted therapy include cardiac dysfunction, hypertension and arrhythmia. According to individual risk stratification, it is recommended that patients should be periodically monitored using echocardiography, electrocardiography and serum markers, to enable the timely detection of the cardiovascular adverse reactions associated with tumor treatment, thereby preventing the morbidity and mortality caused by the cardiotoxicity of these drugs.
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February-2021
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Copy and paste a formatted citation
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Spandidos Publications style
Guan J and Guan J: Cardiotoxicity of anthracycline‑free targeted oncological therapies in HER2‑positive breast cancer (Review). Oncol Lett 21: 100, 2021
APA
Guan, J., & Guan, J. (2021). Cardiotoxicity of anthracycline‑free targeted oncological therapies in HER2‑positive breast cancer (Review). Oncology Letters, 21, 100. https://doi.org/10.3892/ol.2020.12361
MLA
Guan, J., Zhang, M."Cardiotoxicity of anthracycline‑free targeted oncological therapies in HER2‑positive breast cancer (Review)". Oncology Letters 21.2 (2021): 100.
Chicago
Guan, J., Zhang, M."Cardiotoxicity of anthracycline‑free targeted oncological therapies in HER2‑positive breast cancer (Review)". Oncology Letters 21, no. 2 (2021): 100. https://doi.org/10.3892/ol.2020.12361