The importance of surgical margins in malignant Triton tumour of the trunk and extremities

  • Authors:
    • Panagiotis Tsagozis
    • Czar Louie Gaston
    • Felix Haglund
    • Jan Balko
    • Vaiyapuri Sumathi
    • Robert Grimer
    • Michael Parry
  • View Affiliations

  • Published online on: December 15, 2020     https://doi.org/10.3892/ol.2020.12381
  • Article Number: 120
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Abstract

Malignant Triton tumour (MTT) is a rare variant of malignant peripheral nerve sheath tumour with partial rhabdomyosarcomatous differentiation. To the best of our knowledge, the importance of the surgical resection margins on the outcome of patients with MTT is unknown. The present study is a retrospective review of 24 patients treated for MTT of the trunk and the extremities between 1997 and 2015 in two institutions. The association of surgical margins with overall and tumour recurrence‑free survival was analysed. Furthermore, the typical morphological and immunohistochemical characteristics of the tumour were described. In patients treated with curative intent (17/24), a surgical margin exceeding 1 mm was significantly associated with better overall survival and local recurrence‑free survival. The oncological outcome was however poor, with only 28% of patients surviving at 5 years. Histopathologically, necrosis was a common feature, and most tumours displayed focal positivity for S100 protein and focal or strong positivity for desmin. The present results highlight the aggressive behaviour of MTTs and underline the importance of adequate surgical treatment.
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February-2021
Volume 21 Issue 2

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Spandidos Publications style
Tsagozis P, Gaston C, Haglund F, Balko J, Sumathi V, Grimer R and Parry M: The importance of surgical margins in malignant Triton tumour of the trunk and extremities. Oncol Lett 21: 120, 2021
APA
Tsagozis, P., Gaston, C., Haglund, F., Balko, J., Sumathi, V., Grimer, R., & Parry, M. (2021). The importance of surgical margins in malignant Triton tumour of the trunk and extremities. Oncology Letters, 21, 120. https://doi.org/10.3892/ol.2020.12381
MLA
Tsagozis, P., Gaston, C., Haglund, F., Balko, J., Sumathi, V., Grimer, R., Parry, M."The importance of surgical margins in malignant Triton tumour of the trunk and extremities". Oncology Letters 21.2 (2021): 120.
Chicago
Tsagozis, P., Gaston, C., Haglund, F., Balko, J., Sumathi, V., Grimer, R., Parry, M."The importance of surgical margins in malignant Triton tumour of the trunk and extremities". Oncology Letters 21, no. 2 (2021): 120. https://doi.org/10.3892/ol.2020.12381