The importance of surgical margins in malignant Triton tumour of the trunk and extremities

Tsagozis,Panagiotis; Gaston,Czar Louie; Haglund,Felix; Balko,Jan; Sumathi,Vaiyapuri; Grimer,Robert; Parry,Michael

doi:10.3892/ol.2020.12381

February-2021 Volume 21 Issue 2

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February-2021 Volume 21 Issue 2

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Article

The importance of surgical margins in malignant Triton tumour of the trunk and extremities

Authors:
- Panagiotis Tsagozis
- Czar Louie Gaston
- Felix Haglund
- Jan Balko
- Vaiyapuri Sumathi
- Robert Grimer
- Michael Parry
View Affiliations / Copyright

Affiliations: The Royal Orthopaedic Hospital Oncology Service, Royal Orthopaedic Hospital, Birmingham B31 2AP, UK, Department of Oncology‑Pathology, Karolinska Institutet, 17177 Stockholm, Sweden, Department of Musculoskeletal Pathology, Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham B31 2AP, UK
Article Number: 120
|
Published online on: December 15, 2020

https://doi.org/10.3892/ol.2020.12381
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Abstract

Malignant Triton tumour (MTT) is a rare variant of malignant peripheral nerve sheath tumour with partial rhabdomyosarcomatous differentiation. To the best of our knowledge, the importance of the surgical resection margins on the outcome of patients with MTT is unknown. The present study is a retrospective review of 24 patients treated for MTT of the trunk and the extremities between 1997 and 2015 in two institutions. The association of surgical margins with overall and tumour recurrence‑free survival was analysed. Furthermore, the typical morphological and immunohistochemical characteristics of the tumour were described. In patients treated with curative intent (17/24), a surgical margin exceeding 1 mm was significantly associated with better overall survival and local recurrence‑free survival. The oncological outcome was however poor, with only 28% of patients surviving at 5 years. Histopathologically, necrosis was a common feature, and most tumours displayed focal positivity for S100 protein and focal or strong positivity for desmin. The present results highlight the aggressive behaviour of MTTs and underline the importance of adequate surgical treatment.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The importance of surgical margins in malignant Triton tumour of the trunk and extremities

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