Comparative study of imaging and pathological evaluation of pneumonic mucinous adenocarcinoma

Han,Jun; Wu,Chongchong; Wu,Yuxin; Deng,Hui; Gao,Jie; Han,Hua; Xue,Xinying

doi:10.3892/ol.2020.12386

Comparative study of imaging and pathological evaluation of pneumonic mucinous adenocarcinoma

Authors:
- Jun Han
- Chongchong Wu
- Yuxin Wu
- Hui Deng
- Jie Gao
- Hua Han
- Xinying Xue
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Affiliations: Department of Radiology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, P.R. China, Department of Radiology, Chinese PLA General Hospital, Beijing 100853, P.R. China, Department of Radiology, The Traditional Chinese Medicine Hospital of Changshou District, Chongqing 401220, P.R. China, Department of Respiratory Diseases, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China, Department of Pathology, Chinese PLA General Hospital, Beijing 100853, P.R. China, Department of Radiology, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China
Published online on: December 17, 2020 https://doi.org/10.3892/ol.2020.12386
Article Number: 125
Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Patients with pneumonia‑type lung cancer (PTLC) do not exhibit specific clinical features, which makes imaging diagnosis difficult. Therefore, the aetiology of the pathological changes occurring during PTLC remains unclear. The current study aimed to explore the possible mechanism of PTLC formation by CT scans and pathological analysis of the lungs. A retrospective analysis was conducted on the CT and pathological data of 17 cases of PTLC. The diagnosis of lung cancer was confirmed by pathology. The CT scans of nine patients indicated diffuse distribution of lesions in the lungs, whereas those of three patients indicated single‑lung multi‑leaf distribution, and those of the remaining five patients included single‑leaf distribution. All patients demonstrated increased plaque or patchy density in the majority of the lesions located near the heart. The pathological types of the identified tumours were mucinous adenocarcinoma with adherent growth as the main sub‑type. A large number of mucus lakes were observed, containing floating tumour cells, as determined by optical microscopy. In addition, a number of tumour cells were located in the residual alveolar wall of the observed mucus lakes. The results of the present study suggested that the mucinous adenocarcinoma tumour cells produced substantial quantities of mucus, and that the cells were scattered and planted along with the mucus through the airway, which led to possible development of pneumonia‑type mucinous adenocarcinoma.

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