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Article

Potential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma

  • Authors:
    • Vincenzo Fontana
    • Maria Pia Pistillo
    • Antonella Vigani
    • Pier Aldo Canessa
    • Giovanni Berisso
    • Ugo Giannoni
    • Paola Ferro
    • Maria Cristiana Franceschini
    • Roberta Carosio
    • Marika Tonarelli
    • Paolo Dessanti
    • Silvio Roncella
  • View Affiliations / Copyright

    Affiliations: Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, I‑16132 Genova, Italy, Tumor Epigenetics Unit, IRCCS Ospedale Policlinico San Martino, I‑16132 Genova, Italy, Department of Oncology, Azienda Sanitaria Locale 5, I‑19124 La Spezia, Italy, Department of Pneumology, Azienda Sanitaria Locale 5, I‑19124 La Spezia, Italy, Department of Medicine, Azienda Sanitaria Locale 5, I‑19124 La Spezia, Italy, Department of Radiodiagnosis, Azienda Sanitaria Locale 5, I‑19124 La Spezia, Italy, Department of Histopathology and Cytopathology, Azienda Sanitaria Locale 5, I‑19124 La Spezia, Italy
  • Article Number: 128
    |
    Published online on: December 18, 2020
       https://doi.org/10.3892/ol.2020.12389
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Abstract

Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor survival rates. Therefore, it is essential to have effective biological markers predicting the course of the disease and prognosis. The aim of the present study was to highlight the prognostic significance of serum soluble mesothelin‑related protein (Se‑SMRP) in patients with MPM at diagnosis. Se‑SMRP was determined in 60 patients using an ELISA commercial kit. Se‑SMRP levels were subdivided into three tertile‑based categories and in each category overall survival (OS) indexes were determined using the Kaplan‑Meier and Cox regression analyses. The association between Se‑SMRP levels and OS was also assessed by restricted cubic spline (RCS) analysis. No notable differences in the Kaplan‑Meier probabilities were identified across the Se‑SMRP categories (<0.66 nM, 0.66‑1.46 nM, >1.46 nM) although an upward trend in death rate ratios (RR) was pointed out by comparing the higher (RR=1.95) and intermediate (RR=1.86) categories with the lower category (RR=1.00). In addition, such an increasing tendency, particularly when the biomarker exceeded 1.0 nM, was confirmed by an RCS function of Se‑SMPR levels fitted to survival data using the Cox regression equation. The present study provided evidence in favor of a prognostic value of Se‑SMRP in patients with MPM.
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Copy and paste a formatted citation
Spandidos Publications style
Fontana V, Pistillo M, Vigani A, Canessa P, Berisso G, Giannoni U, Ferro P, Franceschini M, Carosio R, Tonarelli M, Tonarelli M, et al: Potential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma. Oncol Lett 21: 128, 2021.
APA
Fontana, V., Pistillo, M., Vigani, A., Canessa, P., Berisso, G., Giannoni, U. ... Roncella, S. (2021). Potential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma. Oncology Letters, 21, 128. https://doi.org/10.3892/ol.2020.12389
MLA
Fontana, V., Pistillo, M., Vigani, A., Canessa, P., Berisso, G., Giannoni, U., Ferro, P., Franceschini, M., Carosio, R., Tonarelli, M., Dessanti, P., Roncella, S."Potential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma". Oncology Letters 21.2 (2021): 128.
Chicago
Fontana, V., Pistillo, M., Vigani, A., Canessa, P., Berisso, G., Giannoni, U., Ferro, P., Franceschini, M., Carosio, R., Tonarelli, M., Dessanti, P., Roncella, S."Potential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma". Oncology Letters 21, no. 2 (2021): 128. https://doi.org/10.3892/ol.2020.12389
Copy and paste a formatted citation
x
Spandidos Publications style
Fontana V, Pistillo M, Vigani A, Canessa P, Berisso G, Giannoni U, Ferro P, Franceschini M, Carosio R, Tonarelli M, Tonarelli M, et al: Potential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma. Oncol Lett 21: 128, 2021.
APA
Fontana, V., Pistillo, M., Vigani, A., Canessa, P., Berisso, G., Giannoni, U. ... Roncella, S. (2021). Potential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma. Oncology Letters, 21, 128. https://doi.org/10.3892/ol.2020.12389
MLA
Fontana, V., Pistillo, M., Vigani, A., Canessa, P., Berisso, G., Giannoni, U., Ferro, P., Franceschini, M., Carosio, R., Tonarelli, M., Dessanti, P., Roncella, S."Potential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma". Oncology Letters 21.2 (2021): 128.
Chicago
Fontana, V., Pistillo, M., Vigani, A., Canessa, P., Berisso, G., Giannoni, U., Ferro, P., Franceschini, M., Carosio, R., Tonarelli, M., Dessanti, P., Roncella, S."Potential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma". Oncology Letters 21, no. 2 (2021): 128. https://doi.org/10.3892/ol.2020.12389
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