Open Access

Function of p21 and its therapeutic effects in esophageal cancer (Review)

  • Authors:
    • Lei Wang
    • Huiqiong Han
    • Lin Dong
    • Zehua Wang
    • Yanru Qin
  • View Affiliations

  • Published online on: December 20, 2020     https://doi.org/10.3892/ol.2020.12397
  • Article Number: 136
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Esophageal cancer (EC) is the eighth most common type of cancer worldwide and ranks sixth among the causes of cancer‑related mortality. Due to the high mortality rate and poor treatment efficacy for EC, millions of individuals succumb to this disease; thus, the identification of novel treatment targets is of utmost importance and urgency. In recent years, there have been advances if therapies targeting cell cycle regulators. p21 is a type of cell cycle regulator that plays a dual role in tumor cells, as it can not only regulate the cell cycle, induce apoptosis and inhibit cell proliferation, but can also protect cells from apoptosis. It has been found that p21 often exerts a tumor‑suppressive effect on EC, which provides a basis for its use as a treatment target for EC. Therefore, the aim of the present study was to review the function of p21 and its potential value as a therapeutic target for EC.
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February-2021
Volume 21 Issue 2

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Copy and paste a formatted citation
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Spandidos Publications style
Wang L, Han H, Dong L, Wang Z and Qin Y: Function of p21 and its therapeutic effects in esophageal cancer (Review). Oncol Lett 21: 136, 2021
APA
Wang, L., Han, H., Dong, L., Wang, Z., & Qin, Y. (2021). Function of p21 and its therapeutic effects in esophageal cancer (Review). Oncology Letters, 21, 136. https://doi.org/10.3892/ol.2020.12397
MLA
Wang, L., Han, H., Dong, L., Wang, Z., Qin, Y."Function of p21 and its therapeutic effects in esophageal cancer (Review)". Oncology Letters 21.2 (2021): 136.
Chicago
Wang, L., Han, H., Dong, L., Wang, Z., Qin, Y."Function of p21 and its therapeutic effects in esophageal cancer (Review)". Oncology Letters 21, no. 2 (2021): 136. https://doi.org/10.3892/ol.2020.12397