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L‑fucose ameliorates the carcinogenic properties of Fusobacterium nucleatum in colorectal cancer

  • Authors:
    • Caihan Duan
    • Xuelian Tang
    • Weijun Wang
    • Wei Qian
    • Xiaochao Fu
    • Xiaohua Deng
    • Chaoqun Han
    • Xiaohua Hou
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430020, P.R. China, Hubei Center of Industrial Culture Collection and Research, Wuhan, Hubei 430020, P.R. China
    Copyright: © Duan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 143
    |
    Published online on: December 21, 2020
       https://doi.org/10.3892/ol.2020.12404
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Abstract

Fusobacterium nucleatum (Fn) is considered a promoting factor in colorectal cancer (CRC); however, only a few studies have investigated therapies against Fn. L‑fucose is a natural monosaccharide that has prebiotic potential. The present study aimed to investigate the effect of L‑fucose on the carcinogenic properties of Fn. The HCT116 and SW480 colon cancer cell lines were treated with Fn and Fn+L‑fucose (Fnf), respectively. The Cell Counting Kit‑8 (CCK‑8), colony formation, Transwell migration and invasion and wound healing assays were performed to assess the proliferative, migratory and invasive abilities of the cells, respectively. Western blot was performed to detect the protein levels of jak/stat3 pathway components and EMT. The results of the CCK‑8, colony formation, Transwell and wound healing assays demonstrated that treatment with Fn significantly enhanced the proliferative, migratory and invasive abilities of HCT116 and SW480 colon cancer cells. Notably, these effects were significantly reversed following addition of L‑fucose. Furthermore, L‑fucose inhibited the carcinogenic properties of Fn to activate the stat3 pathway and epithelial‑to‑mesenchymal transition. Taken together, the results of the present study suggest that L‑fucose ameliorates the carcinogenic properties of Fn in vitro, and thus may serve as a novel therapeutic target for flora‑related colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Duan C, Tang X, Wang W, Qian W, Fu X, Deng X, Han C and Hou X: L‑fucose ameliorates the carcinogenic properties of <em>Fusobacterium nucleatum</em> in colorectal cancer. Oncol Lett 21: 143, 2021.
APA
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X. ... Hou, X. (2021). L‑fucose ameliorates the carcinogenic properties of <em>Fusobacterium nucleatum</em> in colorectal cancer. Oncology Letters, 21, 143. https://doi.org/10.3892/ol.2020.12404
MLA
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X., Han, C., Hou, X."L‑fucose ameliorates the carcinogenic properties of <em>Fusobacterium nucleatum</em> in colorectal cancer". Oncology Letters 21.2 (2021): 143.
Chicago
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X., Han, C., Hou, X."L‑fucose ameliorates the carcinogenic properties of <em>Fusobacterium nucleatum</em> in colorectal cancer". Oncology Letters 21, no. 2 (2021): 143. https://doi.org/10.3892/ol.2020.12404
Copy and paste a formatted citation
x
Spandidos Publications style
Duan C, Tang X, Wang W, Qian W, Fu X, Deng X, Han C and Hou X: L‑fucose ameliorates the carcinogenic properties of <em>Fusobacterium nucleatum</em> in colorectal cancer. Oncol Lett 21: 143, 2021.
APA
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X. ... Hou, X. (2021). L‑fucose ameliorates the carcinogenic properties of <em>Fusobacterium nucleatum</em> in colorectal cancer. Oncology Letters, 21, 143. https://doi.org/10.3892/ol.2020.12404
MLA
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X., Han, C., Hou, X."L‑fucose ameliorates the carcinogenic properties of <em>Fusobacterium nucleatum</em> in colorectal cancer". Oncology Letters 21.2 (2021): 143.
Chicago
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X., Han, C., Hou, X."L‑fucose ameliorates the carcinogenic properties of <em>Fusobacterium nucleatum</em> in colorectal cancer". Oncology Letters 21, no. 2 (2021): 143. https://doi.org/10.3892/ol.2020.12404
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