Open Access

Dual roles of myeloid‑derived suppressor cells induced by Toll‑like receptor signaling in cancer (Review)

  • Authors:
    • Hongyue Zhou
    • Mengyu Jiang
    • Hongyan Yuan
    • Weihua Ni
    • Guixiang Tai
  • View Affiliations

  • Published online on: December 24, 2020     https://doi.org/10.3892/ol.2020.12410
  • Article Number: 149
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Myeloid‑derived suppressor cells (MDSCs) are one of the major components of the tumor microenvironment (TME), and are the main mediators of tumor‑induced immunosuppression. Recent studies have reported that the survival, differentiation and immunosuppressive activity of MDSCs are affected by the Toll‑like receptor (TLR) signaling pathway. However, the regulatory effect of TLR signaling on MDSCs remains controversial. TLR‑induced MDSC can acquire different immunosuppressive activities to influence the immune response that can be either beneficial or detrimental to cancer immunotherapy. The present review summarizes the effects of TLR signals on the number, phenotype and inhibitory activity of MDSCs, and their role in cancer immunotherapy, which cannot be ignored if effective cancer immunotherapies are to be developed for the immunosuppression of the TME.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou H, Jiang M, Yuan H, Ni W and Tai G: Dual roles of myeloid‑derived suppressor cells induced by Toll‑like receptor signaling in cancer (Review). Oncol Lett 21: 149, 2021
APA
Zhou, H., Jiang, M., Yuan, H., Ni, W., & Tai, G. (2021). Dual roles of myeloid‑derived suppressor cells induced by Toll‑like receptor signaling in cancer (Review). Oncology Letters, 21, 149. https://doi.org/10.3892/ol.2020.12410
MLA
Zhou, H., Jiang, M., Yuan, H., Ni, W., Tai, G."Dual roles of myeloid‑derived suppressor cells induced by Toll‑like receptor signaling in cancer (Review)". Oncology Letters 21.2 (2021): 149.
Chicago
Zhou, H., Jiang, M., Yuan, H., Ni, W., Tai, G."Dual roles of myeloid‑derived suppressor cells induced by Toll‑like receptor signaling in cancer (Review)". Oncology Letters 21, no. 2 (2021): 149. https://doi.org/10.3892/ol.2020.12410