Open Access

Curcumin suppresses colorectal tumorigenesis via the Wnt/β‑catenin signaling pathway by downregulating Axin2

  • Authors:
    • Jiaxue Hao
    • Xufen Dai
    • Juan Gao
    • Yuexuan Li
    • Zhaoling Hou
    • Zhongman Chang
    • Yuxin Wang
  • View Affiliations

  • Published online on: January 6, 2021     https://doi.org/10.3892/ol.2021.12447
  • Article Number: 186
  • Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is the third most common cancer worldwide, with high incidence and mortality rates. Conventional therapies, including surgery, chemotherapy and radiation, are extensively used for the treatment of CRC. However, patients present with adverse effects, such as toxicity, hepatic injury and drug resistance. Thus, there is an urgent requirement to identify effective and safe therapy for CRC. Curcumin (CUR), a polyphenol substrate extracted from the rhizome of Curcuma longa, has been extensively studied for the treatment of CRC due to its high efficacy and fewer side effects. Previous studies have reported that several signaling pathways, such as NF‑κB, Wnt/β‑catenin, are involved in the antitumor effects of CUR in vitro. However, the effect and mechanisms in vivo are not yet fully understood. The present study aimed to determine the molecular mechanism of colorectal cancer in vivo. Reverse transcription‑quantitative PCR, western blot and immunohistochemistry analyses were performed to determine the underlying molecular mechanism of curcumin's anti‑cancer effect in azoxymethane‑dextran sodium sulfate induced colorectal cancer. The results of the present study demonstrated that CUR suppressed tumorigenesis in AOM‑DSS induced CRC in mice, and anticancer effects were exerted by suppressing the expression of pro‑inflammatory cytokines, and downregulating Axin2 in the Wnt/β‑catenin signaling pathway. Taken together, these results exhibit the potential in vivo mechanisms of the anticancer effects of CUR, and highlight Axin2 as a potential therapeutic target for CRC.
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March-2021
Volume 21 Issue 3

Print ISSN: 1792-1074
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Spandidos Publications style
Hao J, Dai X, Gao J, Li Y, Hou Z, Chang Z and Wang Y: Curcumin suppresses colorectal tumorigenesis via the Wnt/β‑catenin signaling pathway by downregulating Axin2. Oncol Lett 21: 186, 2021
APA
Hao, J., Dai, X., Gao, J., Li, Y., Hou, Z., Chang, Z., & Wang, Y. (2021). Curcumin suppresses colorectal tumorigenesis via the Wnt/β‑catenin signaling pathway by downregulating Axin2. Oncology Letters, 21, 186. https://doi.org/10.3892/ol.2021.12447
MLA
Hao, J., Dai, X., Gao, J., Li, Y., Hou, Z., Chang, Z., Wang, Y."Curcumin suppresses colorectal tumorigenesis via the Wnt/β‑catenin signaling pathway by downregulating Axin2". Oncology Letters 21.3 (2021): 186.
Chicago
Hao, J., Dai, X., Gao, J., Li, Y., Hou, Z., Chang, Z., Wang, Y."Curcumin suppresses colorectal tumorigenesis via the Wnt/β‑catenin signaling pathway by downregulating Axin2". Oncology Letters 21, no. 3 (2021): 186. https://doi.org/10.3892/ol.2021.12447