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Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer

  • Authors:
    • Yuhai Zhang
    • Yuling Hong
    • Dan Wang
    • Linshan Duan
    • Yanling Liu
    • Long Li
    • Di Liu
    • Kunbin Zhuang
    • Chaoxin Wei
    • Guogeng Zheng
    • Chunyong Huo
    • Guoyan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, Xiamen, Fujian 361004, P.R. China, Department of Basic Medicine, Medical College of Xiamen University, Xiamen, Fujian 361000, P.R. China, Department of Cancer Prevention and Rehabilitation, Huayan Science and Technology Cancer Prevention and Rehabilitation Research Center, School of Pharmaceutical Sciences Xiamen University, Xiamen, Fujian 361102, P.R. China, School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian 350000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 220
    |
    Published online on: January 21, 2021
       https://doi.org/10.3892/ol.2021.12481
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Abstract

Recent studies have demonstrated that circular RNAs (circRNAs) play an important role in the development of gastric cancer (GC). The present study aimed to investigate the role of hsa_circ_0076305 (circPGC) in GC. The levels of circRNAs and mRNAs in AGS cell lines were detected via reverse transcription‑quantitative PCR, and western blotting was performed to detect protein expression levels. Functional studies were explored by CCK8 assay and cell migration assay. Functional studies have indicated that circPGC orchestrates two cellular processes; it inhibits proliferation, and promotes migration and invasion in the GC AGS cell line, a phenomenon called ‘migration‑proliferation dichotomy’, as well as epithelial‑to‑mesenchymal transition in AGS cells. In addition, circPGC degrades the extracellular matrix and basement membrane through matrix metallopeptidase (MMP)9 and MMP14, providing a microenvironment that facilitates cell migration. The results also demonstrated that circPGC expression is lower in clinical patients with later stages of GC, which is associated with poor prognosis. Taken together, these results suggest that circPGC exhibits migration‑proliferation dichotomy during GC development, invasion and migration.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Hong Y, Wang D, Duan L, Liu Y, Li L, Liu D, Zhuang K, Wei C, Zheng G, Zheng G, et al: Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer. Oncol Lett 21: 220, 2021.
APA
Zhang, Y., Hong, Y., Wang, D., Duan, L., Liu, Y., Li, L. ... Liu, G. (2021). Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer. Oncology Letters, 21, 220. https://doi.org/10.3892/ol.2021.12481
MLA
Zhang, Y., Hong, Y., Wang, D., Duan, L., Liu, Y., Li, L., Liu, D., Zhuang, K., Wei, C., Zheng, G., Huo, C., Liu, G."Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer". Oncology Letters 21.3 (2021): 220.
Chicago
Zhang, Y., Hong, Y., Wang, D., Duan, L., Liu, Y., Li, L., Liu, D., Zhuang, K., Wei, C., Zheng, G., Huo, C., Liu, G."Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer". Oncology Letters 21, no. 3 (2021): 220. https://doi.org/10.3892/ol.2021.12481
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Hong Y, Wang D, Duan L, Liu Y, Li L, Liu D, Zhuang K, Wei C, Zheng G, Zheng G, et al: Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer. Oncol Lett 21: 220, 2021.
APA
Zhang, Y., Hong, Y., Wang, D., Duan, L., Liu, Y., Li, L. ... Liu, G. (2021). Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer. Oncology Letters, 21, 220. https://doi.org/10.3892/ol.2021.12481
MLA
Zhang, Y., Hong, Y., Wang, D., Duan, L., Liu, Y., Li, L., Liu, D., Zhuang, K., Wei, C., Zheng, G., Huo, C., Liu, G."Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer". Oncology Letters 21.3 (2021): 220.
Chicago
Zhang, Y., Hong, Y., Wang, D., Duan, L., Liu, Y., Li, L., Liu, D., Zhuang, K., Wei, C., Zheng, G., Huo, C., Liu, G."Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer". Oncology Letters 21, no. 3 (2021): 220. https://doi.org/10.3892/ol.2021.12481
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