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Lycorine hydrochloride induces reactive oxygen species‑mediated apoptosis via the mitochondrial apoptotic pathway and the JNK signaling pathway in the oral squamous cell carcinoma HSC‑3 cell line

  • Authors:
    • Min-Hui Li
    • Xin Liao
    • Chen Li
    • Tian-Tian Wang
    • Yi-Song Sun
    • Kang Yang
    • Pei-Wen Jiang
    • Song-Ting Shi
    • Wen-Xin Zhang
    • Kun Zhang
    • Chao Li
    • Ping Yang
  • View Affiliations / Copyright

    Affiliations: Center of Science and Research, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China, School of Bioscience and Technology, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China, School of Basic Medicine, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China, School of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China, Department of Head and Neck Surgery, Sichuan Cancer Hospital and Institute, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 236
    |
    Published online on: January 26, 2021
       https://doi.org/10.3892/ol.2021.12497
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Abstract

Poor drug efficacy is a prominent cause of oral squamous cell carcinoma (OSCC) treatment failure. Although increased efforts in developing OSCC therapeutic strategies have been achieved in recent decades, the 5‑year survival rate of patients with OSCC remains poor and effective drugs to treat OSCC are lacking. The aim of the present study was to investigate the apoptotic effect caused by lycorine hydrochloride (LH) and to identify its mechanism in the OSCC HSC‑3 cell line. The findings demonstrated that LH effectively induced HSC‑3 cell apoptosis and cell cycle arrest at the G0/G1 phase, resulting in the inhibition of cell proliferation. Furthermore, it was found that LH increased reactive oxygen species (ROS) production, triggered mitochondrial membrane potential (MMP) disorder, enhanced the protein expression levels of Bax, Bim, cleaved caspase‑9, caspase‑3 and poly(ADP‑ribose) polymerase 1 and decreased Mcl‑1 expression. The protein expression levels of important members of the JNK signaling pathway, including phosphorylated (p)‑JNK, p‑mitogen‑activated protein kinase kinase 4 and p‑c‑Jun, were significantly increased in LH‑treated cells, accompanied by an increase in ROS. However, N‑acetyl cysteine (NAC), a potent antioxidant, reversed the upregulated mRNA expression of c‑Jun, as well as the enhanced ROS production, the disorder of MMP and the apoptosis of HSC‑3 cells induced by LH. These results suggested that LH may induce HSC‑3 cell apoptosis via the ROS‑mediated mitochondrial apoptotic pathway and the JNK signaling pathway, which indicated that LH may be a potential drug candidate for anti‑OSCC therapy.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A and Bray F: Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 144:1941–1953. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Wei M, Wu Y, Liu H and Xie C: Genipin induces autophagy and suppresses cell growth of oral squamous cell carcinoma via PI3K/AKT/MTOR pathway. Drug Des Devel Ther. 14:395–405. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Su L, Wang S, Yuan T, Xie X, Fu X, Ji P, Zhong L and Liu W: Anti-oral squamous cell carcinoma effects of a potent TAZ inhibitor AR-42. J Cancer. 11:364–373. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Xu Z, Jiang P and He S: Identification for exploring underlying pathogenesis and therapy strategy of oral squamous cell carcinoma by bioinformatics analysis. Med Sci Monit. 25:9216–9226. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefèbvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, et al: Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 350:1945–1952. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK and Lefèbvre JL: Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 27:843–850. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Ju WT, Ma HL, Zhao TC, Liang SY, Zhu DW, Wang LZ, Li J, Zhang ZY, Zhou G and Zhong LP: Stathmin guides personalized therapy in oral squamous cell carcinoma. Cancer Sci. 111:1303–1313. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Thiagarajan S, Dhar H, Bhattacharjee A, Fatehi KS, Shah SB, Chaukar D, Nair D, Deshmukh A, Prabhash K, Joshi A, et al: Patterns of failure and outcomes in cT4 Oral squamous cell carcinoma (OSCC) undergoing upfront surgery in comparison to neo-adjuvant chemotherapy (NACT) followed by surgery: A matched pair analysis. Oral Oncol. 100:1044552020. View Article : Google Scholar : PubMed/NCBI

10 

Utaipan T, Boonyanuphong P, Chuprajob T, Suksamrarn A and Chunglok W: A trienone analog of curcumin, 1,7-bis(3-hydroxyphenyl)-1,4,6-heptatrien-3-one, possesses ROS- and caspase-mediated apoptosis in human oral squamous cell carcinoma cells in vitro. Appl Biol Chem. 63:72020. View Article : Google Scholar

11 

Wang C, Liu XQ, Hou JS, Wang JN and Huang HZ: Molecular mechanisms of chemoresistance in oral cancer. Chin J Dent Res. 19:25–33. 2016.PubMed/NCBI

12 

Shah O'Brien P, Xi Y, Miller JR, Brownell AL, Zeng Q, Yoo GH, Garshott DM, O'Brien MB, Galinato AE, Cai P, et al: Disulfiram (Antabuse) activates ROS-dependent ER stress and apoptosis in oral cavity squamous cell carcinoma. J Clin Med. 8:6112019. View Article : Google Scholar

13 

Yu CI, Chen CY, Liu W, Chang PC, Huang CW, Han KF, Lin IP, Lin MY and Lee CH: Sandensolide induces oxidative stress-mediated apoptosis in oral cancer cells and in zebrafish xenograft model. Mar Drugs. 16:3872018. View Article : Google Scholar

14 

Dias RB, de Araújo TBS, de Freitas RD, Rodrigues ACBDC, Sousa LP, Sales CBS, Valverde LF, Soares MBP, Dos Reis MG, Coletta RD, et al: β-Lapachone and its iodine derivatives cause cell cycle arrest at G 2/M phase and reactive oxygen species-mediated apoptosis in human oral squamous cell carcinoma cells. Free Radic Biol Med. 126:87–100. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Ansari SS, Sharma AK, Soni H, Ali DM, Tews B, König R, Eibl H and Berger MR: Induction of ER and mitochondrial stress by the alkylphosphocholine erufosine in oral squamous cell carcinoma cells. Cell Death Dis. 9:2962018. View Article : Google Scholar : PubMed/NCBI

16 

Cao Z, Yu D, Fu S, Zhang G, Pan Y, Bao M, Tu J, Shang B, Guo P, Yang P and Zhou Q: Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicol Lett. 218:174–185. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Ji Y, Yu M, Qi Z, Cui D, Xin G, Wang B, Jia W and Chang L: Study on apoptosis effect of human breast cancer cell MCF-7 induced by lycorine hydrochloride via death receptor pathway. Saudi Pharm J. 25:633–637. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Xin G, Yu M, Hu Y, Gao S, Sun Y, Yu W, He J and Ji Y: Effect of lycorine on the structure and function of hepatoma cell membrane in vitro and in vivo. Biotech Biotechnol Equip. 34:104–114. 2020. View Article : Google Scholar

19 

Lamoral-Theys D, Andolfi A, Van Goietsenoven G, Cimmino A, Le Calvé B, Wauthoz N, Mégalizzi V, Gras T, Bruyère C, Dubois J, et al: Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: An investigation of structure-activity relationship and mechanistic insight. J Med Chem. 52:6244–6256. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Wang C, Wang Q, Li X, Jin Z, Xu P, Xu N, Xu A, Xu Y, Zheng S, Zheng J, et al: Lycorine induces apoptosis of bladder cancer T24 cells by inhibiting phospho-Akt and activating the intrinsic apoptotic cascade. Biochem Biophys Res Commun. 483:197–202. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Sharma A, Boise LH and Shanmugam M: Cancer metabolism and the evasion of apoptotic cell death. Cancers (Basel). 11:11442019. View Article : Google Scholar

23 

L Z: Progress on comprehensive treatment of nasopharyngeal cancer. Cancer Res Prev Treat. 46:667–671. 2019.

24 

An W, Lai H, Zhang Y, Liu M, Lin X and Cao S: Apoptotic pathway as the therapeutic target for anticancer traditional Chinese medicines. Front Pharmacol. 10:7582019. View Article : Google Scholar : PubMed/NCBI

25 

Roy M, Liang L, Xiao X, Feng P, Ye M and Liu J: Lycorine: A prospective natural lead for anticancer drug discovery. Biomed Pharmacother. 107:615–624. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Zhao G, Wang Y, Yang C, Zhao L, Guo L, Li L and Wei Z: Interplay between autophagy and apoptosis in lycorine hydrochloride-induced cytotoxicity of HCT116 cells. Nat Prod Commun. 14:1934578X19862102019. View Article : Google Scholar

27 

Li MH, Yang P, Yang T, Zhang K, Liu Y, Liu J, Li LM, Luo XY, Yang SX, Zou Q and Zhang CJ: A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways. Int J Oncol. 49:2127–2134. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Tomicic MT, Meise R, Aasland D, Berte N, Kitzinger R, Krämer OH, Kaina B and Christmann M: Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. Oncotarget. 6:33755–33768. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Uzu M, Sato H, Shimizu A, Shibata Y, Ueno K and Hisaka A: Connexin 43 enhances Bax activation via JNK activation in sunitinib-induced apoptosis in mesothelioma cells. J Pharmacol Sci. 134:101–107. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li M, Liao X, Li C, Wang T, Sun Y, Yang K, Jiang P, Shi S, Zhang W, Zhang K, Zhang K, et al: Lycorine hydrochloride induces reactive oxygen species‑mediated apoptosis via the mitochondrial apoptotic pathway and the JNK signaling pathway in the oral squamous cell carcinoma HSC‑3 cell line. Oncol Lett 21: 236, 2021.
APA
Li, M., Liao, X., Li, C., Wang, T., Sun, Y., Yang, K. ... Yang, P. (2021). Lycorine hydrochloride induces reactive oxygen species‑mediated apoptosis via the mitochondrial apoptotic pathway and the JNK signaling pathway in the oral squamous cell carcinoma HSC‑3 cell line. Oncology Letters, 21, 236. https://doi.org/10.3892/ol.2021.12497
MLA
Li, M., Liao, X., Li, C., Wang, T., Sun, Y., Yang, K., Jiang, P., Shi, S., Zhang, W., Zhang, K., Li, C., Yang, P."Lycorine hydrochloride induces reactive oxygen species‑mediated apoptosis via the mitochondrial apoptotic pathway and the JNK signaling pathway in the oral squamous cell carcinoma HSC‑3 cell line". Oncology Letters 21.3 (2021): 236.
Chicago
Li, M., Liao, X., Li, C., Wang, T., Sun, Y., Yang, K., Jiang, P., Shi, S., Zhang, W., Zhang, K., Li, C., Yang, P."Lycorine hydrochloride induces reactive oxygen species‑mediated apoptosis via the mitochondrial apoptotic pathway and the JNK signaling pathway in the oral squamous cell carcinoma HSC‑3 cell line". Oncology Letters 21, no. 3 (2021): 236. https://doi.org/10.3892/ol.2021.12497
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Liao X, Li C, Wang T, Sun Y, Yang K, Jiang P, Shi S, Zhang W, Zhang K, Zhang K, et al: Lycorine hydrochloride induces reactive oxygen species‑mediated apoptosis via the mitochondrial apoptotic pathway and the JNK signaling pathway in the oral squamous cell carcinoma HSC‑3 cell line. Oncol Lett 21: 236, 2021.
APA
Li, M., Liao, X., Li, C., Wang, T., Sun, Y., Yang, K. ... Yang, P. (2021). Lycorine hydrochloride induces reactive oxygen species‑mediated apoptosis via the mitochondrial apoptotic pathway and the JNK signaling pathway in the oral squamous cell carcinoma HSC‑3 cell line. Oncology Letters, 21, 236. https://doi.org/10.3892/ol.2021.12497
MLA
Li, M., Liao, X., Li, C., Wang, T., Sun, Y., Yang, K., Jiang, P., Shi, S., Zhang, W., Zhang, K., Li, C., Yang, P."Lycorine hydrochloride induces reactive oxygen species‑mediated apoptosis via the mitochondrial apoptotic pathway and the JNK signaling pathway in the oral squamous cell carcinoma HSC‑3 cell line". Oncology Letters 21.3 (2021): 236.
Chicago
Li, M., Liao, X., Li, C., Wang, T., Sun, Y., Yang, K., Jiang, P., Shi, S., Zhang, W., Zhang, K., Li, C., Yang, P."Lycorine hydrochloride induces reactive oxygen species‑mediated apoptosis via the mitochondrial apoptotic pathway and the JNK signaling pathway in the oral squamous cell carcinoma HSC‑3 cell line". Oncology Letters 21, no. 3 (2021): 236. https://doi.org/10.3892/ol.2021.12497
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