Upregulation of phosphatidylinositol glycan anchor biosynthesis class C is associated with unfavorable survival prognosis in patients with hepatocellular carcinoma

Peng,Xiulan; Lei,Changjiang; He,Anbing; Luo,Renfeng; Cai,Yahong; Dong,Weiguo

doi:10.3892/ol.2021.12498

Upregulation of phosphatidylinositol glycan anchor biosynthesis class C is associated with unfavorable survival prognosis in patients with hepatocellular carcinoma

Authors:
- Xiulan Peng
- Changjiang Lei
- Anbing He
- Renfeng Luo
- Yahong Cai
- Weiguo Dong
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Affiliations: Department of Oncology, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, P.R. China, Department of Surgery, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, P.R. China, Department of Diagnostics, Medical College, Jianghan University, Wuhan, Hubei 430075, P.R. China, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
Published online on: January 26, 2021 https://doi.org/10.3892/ol.2021.12498
Article Number: 237
Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumor, and is the second highest cause of cancer‑associated mortality, behind lung carcinoma. It is urgent to identify novel genes that can be used to confirm the diagnosis and prognosis of patients with HCC. The present study aimed to investigate the expression pattern of phosphatidylinositol glycan anchor biosynthesis class C (PIGC) in HCC and assess its clinical prognostic significance. Bioinformatics analyses were used to investigate PIGC mRNA expression levels in HCC and adjacent non‑cancerous tissue samples. Furthermore, the present study detected the expression levels of PIGC protein in HCC and matched normal tissue samples via immunohistochemistry, and evaluated the prognostic significance of PIGC protein in HCC. The levels of PIGC mRNA and protein were found to be significantly higher in tissue from patients with HCC compared with non‑cancerous liver tissue. The survival analysis showed that the expression levels of PIGC mRNA or protein were associated with the survival of patients with HCC. PIGC protein expression was significantly associated with Tumor‑Node‑Metastasis stage. A negative correlation between PIGC DNA methylation and mRNA expression was observed (Spearman r=‑0.453). PIGC is an oncogene that is negatively regulated by DNA methylation, and high levels of PIGC mRNA or protein may predict an unfavorable prognosis in patients with HCC.

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