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Review Open Access

Mesenchymal stem cell carriers enhance anti‑tumor efficacy of oncolytic virotherapy (Review)

  • Authors:
    • Xianyao Wang
    • Xing Zhao
    • Zhixu He
  • View Affiliations / Copyright

    Affiliations: Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guiyang, Guizhou 550004, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 238
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    Published online on: January 28, 2021
       https://doi.org/10.3892/ol.2021.12499
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Abstract

Oncolytic viruses (OVs) specifically infect, replicate and eventually destroy tumor cells, with no concomitant toxicity to adjacent normal cells. Furthermore, OVs can regulate tumor microenvironments and stimulate anti‑tumor immune responses. Mesenchymal stem cells (MSCs) have inherent tumor tropisms and immunosuppressive functions. MSCs carrying OVs not only protect viruses from clearing by the immune system, but they also deliver the virus to tumor lesions. Equally, cytokines released by MSCs enhance anti‑tumor immune responses, suggesting that MSCs carrying OVs may be considered as a promising strategy in enhancing the anti‑tumor efficacies of virotherapy. In the present review, preclinical and clinical studies were evaluated and discussed, as well as the effectiveness of MSCs carrying OVs for tumor treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Zhao X and He Z: Mesenchymal stem cell carriers enhance anti‑tumor efficacy of oncolytic virotherapy (Review). Oncol Lett 21: 238, 2021.
APA
Wang, X., Zhao, X., & He, Z. (2021). Mesenchymal stem cell carriers enhance anti‑tumor efficacy of oncolytic virotherapy (Review). Oncology Letters, 21, 238. https://doi.org/10.3892/ol.2021.12499
MLA
Wang, X., Zhao, X., He, Z."Mesenchymal stem cell carriers enhance anti‑tumor efficacy of oncolytic virotherapy (Review)". Oncology Letters 21.4 (2021): 238.
Chicago
Wang, X., Zhao, X., He, Z."Mesenchymal stem cell carriers enhance anti‑tumor efficacy of oncolytic virotherapy (Review)". Oncology Letters 21, no. 4 (2021): 238. https://doi.org/10.3892/ol.2021.12499
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Zhao X and He Z: Mesenchymal stem cell carriers enhance anti‑tumor efficacy of oncolytic virotherapy (Review). Oncol Lett 21: 238, 2021.
APA
Wang, X., Zhao, X., & He, Z. (2021). Mesenchymal stem cell carriers enhance anti‑tumor efficacy of oncolytic virotherapy (Review). Oncology Letters, 21, 238. https://doi.org/10.3892/ol.2021.12499
MLA
Wang, X., Zhao, X., He, Z."Mesenchymal stem cell carriers enhance anti‑tumor efficacy of oncolytic virotherapy (Review)". Oncology Letters 21.4 (2021): 238.
Chicago
Wang, X., Zhao, X., He, Z."Mesenchymal stem cell carriers enhance anti‑tumor efficacy of oncolytic virotherapy (Review)". Oncology Letters 21, no. 4 (2021): 238. https://doi.org/10.3892/ol.2021.12499
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