Open Access

Upregulated hsa_circ_0000129 expression promotes proliferation and migration of breast cancer cells

  • Authors:
    • Zhenghua Zhang
    • Zhan Shi
    • Su Zhang
    • Qiong Lu
    • Haimin Wei
    • Xueyong Wu
    • Li Han
  • View Affiliations

  • Published online on: January 28, 2021     https://doi.org/10.3892/ol.2021.12500
  • Article Number: 239
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) are considered potential biomarkers in the pathogenesis and detection of several types of cancer. The present study aimed to investigate the role of hsa_circ_0000129 in the pathogenesis and molecular mechanism underlying breast cancer. A total of 68 pairs of breast cancer and corresponding paracancerous tissue samples, three different breast cancer cell lines (MCF‑7, MDA‑MB‑231 and MDA‑MB‑468) and a normal human breast cell line (MCF‑10A) were used to investigate the expression of hsa_circ_0000129. The effect of hsa_circ_0000129 on cell proliferation, migration and colony formation was assessed in MCF‑7 and MDA‑MB‑468 cells, along with the expression of enhancer of zeste homolog 2 (EZH2). The results demonstrated that hsa_circ_0000129 expression was significantly higher in breast cancer tissues compared with normal tissues. In addition, high hsa_circ_0000129 expression was significantly associated with lymph node metastasis and a higher tumor‑node‑metastasis stage. Comparisons between the breast cancer cell lines (MCF‑7, MDA‑MB‑231 and MDA‑MB‑468) and MCF‑10A cells indicated similar results. MCF‑7 cells overexpressed with hsa_circ_0000129 significantly increased cell proliferation, migration and colony formation compared with the negative control group, the effects of which were reversed following hsa_circ_0000129 knockdown in MDA‑MB‑468 cells. Furthermore, EZH2 expression was positively associated with hsa_circ_0000129 expression. Taken together, the results of the present study suggest that hsa_circ_0000129 may represent a promising prognostic biomarker for breast cancer. In addition, the role of hsa_circ_0000129 in breast cancer cell lines indicates a mechanism for tumorigenesis, as well as a potent target for the treatment of malignant progression.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Z, Shi Z, Zhang S, Lu Q, Wei H, Wu X and Han L: Upregulated hsa_circ_0000129 expression promotes proliferation and migration of breast cancer cells. Oncol Lett 21: 239, 2021.
APA
Zhang, Z., Shi, Z., Zhang, S., Lu, Q., Wei, H., Wu, X., & Han, L. (2021). Upregulated hsa_circ_0000129 expression promotes proliferation and migration of breast cancer cells. Oncology Letters, 21, 239. https://doi.org/10.3892/ol.2021.12500
MLA
Zhang, Z., Shi, Z., Zhang, S., Lu, Q., Wei, H., Wu, X., Han, L."Upregulated hsa_circ_0000129 expression promotes proliferation and migration of breast cancer cells". Oncology Letters 21.4 (2021): 239.
Chicago
Zhang, Z., Shi, Z., Zhang, S., Lu, Q., Wei, H., Wu, X., Han, L."Upregulated hsa_circ_0000129 expression promotes proliferation and migration of breast cancer cells". Oncology Letters 21, no. 4 (2021): 239. https://doi.org/10.3892/ol.2021.12500