Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma

  • Authors:
    • Xing Zhong
    • Zhiliang Liu
    • Qingfeng Luo
    • Jingao Li
    • Weiwei Zhang
    • Yuerong Shuang
  • View Affiliations / Copyright

    Affiliations: Department of Lymphatic and Hematological Oncology, Jiangxi Cancer Hospital (Affiliated Cancer Hospital of Nanchang University), Nanchang, Jiangxi 330006, P.R. China, Department of Pathology, Jiangxi Cancer Hospital (Affiliated Cancer Hospital of Nanchang University), Nanchang, Jiangxi 330006, P.R. China, Department of Radiotherapy, Jiangxi Cancer Hospital (Affiliated Cancer Hospital of Nanchang University), Nanchang, Jiangxi 330006, P.R. China, Academic Department, Jiangxi Health Vocational College, Nanchang, Jiangxi 330029, P.R. China
    Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 245
    |
    Published online on: February 2, 2021
       https://doi.org/10.3892/ol.2021.12506
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Diffuse large B‑cell lymphoma (DLBCL) is the most common and heterogeneous lymphoid malignancy. The subtype with MYC and BCL‑2 double‑expressor lymphoma (DEL) was defined by its aggressive nature and poor survival outcome. Therefore, the development of effective therapies for the DEL subtype is imperative. Fatty acid synthase (FASN) activity is associated with altered lipid metabolism and aberrant protein translation in DLBCL. However, the inter‑regulation of these key processes is not fully determined in DEL. In the present study, the clinical and biological impact of FASN was investigated in the DEL subtype. Initially, FASN expression levels were analyzed from a patient cohort and the data indicated that the highest FASN expression was noted in DEL tissues compared with that noted in the DLBCL and reactive lymphoid hyperplasia tissues. Patients with DEL with combined high‑FASN expression indicated poorer EFS outcomes than the rest of the patients. In vitro data indicated that FASN was overexpressed in SU‑DHL‑2 and U2932 cells. Silencing FASN decreased cell growth and promoted cell apoptosis by modulating the pERK/BCL‑2 signaling pathway. In conclusion, the present study indicated that FASN was overexpressed in DEL and that its expression was associated with poor survival outcomes. Furthermore, the data demonstrated that FASN regulated the biological function via the pERK/BCL‑2 signaling pathway. FASN serves a critical role in the progression of DEL and its expression may be associated with the development to a more aggressive phenotype of DLBCL. Therefore, it may be considered a potential therapeutic target for DLBCL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Cazzola M: Introduction to a review series: The 2016 revision of the WHO classification of tumors of hematopoietic and lymphoid tissues. Blood. 127:2361–2364. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Lagunas-Rangel FA: A new history: The 2016 revision of the WHO classification of tumors of hematopoietic and lymphoid tissues. Austin Leuk. 1:10012016.

3 

Lukenbill J and Hill B: Relapsed/Refractory diffuse large B-cell lymphoma: Review of the management of transplant-eligible patients. Leuk Lymphoma. 56:293–300. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Jain P, Fayad LE, Rosenwald A, Young KH and O'Brien S: Recent advances in de novo CD5+ diffuse large B cell lymphoma. Am J Hematol. 88:798–802. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Reagan PM and Davies A: Current treatment of double hit and double expressor lymphoma. Hematology Am Soc Hematol Educ Program. 2017:295–297. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Saumyaranjan M, Arun P, Moien L, Ansh G, Parashant R, Minakshi S, Ajay G, Ranjit S and Atul S: Clinicopathological profile of primary double expressor lymphoma. Clin Lymphoma Myeloma Leuk. 19 (Suppl 1):S2572019. View Article : Google Scholar

7 

Choe JY, Park M, Yun JY, Na HY, Go H, Kim HJ, Oh S and Kim JE: PELI1 expression is correlated with MYC and BCL6 expression and associated with poor prognosis in diffuse large B-cell lymphoma. Mod Pathol. 29:1313–1323. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Smith SM: Aggressive B-cell lymphoma: The double-hit and double-expressor phenotypes. Clin Adv Hematol Oncol. 15:40–42. 2017.PubMed/NCBI

9 

Danilova OV, Dumont LJ, Levy NB, Lansigan F, Kinlaw WB, Danilov AV and Kaur P: FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma. J Hematop. 6:11–18. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Menendez JA and Lupu R: Fatty acid synthase (FASN) as a therapeutic target in breast cancer. Expert OpinTher Targets. 21:1001–1016. 2017. View Article : Google Scholar

11 

Wang H, Xi Q and Wu G: Fatty acid synthase regulates invasion and metastasis of colorectal cancer via wnt signaling pathway. Cancer Med. 5:1599–1606. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Menendez JA and Lupu R: Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer. 7:763–777. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Liu ZL, Wang G, Peng AF, Luo QF, Zhou Y and Huang SH: Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis. Oncol Lett. 4:878–882. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Sun TH, Zhong X, Song HH, Liu JM, Li JG, Leung F, Lu WW and Liu ZL: Anoikis resistant mediated by FASN promoted growth and metastasis of osteosarcoma. Cell Death Dis. 10:2982019. View Article : Google Scholar : PubMed/NCBI

15 

Hu N, Li Y, Zhao Y, Wang Q, You Jc, Zhang Xd and Ye Lh: A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. Acta Pharmacol Sin. 32:921–929. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Bian Y, Yu Y, Wang S and Li L: Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer. Biochem Biophys Res Commun. 463:612–617. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Akiyama T, Choong PF and Dass CR: RANK-Fc inhibits malignancy via inhibiting ERK activation and evoking caspase-3-mediated anoikis in human osteosarcoma cells. Clin Exp Metastasis. 27:207–215. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Kapadia B, Nanaji NM, Bhalla K, Bhandary B, Lapidus R, Beheshti A, Evens AM and Gartenhaus RB: Fatty acid synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL. Nat Commun. 9:8292018. View Article : Google Scholar : PubMed/NCBI

19 

Uddin S, Hussain AR, Ahmed M, Bu R, Ahmed SO, Ajarim D, Al-Dayel F, Bavi P and Al-Kuraya KS: Inhibition of fatty acid synthase suppresses c-met receptor kinase and induces apoptosis in diffuse large B-cell lymphoma. Mol Cancer Ther. 9:1244–1255. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Gonzalez-Guerrico A and Lupu R: Fatty acid synthase (FASN) as a therapeutic target for breast cancer metastasis. Cancer Res. 69 (Suppl 24):61602009.

21 

Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E and Lister TA: Recommendations for initial evaluation, staging, and response assessment of hodgkin and non-hodgkin lymphoma: The lugano classification. J Clin Oncol. 32:3059–3068. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Müller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, et al: Conformation of molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 103:275–282. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Johnson NA, Slack GW, Savage KJ, Connors JM, Ben-Neriah S, Rogic S, Scott DW, Tan KL, Steidl C, Sehn LH, et al: Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol. 30:3452–3459. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Bogusz AM, Kovach AE, Le LP, Feng D, Baxter RH and Sohani AR: Diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression shows evidence of active B-cell receptor signaling by quantitative immunofluorescence. PLoS One. 12:e01723642017. View Article : Google Scholar : PubMed/NCBI

25 

Giró-Perafita A, Sarrats A, Pérez-Bueno F, Oliveras G, Buxó M, Brunet J, Viñas G and Miquel TP: Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer. Oncotarget. 8:74391–74405. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Puig T, Blancafort A, Casoliva G, Oliveras G, Casas M, Buxo M, Saiz E, Viñas G, Dorca J and Porta R: Prospective analysis of fatty acid synthase (FASN) in breast cancer tissue of early-stage breast cancer patients. Cancer Res. 72 (24 Suppl):P4-09-10. 2012.PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta DeltaC(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Yao S, Xu F, Chen Y, Ge Y, Zhang F, Huang H, Li L, Lin D, Luo X, Xu J, et al: Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation. J Exp Clin Cancer Res. 36:102017. View Article : Google Scholar : PubMed/NCBI

29 

Tarantelli C, Gaudio E, Kwee I, Cascione L, Bernasconi E, Hillmann P, Stathis A, Stussi G, Fabbro D, Wicki A, et al: The dual PI3K/mTOR inhibitor PQR309 has synergistic activity with other targeted agents in diffuse large B cell lymphomas. Blood. 126:40052015. View Article : Google Scholar

30 

Takahashi H, Miura K, Nakagawa M, Sugitani M, Amano Y, Kurita D, Sakagami M, Ohtake S, Uchino Y, Kodaira H, et al: Negative impact of concurrent overexpression of MYC and BCL2 in patients with advanced diffuse large B-cell lymphoma treated with dose-intensified immunochemotherapy. Leuk Lymphoma. 57:2784–2790. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Li L, Zhang X, Zhang T, Song Z, Hu G, Li W, Li L, Qiu L, Qian Z, Zhou S, et al: Prognostic significance of BCL-2 and BCL-6 expression in MYC-positive DLBCL. Clin Lymphoma Myeloma Leuk. 18:e381–e389. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Ma Z, Niu J, Cao Y, Pang X, Cui W, Zhang W and Li X: Clinical significance of ‘double-hit’ and ‘double-expression’ lymphomas. J Clin Pathol. 73:126–138. 2020. View Article : Google Scholar : PubMed/NCBI

33 

Johnston PB, LaPlant B, McPhail E, Habermann TM, Inwards DJ, Micallef IN, Colgan JP, Nowakowski GS, Ansell SM and Witzig TE: Everolimus combined with R-CHOP-21 for new, untreated, diffuse large B-cell lymphoma (NCCTG 1085 [Alliance]): Safety and efficacy results of a phase 1 and feasibility trial. Lancet Haematol. 3:e309–e316. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Chiappella A, Witzig TE, Vitolo U, Gascoyne R, Russo J, Amoroso B, Hudak K, Ogunkanmi A, Xu Y, Ruiz W, et al: ROBUST: Phase III randomized study of LENALIDOMIDE/R-CHOP VS PLACEBO/R-chop in untreated ABC-type diffuse large B-cell lymphoma and feasibility of cell of origin subtyping. Hematol Oncol. 35:419. 2017. View Article : Google Scholar

35 

Brower V: Ibrutinib promising in subtype of DLBCL. Lancet Oncol. 16:e4282015. View Article : Google Scholar : PubMed/NCBI

36 

Westin JR, Nastoupil L, Hagemeister F, Fayad L, Young K, McDonnell T, Chuang H, Ahmed S, Nair R, Steiner R, et al: SMART start: Rituximab, lenalidomide, and ibrutinib alone prior to combination with chemotherapy for patients with newly diagnosed diffuse large B-cell lymphoma. Hematol Oncol. 37:78–79. 2019. View Article : Google Scholar

37 

Gelebart P, Zak Z, Anand M, Belch A and Lai R: Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma. PLoS One. 7:e337382012. View Article : Google Scholar : PubMed/NCBI

38 

Kant S, Kumar A and Singh SM: Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: Implication in macrophage differentiation and activation. PLoS One. 8:e823962013. View Article : Google Scholar : PubMed/NCBI

39 

Long QQ, Yi Yx, Qiu J, Xu CJ and Huang PL: Fatty acid synthase (FASN) levels in serum of colorectal cancer patients: Correlation with clinical outcomes. Tumour Biol. 35:3855–3859. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Ezzeddini R, Taghikhani M, Somi MH, Samadi N and Rasaee MJ: Clinical importance of FASN in relation to HIF-1α and SREBP-1c in gastric adenocarcinoma. Life Sci. 224:169–176. 2019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhong X, Liu Z, Luo Q, Li J, Zhang W and Shuang Y: Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma. Oncol Lett 21: 245, 2021.
APA
Zhong, X., Liu, Z., Luo, Q., Li, J., Zhang, W., & Shuang, Y. (2021). Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma. Oncology Letters, 21, 245. https://doi.org/10.3892/ol.2021.12506
MLA
Zhong, X., Liu, Z., Luo, Q., Li, J., Zhang, W., Shuang, Y."Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma". Oncology Letters 21.4 (2021): 245.
Chicago
Zhong, X., Liu, Z., Luo, Q., Li, J., Zhang, W., Shuang, Y."Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma". Oncology Letters 21, no. 4 (2021): 245. https://doi.org/10.3892/ol.2021.12506
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong X, Liu Z, Luo Q, Li J, Zhang W and Shuang Y: Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma. Oncol Lett 21: 245, 2021.
APA
Zhong, X., Liu, Z., Luo, Q., Li, J., Zhang, W., & Shuang, Y. (2021). Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma. Oncology Letters, 21, 245. https://doi.org/10.3892/ol.2021.12506
MLA
Zhong, X., Liu, Z., Luo, Q., Li, J., Zhang, W., Shuang, Y."Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma". Oncology Letters 21.4 (2021): 245.
Chicago
Zhong, X., Liu, Z., Luo, Q., Li, J., Zhang, W., Shuang, Y."Upregulation of fatty acid synthase in MYC and BCL‑2 double‑expressor lymphoma". Oncology Letters 21, no. 4 (2021): 245. https://doi.org/10.3892/ol.2021.12506
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team