Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review

  • Authors:
    • Andreas Larentzakis
    • Evangelos Anagnostou
    • Konstantinos Georgiou
    • Gavriella-Zoi Vrakopoulou
    • Constantinos G. Zografos
    • Georgios C. Zografos
    • Konstantinos G. Toutouzas
  • View Affiliations / Copyright

    Affiliations: First Department of Propaedeutic Surgery, Athens Medical School, National and Kapodistrian University of Athens, Hippocration General Athens Hospital, Athens 11527, Greece, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, E1 2AT London, UK, First Department of Surgery, Athens Medical School, National and Kapodistrian University of Athens, Laikon General Hospital, Goudi, Athens 11527, Greece
    Copyright: © Larentzakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 246
    |
    Published online on: February 3, 2021
       https://doi.org/10.3892/ol.2021.12507
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pancreatic adenocarcinoma is one of the deadliest types of cancer worldwide, with a 5‑year survival rate of 8% despite recent treatment advancements. The present systematic review aimed to investigate the role of hyperthermic intraperitoneal chemotherapy (HIPEC) following surgical resection for pancreatic adenocarcinoma, with or without peritoneal carcinomatosis. A systematic search of the MEDLINE and SCOPUS electronic databases was performed according to PRISMA guidelines. All possible relevant articles published between January 1980 and May 2019 were retrieved using multiple search terms associated with HIPEC and pancreatic adenocarcinoma. The initial search resulted in 1,244 reports, which condensed to 41 reports following screening of titles and abstracts, and subsequently to four reports following full‑text thorough examination. The four reports included involved a prospective cohort study of HIPEC use in resectable pancreatic adenocarcinoma, and three retrospective studies of HIPEC use following cytoreductive surgery for peritoneal carcinomatosis due to pancreatic adenocarcinoma, resulting in a total of 47 patients. The overall survival ranged between 2 and 62 months, and the hospital mortality rate was 8.5%. Morbidity (34%) was mainly attributed to anastomotic leak or respiratory failure. Due to the small sample size and low quality of evidence of the included studies, no valid conclusions could be drawn. Therefore, further studies are required to justify the use of HIPEC as an adjuvant therapy in resectable pancreatic adenocarcinoma, while cytoreductive surgery and HIPEC in peritoneal carcinomatosis of pancreatic origin seems not only not useful but also unsafe at this level of evidence.
View Figures

Figure 1

View References

1 

Baxter NN, Whitson BA and Tuttle TM: Trends in the treatment and outcome of pancreatic cancer in the United States. Ann Surg Oncol. 14:1320–1326. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Beger HG, Rau B, Gansauge F, Leder G, Schwarz M and Poch B: Pancreatic Cancer - Low Survival Rates. Dtsch Arztebl Int. 105:255–262. 2008.PubMed/NCBI

3 

Ducreux M, Cuhna AS, Caramella C, Hollebecque A, Burtin P, Goéré D, Seufferlein T, Haustermans K, Van Laethem JL, Conroy T, et al ESMO Guidelines Committee, : Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 26 (Suppl 5):v56–v68. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Schneider G, Siveke JT, Eckel F and Schmid RM: Pancreatic cancer: Basic and clinical aspects. Gastroenterology. 128:1606–1625. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Sirri E, Castro FA, Kieschke J, Jansen L, Emrich K, Gondos A, Holleczek B, Katalinic A, Urbschat I, Vohmann C, et al: Recent Trends in Survival of Patients With Pancreatic Cancer in Germany and the United States. Pancreas. 45:908–914. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Minicozzi P, Cassetti T, Vener C and Sant M: Analysis of incidence, mortality and survival for pancreatic and biliary tract cancers across Europe, with assessment of influence of revised European age standardisation on estimates. Cancer Epidemiol. 55:52–60. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Cleary SP, Gryfe R, Guindi M, Greig P, Smith L, Mackenzie R, Strasberg S, Hanna S, Taylor B, Langer B, et al: Prognostic factors in resected pancreatic adenocarcinoma: Analysis of actual 5-year survivors. J Am Coll Surg. 198:722–731. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Khorana AA, Mangu PB, Berlin J, Engebretson A, Hong TS, Maitra A, Mohile SG, Mumber M, Schulick R, Shapiro M, et al: Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 34:2541–2556. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Bramhall SR, Allum WH, Jones AG, Allwood A, Cummins C and Neoptolemos JP: Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study. Br J Surg. 82:111–115. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Lim JE, Chien MW and Earle CC: Prognostic factors following curative resection for pancreatic adenocarcinoma: A population-based, linked database analysis of 396 patients. Ann Surg. 237:74–85. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Raut CP, Tseng JF, Sun CC, Wang H, Wolff RA, Crane CH, Hwang R, Vauthey JN, Abdalla EK, Lee JE, et al: Impact of resection status on pattern of failure and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Ann Surg. 246:52–60. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Rossi ML, Rehman AA and Gondi CS: Therapeutic options for the management of pancreatic cancer. World J Gastroenterol. 20:11142–11159. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Müller PC, Frey MC, Ruzza CM, Nickel F, Jost C, Gwerder C, Hackert T, Z'graggen K and Kessler U: Neoadjuvant Chemotherapy in Pancreatic Cancer: An Appraisal of the Current High-Level Evidence. Pharmacology. 1–11. 2020.doi: 10.1159/000510343. View Article : Google Scholar

15 

Ren B, Cui M, Yang G, Wang H, Feng M, You L and Zhao Y: Tumor microenvironment participates in metastasis of pancreatic cancer. Mol Cancer. 17:1082018. View Article : Google Scholar : PubMed/NCBI

16 

Spratt JS, Edwards M, Kubota T, Lindberg R and Tseng MT: Peritoneal carcinomatosis: Anatomy, physiology, diagnosis, management. Curr Probl Cancer. 10:553–584. 1986. View Article : Google Scholar

17 

Sugarbaker PH: Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology. Principles of Management. Cancer Treatment and Research. 82. Springer; Boston, MA: pp. 79–100. 1996, View Article : Google Scholar

18 

del Castillo CF and Warshaw L: Peritoneal metastases in pancreatic carcinoma. Hepatogastroenterology. 40:430–432. 1993.PubMed/NCBI

19 

Yachida S and Iacobuzio-Donahue CA: The pathology and genetics of metastatic pancreatic cancer. Arch Pathol Lab Med. 133:413–422. 2009.PubMed/NCBI

20 

Hishinuma S, Ogata Y, Matsui J and Ozawa I: Results of surgery and adjuvant radiotherapy for pancreatic cancer. J Hepatobiliary Pancreat Surg. 5:143–150. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Sugarbaker P: An overview of peritonectomy, visceral resections, and perioperative chemotherapy for peritoneal surface malignancy. Cytoreductive Surgery and Perioperative Chemotherapy for Peritoneal Surface Malignancy. Ciné-Med, Inc.; Woodbury, CT, USA: pp. 1–30. 2012

22 

Chua TC, Moran BJ, Sugarbaker PH, Levine EA, Glehen O, Gilly FN, Baratti D, Deraco M, Elias D, Sardi A, et al: Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol. 30:2449–2456. 2012. View Article : Google Scholar : PubMed/NCBI

23 

van Driel WJ, Koole SN, Sikorska K, Schagen van Leeuwen JH, Schreuder HWR, Hermans RHM, de Hingh IHJT, van der Velden J, Arts HJ, Massuger LFAG, et al: Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer. N Engl J Med. 378:230–240. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Yan TD, Deraco M, Baratti D, Kusamura S, Elias D, Glehen O, Gilly FN, Levine EA, Shen P, Mohamed F, et al: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: Multi-institutional experience. J Clin Oncol. 27:6237–6242. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Sugarbaker PH: New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome? Lancet Oncol. 7:69–76. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Elias D, Blot F, El Otmany A, Antoun S, Lasser P, Boige V, Rougier P and Ducreux M: Curative treatment of peritoneal carcinomatosis arising from colorectal cancer by complete resection and intraperitoneal chemotherapy. Cancer. 92:71–76. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Verwaal VJ, Bruin S, Boot H, van Slooten G and van Tinteren H: 8-year follow-up of randomized trial: Cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer. Ann Surg Oncol. 15:2426–2432. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H and Zoetmulder FA: Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol. 21:3737–3743. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Beeharry MK, Zhu Z-L, Liu W-T, Yao X–X, Yan M and Zhu Z-G: Prophylactic HIPEC with radical D2 gastrectomy improves survival and peritoneal recurrence rates for locally advanced gastric cancer: Personal experience from a randomized case control study. BMC Cancer. 19:932. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Yang X-J, Huang C-Q, Suo T, Mei LJ, Yang GL, Cheng FL, Zhou YF, Xiong B, Yonemura Y and Li Y: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: Final results of a phase III randomized clinical trial. Ann Surg Oncol. 18:1575–1581. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J and Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 6:e10001002009. View Article : Google Scholar : PubMed/NCBI

32 

Moher D, Liberati A, Tetzlaff J and Altman DG: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 339:b25352009. View Article : Google Scholar : PubMed/NCBI

33 

Higgins JP, Altman DG and Sterne JA: Assessing risk of bias in included studies. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Higgins JP and Green S; The Cochrane Collaboration, : https://handbook-5-1.cochrane.orgOctober 17–2019 View Article : Google Scholar

34 

Tentes A-A, Stamou K, Pallas N, Karamveri C, Kyziridis D and Hristakis C: The effect of hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) as an adjuvant in patients with resectable pancreatic cancer. Int J Hyperthermia. 32:895–899. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Tentes A-A, Pallas N, Karamveri C, Kyziridis D and Hristakis C: Cytoreduction and HIPEC for peritoneal carcinomatosis of pancreatic cancer. J BUON. 23:482–487. 2018.PubMed/NCBI

36 

Farma JM, Pingpank JF, Libutti SK, Bartlett DL, Ohl S, Beresneva T and Alexander HR: Limited survival in patients with carcinomatosis from foregut malignancies after cytoreduction and continuous hyperthermic peritoneal perfusion. J Gastrointest Surg. 9:1346–1353. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Fujimura T, Yonemura Y, Fujita H, Michiwa Y, Kawamura T, Nojima N, Sato T, Fushida S, Nishimura G, Miwa K, et al: Chemohyperthermic peritoneal perfusion for peritoneal dissemination in various intra-abdominal malignancies. Int Surg. 84:60–66. 1999.PubMed/NCBI

38 

Thomassen I, Lemmens VE, Nienhuijs SW, Luyer MD, Klaver YL and de Hingh IH: Incidence, prognosis, and possible treatment strategies of peritoneal carcinomatosis of pancreatic origin: A population-based study. Pancreas. 42:72–75. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Conlon KC, Dougherty E, Klimstra DS, Coit DG, Turnbull AD and Brennan MF: The value of minimal access surgery in the staging of patients with potentially resectable peripancreatic malignancy. Ann Surg. 223:134–140. 1996. View Article : Google Scholar : PubMed/NCBI

40 

Merchant NB and Conlon KC: Laparoscopic evaluation in pancreatic cancer. Semin Surg Oncol. 15:155–165. 1998. View Article : Google Scholar : PubMed/NCBI

41 

Vargas R, Nino-Murcia M, Trueblood W and Jeffrey RB Jr: MDCT in Pancreatic adenocarcinoma: Prediction of vascular invasion and resectability using a multiphasic technique with curved planar reformations. AJR Am J Roentgenol. 182:419–425. 2004. View Article : Google Scholar : PubMed/NCBI

42 

González-Moreno S, González-Bayón LA and Ortega-Pérez G: Hyperthermic intraperitoneal chemotherapy: Rationale and technique. World J Gastrointest Oncol. 2:68–75. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Harmon RL and Sugarbaker PH: Prognostic indicators in peritoneal carcinomatosis from gastrointestinal cancer. Int Semin Surg Oncol. 2:32005. View Article : Google Scholar : PubMed/NCBI

44 

Portilla AG, Sugarbaker PH and Chang D: Second-look surgery after cytoreduction and intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal cancer: Analysis of prognostic features. World J Surg. 23:23–29. 1999. View Article : Google Scholar : PubMed/NCBI

45 

Sugarbaker PH and Chang D: Results of treatment of 385 patients with peritoneal surface spread of appendiceal malignancy. Ann Surg Oncol. 6:727–731. 1999. View Article : Google Scholar : PubMed/NCBI

46 

HIPEC as Neoadjuvant Treatment for Resectable Pancreatic Adenocarcinoma. NCT02850874. Clinicaltrials.govJuly 28–2019

47 

Intrabdominal Hyperthermic Chemotherapy and Pancreatic Cancer. NCT03251365. Clinicaltrials.govJuly 28–2019

48 

Péron J, Giai J, Maucort-Boulch D and Buyse M: The Benefit-Risk Balance of Nab-Paclitaxel in Metastatic Pancreatic Adenocarcinoma. Pancreas. 48:275–280. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Klaver CEL, Wisselink DD, Punt CJA, Snaebjornsson P, Crezee J, Aalbers AGJ, Brandt A, Bremers AJA, Burger JWA, Fabry HFJ, et al COLOPEC collaborators group, : Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): A multicentre, open-label, randomised trial. Lancet Gastroenterol Hepatol. 4:761–770. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Quenet F, Elias D, Roca L, Goere D, Ghouti L, Pocard M, Facy O, Arvieux C, Lorimier G, Pezet D, et al: A UNICANCER phase III trial of hyperthermic intra-peritoneal chemotherapy (HIPEC) for colorectal peritoneal carcinomatosis (PC): PRODIGE 7. J Clin Oncol. 36 (Suppl. 18):LBA3503. 2018. View Article : Google Scholar

51 

Goéré D, Glehen O, Quenet F, Guilloit JM, Bereder JM, Lorimier G, Thibaudeau E, Ghouti L, Pinto A, Tuech JJ, et al BIG-RENAPE group, : Second-look surgery plus hyperthermic intraperitoneal chemotherapy versus surveillance in patients at high risk of developing colorectal peritoneal metastases (PROPHYLOCHIP-PRODIGE 15): A randomised, phase 3 study. Lancet Oncol. 21:1147–1154. 2020. View Article : Google Scholar : PubMed/NCBI

52 

Koh CE, Ansari N, Morris D and Moran B; Australian and New Zealand Peritoneal Malignancy Collaborative (ANZ PMC), : Beware mis-representation of PRODIGE 7: Danger of throwing out the cytoreductive surgery baby with the hyperthermic intraperitoneal chemotherapy bathwater. ANZ J Surg. 89:992–994. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Nagourney RA, Evans S, Tran PH, Nagourney AJ and Sugarbaker PH: Colorectal cancer cells from patients treated with FOLFOX or CAPOX are resistant to oxaliplatin. Eur J Surg Oncol. S0748-7983(20)30789-7. 2020.doi: 10.1016/j.ejso.2020.09.017. View Article : Google Scholar : PubMed/NCBI

54 

Lei ZY, Guan TP, Luo JL, Tang HS and Cui SZ: Rationality of performing hyperthermic intraperitoneal chemotherapy 5–8 weeks after primary tumor resection for patients with locally advanced colorectal cancer-based on COLOPEC. Zhonghua Wei Chang Wai Ke Za Zhi. 22:1115–1117. 2019.(In Chinese). PubMed/NCBI

55 

Segura-Sampedro JJ and Morales-Soriano R: Prophylactic HIPEC with oxaliplatin might be of benefit in T4 and perforated colon cancer: Another possible interpretation of the COLOPEC results. Rev Esp Enferm Dig. 112:6662020. View Article : Google Scholar : PubMed/NCBI

56 

Lim MC, Chang S-J, Yoo HJ, Nam B-H, Bristow R and Park S-Y: Randomized trial of hyperthermic intraperitoneal chemotherapy (HIPEC) in women with primary advanced peritoneal, ovarian, and tubal cancer. J Clin Oncol. 35 (Suppl 15):5520. 2017. View Article : Google Scholar

57 

de Bree E and Michelakis D: An overview and update of hyperthermic intraperitoneal chemotherapy in ovarian cancer. Expert Opin Pharmacother. 21:1479–1492. 2020. View Article : Google Scholar : PubMed/NCBI

58 

Fotopoulou C, Sehouli J, Mahner S, Harter P, Van Nieuwenhuysen E, Gonzalez-Martin A, Vergote I, Chiva L and Du Bois A: HIPEC: HOPE or HYPE in the fight against advanced ovarian cancer? Ann Oncol. 29:1610–1613. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Larentzakis A, Anagnostou E, Georgiou K, Vrakopoulou G, Zografos CG, Zografos GC and Toutouzas KG: Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review. Oncol Lett 21: 246, 2021.
APA
Larentzakis, A., Anagnostou, E., Georgiou, K., Vrakopoulou, G., Zografos, C.G., Zografos, G.C., & Toutouzas, K.G. (2021). Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review. Oncology Letters, 21, 246. https://doi.org/10.3892/ol.2021.12507
MLA
Larentzakis, A., Anagnostou, E., Georgiou, K., Vrakopoulou, G., Zografos, C. G., Zografos, G. C., Toutouzas, K. G."Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review". Oncology Letters 21.4 (2021): 246.
Chicago
Larentzakis, A., Anagnostou, E., Georgiou, K., Vrakopoulou, G., Zografos, C. G., Zografos, G. C., Toutouzas, K. G."Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review". Oncology Letters 21, no. 4 (2021): 246. https://doi.org/10.3892/ol.2021.12507
Copy and paste a formatted citation
x
Spandidos Publications style
Larentzakis A, Anagnostou E, Georgiou K, Vrakopoulou G, Zografos CG, Zografos GC and Toutouzas KG: Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review. Oncol Lett 21: 246, 2021.
APA
Larentzakis, A., Anagnostou, E., Georgiou, K., Vrakopoulou, G., Zografos, C.G., Zografos, G.C., & Toutouzas, K.G. (2021). Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review. Oncology Letters, 21, 246. https://doi.org/10.3892/ol.2021.12507
MLA
Larentzakis, A., Anagnostou, E., Georgiou, K., Vrakopoulou, G., Zografos, C. G., Zografos, G. C., Toutouzas, K. G."Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review". Oncology Letters 21.4 (2021): 246.
Chicago
Larentzakis, A., Anagnostou, E., Georgiou, K., Vrakopoulou, G., Zografos, C. G., Zografos, G. C., Toutouzas, K. G."Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review". Oncology Letters 21, no. 4 (2021): 246. https://doi.org/10.3892/ol.2021.12507
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team