Open Access

Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review

  • Authors:
    • Andreas Larentzakis
    • Evangelos Anagnostou
    • Konstantinos Georgiou
    • Gavriella-Zoi Vrakopoulou
    • Constantinos G. Zografos
    • Georgios C. Zografos
    • Konstantinos G. Toutouzas
  • View Affiliations

  • Published online on: February 3, 2021     https://doi.org/10.3892/ol.2021.12507
  • Article Number: 246
  • Copyright: © Larentzakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic adenocarcinoma is one of the deadliest types of cancer worldwide, with a 5‑year survival rate of 8% despite recent treatment advancements. The present systematic review aimed to investigate the role of hyperthermic intraperitoneal chemotherapy (HIPEC) following surgical resection for pancreatic adenocarcinoma, with or without peritoneal carcinomatosis. A systematic search of the MEDLINE and SCOPUS electronic databases was performed according to PRISMA guidelines. All possible relevant articles published between January 1980 and May 2019 were retrieved using multiple search terms associated with HIPEC and pancreatic adenocarcinoma. The initial search resulted in 1,244 reports, which condensed to 41 reports following screening of titles and abstracts, and subsequently to four reports following full‑text thorough examination. The four reports included involved a prospective cohort study of HIPEC use in resectable pancreatic adenocarcinoma, and three retrospective studies of HIPEC use following cytoreductive surgery for peritoneal carcinomatosis due to pancreatic adenocarcinoma, resulting in a total of 47 patients. The overall survival ranged between 2 and 62 months, and the hospital mortality rate was 8.5%. Morbidity (34%) was mainly attributed to anastomotic leak or respiratory failure. Due to the small sample size and low quality of evidence of the included studies, no valid conclusions could be drawn. Therefore, further studies are required to justify the use of HIPEC as an adjuvant therapy in resectable pancreatic adenocarcinoma, while cytoreductive surgery and HIPEC in peritoneal carcinomatosis of pancreatic origin seems not only not useful but also unsafe at this level of evidence.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Larentzakis A, Anagnostou E, Georgiou K, Vrakopoulou G, Zografos CG, Zografos GC and Toutouzas KG: Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review. Oncol Lett 21: 246, 2021
APA
Larentzakis, A., Anagnostou, E., Georgiou, K., Vrakopoulou, G., Zografos, C.G., Zografos, G.C., & Toutouzas, K.G. (2021). Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review. Oncology Letters, 21, 246. https://doi.org/10.3892/ol.2021.12507
MLA
Larentzakis, A., Anagnostou, E., Georgiou, K., Vrakopoulou, G., Zografos, C. G., Zografos, G. C., Toutouzas, K. G."Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review". Oncology Letters 21.4 (2021): 246.
Chicago
Larentzakis, A., Anagnostou, E., Georgiou, K., Vrakopoulou, G., Zografos, C. G., Zografos, G. C., Toutouzas, K. G."Place of hyperthermic intraperitoneal chemotherapy in the armament against pancreatic adenocarcinoma: A survival, mortality and morbidity systematic review". Oncology Letters 21, no. 4 (2021): 246. https://doi.org/10.3892/ol.2021.12507