Open Access

Interleukin‑18 and ‑10 may be associated with lymph node metastasis in breast cancer

  • Authors:
    • Teng Ma
    • Meng Kong
  • View Affiliations

  • Published online on: February 3, 2021     https://doi.org/10.3892/ol.2021.12515
  • Article Number: 253
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Reports on the expression of interleukin (IL)‑10 in breast cancer are rare. The present study investigated the correlation between IL‑18 and ‑10 in breast cancer, and assessed their clinical significance. Breast cancer (n=104) and breast fibroadenoma (n=31) tissues that were surgically removed and pathologically confirmed at Jinan Central Hospital Affiliated to Shandong University (Jinan, China) between November 2016 and January 2019 were collected. The expression of IL‑18 and ‑10 was observed via immunohistochemistry. Breast cancer tissues were positive for IL‑18 expression, which was primarily located in the cell membrane and cytoplasm. A significant difference in IL‑18 expression was observed between breast cancer and fibroadenoma tissues (75.0 vs. 19.4%; P<0.001). IL‑10 was expressed in breast cancer tissues and primarily located in the cytoplasm. Breast cancer tissues showed a significantly higher level of IL‑10 expression compared with breast fibroadenoma tissues (78.8 vs. 22.6%; P<0.001). The regions of positive IL‑18 and ‑10 expression were consistent. Tissues with positive expression of IL‑18 and/or ‑10 had a significantly higher rate of lymph node metastasis than those with negative expression (IL‑18: 67.9 vs. 42.3%; P=0.035; and IL‑10: 67.1 vs. 40.9%; P=0.047). In conclusion, IL‑18 is highly expressed in breast cancer and correlates positively with IL‑10. Both IL‑18 and ‑10 may correlate positively with lymph node metastasis in breast cancer.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-1074
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Spandidos Publications style
Ma T and Kong M: Interleukin‑18 and ‑10 may be associated with lymph node metastasis in breast cancer. Oncol Lett 21: 253, 2021.
APA
Ma, T., & Kong, M. (2021). Interleukin‑18 and ‑10 may be associated with lymph node metastasis in breast cancer. Oncology Letters, 21, 253. https://doi.org/10.3892/ol.2021.12515
MLA
Ma, T., Kong, M."Interleukin‑18 and ‑10 may be associated with lymph node metastasis in breast cancer". Oncology Letters 21.4 (2021): 253.
Chicago
Ma, T., Kong, M."Interleukin‑18 and ‑10 may be associated with lymph node metastasis in breast cancer". Oncology Letters 21, no. 4 (2021): 253. https://doi.org/10.3892/ol.2021.12515